Publications by authors named "Hailey Lefkofsky"
Article Synopsis
- Pharmacogenomic testing is increasingly important for psychiatric care, but more research is needed to understand its practical benefits in real-world settings.
- A study involving 15,000 patients revealed that 65% had potentially actionable genetic traits related to drug metabolism, particularly for the genes CYP2C19 and CYP2D6, with 87% showing some potential for actionable insights.
- The use of advanced genetic sequencing helped identify significant genetic variations that could affect treatment decisions, suggesting that early pharmacogenomic testing might improve medication prescribing and patient outcomes in psychiatric care.
Nucleotide excision repair (NER) removes DNA helix-distorting lesions induced by UV light and various chemotherapeutic agents such as cisplatin. These lesions efficiently block the elongation of transcription and need to be rapidly removed by transcription-coupled NER (TC-NER) to avoid the induction of apoptosis. Twenty-nine genes have been classified to code for proteins participating in nucleotide excision repair (NER) in human cells.
View Article and Find Full Text PDF