With the rapid development of the global economy and the continuous consumption of fossil resources, sustainable and biodegradable natural biomass has garnered extensive attention as a promising substitute for synthetic polymers. Due to their hierarchical and nanoscale structures, natural biopolymers exhibit remarkable mechanical properties, along with excellent innate biocompatibility and biodegradability, demonstrating significant potential in various application scenarios. Among these biopolymers, proteins and polysaccharides are the most commonly studied due to their low cost, abundance, and ease of use.
View Article and Find Full Text PDFBackground: Despite hip function typically deteriorating in the post-collapse stage of osteonecrosis of the femoral head (ONFH), some patients can still demonstrate long-term favorable hip function, a state termed "survival with collapse". This study aims to identify the characteristics of patients suitable for "survival with collapse" in cases of ONFH.
Methods: This cross-sectional study included 65 patients (87 hips) diagnosed with post-collapse ONFH for ≥ 3 years (average 9.
Objective: Alzheimer's disease (AD) pathology is featured by the extracellular accumulation of amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles in the brain. We studied whether Aβ and tau accumulation are independently associated with future cognitive decline in the AD continuum.
Methods: Data were acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI) public database.
Background: Osteoking has been extensively used for the treatment of knee osteoarthritis (KOA). However, it is lack of high-quality evidence on the clinical efficacy of Osteoking against KOA and the comparison with that of nonsteroidal anti-inflammatory drugs (NSAIDs).
Aims: To evaluate the efficacy and safety of Osteoking in treating KOA.
Flexible, air permeable and elastic self-powered sensors for human motion monitoring and assisted medical rehabilitation have recently become a hot research topic. However, most current piezoelectric sensors can not account for many characteristics. Addressing this challenge, an all-textile piezoelectric sensor (ATPS) based on 3D structured knitted fabric electrodes is reported.
View Article and Find Full Text PDFWith the advent of the intelligent age and people's higher pursuit of health, wearable sensors with functions of health monitoring and assisting physical rehabilitation are increasingly favored by consumers. Wherein, highly stretchable flexible sensors show promising potential, but the unstable conductivity under large strains remains a great challenge to develop flexible wearable sensors with both a wide work range and strain insensitivity. Based on this, a MXene/CNTs/TPU flexible resistive sensor (MCT/FRS) with hierarchical structure inspired by the annual ring was proposed.
View Article and Find Full Text PDFIn order to withstand high-temperature environments, ultra-high molecular weight polyethylene (UHMWPE) fibers with cooling properties are being increasingly used in personal thermal management textiles during the summer. However, there is relatively little research on its combination with knitting. In this paper, we combine UHMWPE fiber and knitting structure to investigate the impact of varying UHMWPE fiber content and different knitting structures on the heat and humidity comfort as well as the cooling properties of fabrics.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2023
Flexible and wearable devices are drawing increasing attention due to their promising applications in energy harvesting and sensing. However, the application of wearable devices still faces great challenges, such as flexibility, repeatability, and biodegradability. Biopiezoelectric materials have been regarded as favorable energy-harvesting sources due to their nontoxicity and biocompatibility.
View Article and Find Full Text PDFBackground: Despite extensive work to identify diagnostic plasma markers for Parkinson's disease (PD), there are still no accepted and validated surrogate biomarkers. Mitophagy-associated proteins (MAPs), including PTEN-induced putative kinase 1 (PINK1), Parkin, phosphoglycerate mutase 5 (PGAM5), BCL2 interacting protein 3 (BNIP3), and phosphorylated-TBK1 (p-TBK1), are, to our best knowledge, not well studied as a panel of biomarkers of neurodegeneration in PD.
Methods: The study population comprised 116 age-matched controls (HC), 179 PD patients, alongside and 90 PD syndromes (PDs) divided between two cohorts: (i) the modeling cohort (cohort 1), including 150 PD, 97 HC, and 80 PDs; and (ii) the validated cohort (cohort 2), including 29 PD, 19 HC, and 10 PDs.
The safety of groundwater and drinking water is directly related to the well-being of human beings and ecosystems. On-site monitoring and timely response to heavy metals in these water sources are crucial for water supply security. Fluorescent probes combined with machine learning technology have been applied to on-site detection of heavy metals.
