Publications by authors named "Hailey Patel"
Article Synopsis
- In Lusaka, Zambia, researchers studied adults with chronic hepatitis B and some with HIV by using a technique called fine needle aspiration (FNA) to take samples from their livers.
- They enrolled over 117 people and safely performed 47 follow-up procedures, making sure the participants were okay with the process.
- By analyzing the samples, they discovered different types of immune cells, which could help them learn more about hepatitis B and how to treat it better in Africa.
Background & Aims: Chronic viral infections present serious public health challenges; however, direct-acting antivirals (DAAs) are now able to cure nearly all patients infected with hepatitis C virus (HCV), representing the only cure of a human chronic viral infection to date. DAAs provide a valuable opportunity to study immune pathways in the reversal of chronic immune failures in an in vivo human system.
Methods: To leverage this opportunity, we used plate-based single-cell RNA-seq to deeply profile myeloid cells from liver fine needle aspirates in patients with HCV before and after DAA treatment.