This study introduces a novel landfill cover material, employing lake sediment as a substrate, stabilised with fly ash, slag, desulfurisation gypsum and construction waste. The mechanical properties, including shear strength parameters, unconfined compressive strength, hydraulic conductivity, volumetric shrinkage, and water content, of the solidified sludge were evaluated. The microscopic mechanism of the solidified sludge were investigated through XRD, FTIR, and SEM-EDS techniques.
View Article and Find Full Text PDFMitochondrial dysfunction, a hallmark of immune cell failure, affects the antitumor effects of immune cells through metabolic reprogramming, fission, fusion, biogenesis, and immune checkpoint signal transduction of mitochondria. According to researchers, restoring damaged mitochondrial function can enhance the efficacy of immune cells. Nevertheless, the mechanism of mitochondrial dysfunction in immune cells in patients with cancer is unclear.
View Article and Find Full Text PDFBackground: Various inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein-to-albumin ratio (CAR), have been linked to the effectiveness of immunotherapy in multiple types of malignancies. We investigated how these inflammatory markers affect the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) receiving immunotherapy.
Methods: The databases PubMed, Embase, and Cochrane were systematically searched up until March 26, 2024, to identify relevant literature.
Purpose: This study aims to investigate the effects of chest wall bolus in intensity-modulated radiotherapy (IMRT) technology on clinical outcomes for post-mastectomy breast cancer patients.
Materials And Methods: This retrospective study included patients with invasive carcinoma ((y)pT0-4, (y)pN0-3) who received photon IMRT after mastectomy at the Affiliated Hospital of Qingdao University from 2014 to 2019. The patients were divided into two groups based on whether they received daily bolus application or not, and the baseline characteristics were matched using propensity score matching (PSM).
Background: With regard to head and neck squamous cell carcinoma (HNSCC), its occurrence and advancement are controlled by genetic and epigenetic anomalies. PIWI-interacting RNAs (piRNAs) are recognized with significance in tumor, but the precise molecular mechanisms of piRNAs in HNSCC largely remain undisclosed.
Methods: Differentially expressed piRNAs were identified by RNA sequencing.
Polymers (Basel)
April 2024
The epoxy foam material filled with an absorbing agent effectively absorbs electromagnetic waves. In this study, epoxy resin was used as the matrix, and acetylene carbon black was used as the magnetic absorbing agent to prepare an absorbing foam material (epoxy/CB). The microstructure of acetylene carbon black (CB) and its distribution in epoxy resin, as well as the effects of pre-polymerization time and CB content on the foam structure, were systematically characterized.
View Article and Find Full Text PDFThe application of absorbing materials for electromagnetic shielding is becoming extensive, and the use of absorbents is one of the most important points of preparing absorbing foam materials. In this work, epoxy resin was used as the matrix and carbonyl iron powder (CIP) was used as the absorbent, and the structural absorbing foam materials were prepared by the ball mill dispersion method. Scanning electron microscopy showed that the CIP was evenly dispersed in the resin matrix.
View Article and Find Full Text PDFOxaliplatin (OXA)-based chemotherapy is one of the first-line treatments for advanced gastric cancer. However, the potential risk for chemotherapy-induced hepatic injury can hinder its effectiveness. Polyene phosphatidylcholine (PPC) is often used as a hepatoprotective agent to counter OXA-induced hepatic injury; however, its impact on the antitumour effectiveness of OXA remains uncertain.
View Article and Find Full Text PDFAn advanced nanoplatform was developed by integrating catalytic hairpin assembly (CHA) with glutathione-responsive nanocarriers, enabling superior imaging of dual cancer-related miRNAs. Two distinct CHA circuits for the sensing of miRNA-21 and miRNA-155 were functionalized on biodegraded MnO. In the presence of GSH and the corresponding miRNAs, the degraded MnO released the DNA cargos, activating the CHA circuits and recovering the fluorescence.
View Article and Find Full Text PDFBackground: Head and neck cancers are a heterogeneous, aggressive, and genetically complex collection of malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx, paranasal sinuses and salivary glands, which are difficult to treat. Regional lymph nodes metastasis is a significant poor prognosis factor for head and neck squamous cell carcinoma. Metastasis to the regional lymph nodes reduces the 5-year survival rate by 50% compared with that of patients with early-stage disease.
View Article and Find Full Text PDFWorld J Clin Cases
November 2023
Background: SMARCB1/INI-1 deficient sinonasal carcinoma (SDSC) is a rare subset of sinonasal undifferentiated carcinoma with a poor prognosis. Here, we present two case reports of SDSC patients. We also review the literature on this tumor.
