Dehydroepiandrosterone inhibits ADAMTS expression via an ERK-dependent mechanism in chondrocytes.

Osteoarthritis (OA) is a joint disease in which cartilage degradation is the hallmark pathological change. In this study, we investigated the anti-osteoarthritic effects of DHEA in rabbit chondrocytes. Polymerase chain reaction was performed to evaluate the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, ADAMTS-5, aggrecan and collagen type 2.

The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations - A narrative review.

This comprehensive review examines the relationship between osteoarthritis (OA) and osteoporosis (OP), two common disorders in the elderly. OA involves joint cartilage degeneration and pain, while OP leads to fractures due to reduced bone mass. Despite different pathologies, both conditions share risk factors such as age and genetics.

[Experimental study on the regulation of subchondral bone plate osteoprotegerin/receptor activator of nuclear factor kappa-B ligand system by berberine to retard the development of osteoarthritis in rabbits].

Objective: To investigate the effect of intra-articular berberine injection on the structural remodeling of subchondral bone plate and osteoprotegerin/receptor activator of nuclear factor kappa-B ligand(OPG/RANKL) system expression in rabbits with osteoarthritis(OA).

Methods: Forty 12-month-old male rabbits with an average of(2.73±0.

Dehydroepiandrosterone and age-related musculoskeletal diseases: Connections and therapeutic implications.

Musculoskeletal disorders related to ageing are one of the most common causes of mortality and morbidity among elderly individuals worldwide. The typical constitutive components of the musculoskeletal system, including bone, muscle, and joints, gradually undergo a process of tissue loss and degeneration as a result of life-long mechanical and biological stress, ultimately leading to the onset of a series of age-related musculoskeletal diseases, including osteoporosis (OP), sarcopenia, and osteoarthritis (OA). Dehydroepiandrosterone (DHEA), a precursor of androgen secreted mainly by the adrenal gland, has attracted much attention as a marker for senescence due to its unique age-related changes.

Comparison between two rabbit models of posttraumatic osteoarthritis: A longitudinal tear in the medial meniscus and anterior cruciate ligament transection.

Animal osteoarthritis (OA) models have been developed to understand OA progression and evaluate new OA therapies. However, individual variations in joint lesions remain a critical problem in most current OA models. We established a novel rabbit model by creating a longitudinal tear in the medial meniscus body that was reproducible and similar to posttraumatic biomechanical disturbances in human OA.

Effect of sintering temperature on mineral composition and heavy metals mobility in tailings bricks.

In this study, the mixing mechanism and phase transition process of different metals during the sintering of tailings bricks with four different metal oxides (CuO, PbO, ZnO, and CdO) at temperatures ranging from 700 to 1100 °C for 2 h were investigated. The properties of the sintered product was characterized and analyzed, and the results showed that the main crystalline phases are quartz, cristobalite, hematite, and mullite while the metal oxides are ascribed to copper ferrite spinel (CuFeO), gahnite (ZnAlO), zinc ferrite spinel (ZnFeO), lead feldspar (PbAlSiO), and cadmium feldspar (CdAlSiO). Further analysis indicates that the heavy metals were transited into spinel or silicate structures with favorable efficiency.

Potential of dehydroepiandrosterone in modulating osteoarthritis-related pain.

Osteoarthritis (OA) is the most common form of degenerative arthropathy, and the primary symptom is chronic joint pain. Dehydroepiandrosterone (DHEA) exerts a chondroprotective effect against OA and has been reported to have potent structure-modifying effects on osteoarthritic cartilage, thereby attenuating disease progression. However, the ability of DHEA to modulate OA-related pain has not yet been verified.

Toxicity evaluation of textile dyeing effluent and its possible relationship with chemical oxygen demand.

Textile dyeing wastewater was the focus of much research because of its adverse effect on aquatic biota. In the present research, textile dyeing influent and effluent samples were collected from four textile dyeing wastewater treatment plants (TDPs) in Guangdong province, China, and their conventional indicators and toxicity were examined to reveal relationships. The relationship between toxicity and chemical oxygen demand (COD) was clearly established at individual TDPs.

Elimination and ecotoxicity evaluation of phthalic acid esters from textile-dyeing wastewater.

Phthalic acid esters (PAEs), presented in fabrics, surfactants and detergents, were discharged into the ecosystem during textile-dyeing wastewater treatment and might have adverse effects on water ecosystems. In this study, comprehensive investigations of the content and component distributions of 12 PAEs across different units of four textile-dyeing wastewater plants were carried out in Guangdong Province, China. Ecotoxicity assessments were also conducted based on risk quotients (RQs).