View Article and Find Full Text PDFCNS Neurosci Ther
February 2024
A hybrid aperiodic-coded Brillouin optical correlation domain analysis (HA-coded BOCDA) fiber sensor is proposed to achieve long-range high-spatial-resolution distributed measurement. It is found that high-speed phase modulation in the BOCDA actually forms a special energy transformation mode. This mode can be exploited to suppress all detrimental effects parasitized in a pulse coding-induced cascaded stimulated Brillouin scattering (SBS) process and thereby enable the HA-coding to reach its full potential to improve the BOCDA performance.
View Article and Find Full Text PDFElectrospinning technology has attracted extensive attention in recent decades and is widely used to prepare nanofiber membranes from hundreds of polymers. Polyvinyl formal acetal (PVFA), as a polymer with excellent properties such as high strength and heat resistance, is not reported on the electrospun water treatment membrane. In this paper, the preparation process of electrospun PVFA nanofiber membrane is optimized, and the effect of sodium chloride (NaCl) addition on the physical and mechanical properties and microfiltration performance of nanofiber membrane is also explored.
View Article and Find Full Text PDFPolymers (Basel)
January 2023
In the field of water purification, membrane separation technology plays a significant role. Electrospinning has emerged as a primary method to produce nanofiber membranes due to its straightforward, low cost, functional diversity, and process controllability. It is possible to flexibly control the structural characteristics of electrospun nanofiber membranes as well as carry out various membrane material combinations to make full use of their various properties, including high porosity, high selectivity, and microporous permeability to obtain high-performance water treatment membranes.
View Article and Find Full Text PDFObjective: At present, there is no consensus or guidance on indications for osteonecrosis of the femoral head (ONFH) patients to receive hip arthroplasty (THA) treatment. This study aims to explore the factors that influence the decision-making for THA in patients with ONFH, and to provide references for clinical decision for ONFH patients to be indicated for THA or hip preservation.
Methods: This retrospective case-control study involved data for ONFH patients from July 2016 to October 2021 from the China Osteonecrosis of the Femoral Head Database (CONFHD).
Biosensors (Basel)
December 2022
Front Aging Neurosci
October 2022
Background: We aimed to examine whether plasma-derived phosphoglycerate mutase 5 (PGAM5) can be a biomarker for Parkinson's disease (PD) diagnosis as well as its association with the severity of motor/non-motor manifestations of PD.
Methods: We enrolled 124 patients with PD (PD group) and 50 healthy controls (HC group). We measured plasma PGAM5 levels using a quantitative sandwich enzyme immunoassay.
In phase-sensitive optical time domain reflectometry (-), false phase peaks caused by interference fading have been observed experimentally; however, the statistical law has not yet been disclosed. In this work, after clarifying that the false phase peaks originate from the phase hopping of demodulated phase noise during the unwinding process, we define the phase hopping rate (PHR) to evaluate the degree of fading and study the quantitative relationship between the PHR and signal-to-noise ratio (SNR) of the measured signal through theoretical derivation and experimental verification. In addition, a moving rotated-vector-average (MRVA) method is proposed to suppress the fading and eliminate the false phase peaks.
View Article and Find Full Text PDFObjective: Although tongue manifestation is a vital component of Traditional Chinese Medicine (TCM), relevant research on patients with osteonecrosis of the femoral head (ONFH) is still lacking. This study will explore the characteristic tongue manifestation of ONFH patients to inform future research and clinical practice.
Methods: This is a cross-sectional study.
Introduction: To explore the combined diagnostic value of plasma Lewy body-associated proteins (p-Asyn at ser129, total α-syn, and oligomeric α-syn) for the diagnosis of PD versus healthy controls (HCs) and other PD syndromes (PDs), as well as clinical characteristics prediction.
Methods: This study included 145 participants: 79 patients with PD, 24 patients with PDs, and 42 HCs. A panel of plasma levels of p-Asyn, total α-syn, and oligomeric α-syn was measured by enzyme-linked immunosorbent assay (ELISA).