View Article and Find Full Text PDFBackground: Gastric cancer (GC) ranks as the fifth most prevalent malignancy and the second leading cause of oncologic mortality globally. Despite staging guidelines and standard treatment protocols, significant heterogeneity exists in patient survival and response to therapy for GC. Thus, an increasing number of research have examined prognostic models recently for screening high-risk GC patients.
View Article and Find Full Text PDFIntroduction: The efficacy of postoperative radiotherapy (PORT) is still unclear in non-small cell lung cancer (NSCLC) patients with pIIIA-N2 disease. Estrogen receptor (ER) was proven significantly associated with poor clinical outcome of male lung squamous cell cancer (LUSC) after R0 resection in our previous study.
Methods: A total of 124 male pIIIA-N2 LUSC patients who completed four cycles of adjuvant chemotherapy and PORT after complete resection were eligible for enrollment in this study from October 2016 to December 2021.
Background: Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. Our study assessed the prognosis and recurrence pattern of different radiotherapy volumes after temozolomide-based chemoradiation in our institution.
Methods: The treatment plans were classified into two groups, the plan 1 intentionally involved the entire edema area while plan 2 did not.
The performance of chemical sensors is dominated by the perception of the target molecules sensitive materials and the conduction of sensing signals through transducers. However, sensing and transduction are spatially and temporally independent in most chemical sensors, which poses a challenge for device miniaturization and integration. Herein, we proposed a sensing-transducing coupled strategy by embedding the high piezoresponse Sm-PMN-PT ceramic ( = ∼1500 pC N) into a moisture-sensitive polyetherimide (PEI) polymer matrix electrospinning to conjugate the humidity perception and signal transduction synchronously and sympatrically.
View Article and Find Full Text PDFHead and neck squamous cell carcinoma (HNSCC) is characterized by an immunosuppression environment and necessitates the development of new immunotherapy response predictors. The study aimed to build a prognosis-related competing endogenous RNA (ceRNA) network based on immune-related genes (IRGs) and analyze its immunological signatures. Differentially expressed IRGs were identified by bioinformatics analysis with Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and ImmPort databases.
View Article and Find Full Text PDFRecovery phosphorus (P) from P-contaminated wastewater is an efficient and environmentally friendly mean to prevent water pollution and alleviate the P shortage crisis. In this study, oyster shell as calcium sources and peanut shells as carbon sources (mass ratio 1:1) were used to prepare a novel Ca-modified biochar (OBC) via co-pyrolysis, and its potential application after P adsorption as a P biofertilizer for soil was also investigated. The results shown that OBC had a remarkable P adsorption capacity from wastewater in a wide range of pH 4−12.
View Article and Find Full Text PDFBackground: Lung squamous cell carcinoma (LUSC) represents 30% of all non-small cell lung carcinoma. Targeted therapy is not sufficient for LUSC patients because of the low frequency of targeted-effective mutation in LUSC whereas immunotherapy offers more options for patients with LUSC. We explored a ferroptosis-related prognostic signature that can potentially assess the prognosis and immunotherapy efficacy of LUSC patients.
View Article and Find Full Text PDFObjectives: G-protein-coupled receptor 120 (GPR120) is a long-chain unsaturated fatty acid receptor, which regulates glucose metabolism and lipid. To date, there are disputes on the roles of GPR120 in the pathogenesis of cancer. Besides, little is known about its roles in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC).
View Article and Find Full Text PDFIn order to prepare a new type of landfill covering material for closure, we used industrial calcium-containing waste (slag, desulfurised gypsum and fly ash) to modify the municipal dewatered sludge. Shear, infiltration and rainfall infiltration model tests were performed to obtain the shear strength parameters of the modified sludge, the hydraulic conductivity during the wet-dry cycle, and the service performance against rainfall breakdown to evaluate the service performance of the modified sludge cover (MSC). Comprehensive characterisation of the modified sludge was analysed by XRD, FTIR and SEM-EDS to revealed the mineral structure, microstructure, and modification mechanism of the sludge.
View Article and Find Full Text PDFWith the rapid development of electronic technology and modern radar detection system, there is increasingly urgent demand for microwave absorbing composites working efficiently in the low frequency range (e.g., 1−2 GHz).
View Article and Find Full Text PDFType IIA topoisomerase (TOP2A) is upregulated in hepatocellular carcinoma (HCC) and its expression is positively correlated with poor prognosis. However, the underlying molecular mechanism of this connection are poorly understood. Hence, the present work aimed to examine the possible mechanisms which may be useful in identifying a potential therapeutic strategy.
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