Publications by authors named "Hailati Juledezi"
Background: This study aimed to identify the association of cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator interferon genes (cGAS-STING) pathway with heart failure (HF) in atrial fibrillation (AF) patients.
Methods: We prospectively enrolled 106 AF patients without evidence of HF. The serum levels of 2'3'-cyclic GMP-AMP (2'3'-cGAMP) and interleukin (IL)-1β were measured by enzyme-linked immunoassay (ELISA).
Background: In myocardial ischemia-reperfusion injury, myocardial damage is aggravated when blood perfusion is restored in myocardial infarction. Ubiquitin-specific protease 11 (USP11), a deubiquitinating enzyme, could remove the ubiquitination of substrate proteins and regulate protein stability, thereby affecting multiple pathological processes.
Aims: To investigate the potential function of USP11 in myocardial ischemia-reperfusion injury and its underlying mechanisms.
Aims: To investigate the different risk factors among different subtypes of patients with acute coronary syndrome (ACS).
Methods: A total of 296 patients who had ACS were retrospectively enrolled. Blood and echocardiographic indices were assessed within 24 hours after admission.
LncRNA Gm4419 Regulates Myocardial Ischemia/Reperfusion Injury Through Targeting the miR-682/TRAF3 Axis.
J Cardiovasc Pharmacol
September 2020
Myocardial cell death during acute myocardial infarction occurs because of acute ischemia, persistent ischemia, reperfusion-associated injury, and the inflammatory infiltrate as a response to cell necrosis. In the present study, quantitative real-time PCR showed that lncRNA Gm4419 was highly upregulated in ischemia/reperfusion myocardial tissues and hypoxia/reoxygenation H9C2 cells, whereas miR-682 was downregulated. Knocking down Gm4419 with sh-Gm4419 resulted in the rescue of myocardial infarction and apoptosis induced by ischemia/reperfusion or hypoxia/reoxygenation.
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- - This study examines how certain genetic variations (polymorphisms) in the P-selectin gene (rs1800807 and rs1800808) relate to levels of soluble P-selectin (sPs) in ethnic groups (Han, Uygur, and Kazakh) in Xinjiang, China, particularly in patients with atrial fibrillation (AF) and thromboembolism (TE).
- - A total of 1,943 participants were included, with various combinations of patients and healthy individuals from the three ethnic groups, and the researchers used Polymerase Chain Reaction and ELISA to analyze genetic variations and measure plasma levels of sPs.
- - The findings revealed that specific genotypes had significantly different sPs