New Insights into the Pathogenesis of Alcoholic Liver Disease Based on Global Research.

Background And Aims: Alcoholic liver disease (ALD) is the leading cause of death among alcohol-related diseases, yet its pathogenesis remains incompletely understood. This article employs data mining methods to conduct an indepth study of articles on ALD published in the past three decades, aiming to elucidate the pathogenesis of ALD.

Methods: Firstly, articles related to the pathogenesis of ALD were retrieved from the Web of Science (WOS) database.

[Analysis of Heavy Metal Sources in Farmland Soil of Sewage Irrigation and Industrial Complex Area Based on APCS-MLR and PMF].

The contents of eight heavy metals （Cr, Ni, Cu, Zn, Cd, Pb, As, and Hg） were determined based on the surface soil samples of sewage irrigation and industrial complex in Kaifeng City. The absolute factor analysis-multiple linear regression （APCS-MLR） model and positive matrix factorization （PMF） model were used to analyze the sources and contribution rates of heavy metals in soil combined with correlation analysis and systematic cluster analysis. The results showed that： ① The average values of （Cr）, （Ni）, （Cu）, （Zn）, （Cd）, （Pb）, （As）, and （Hg） in the study area were 52.

[Source Apportionment and Health Risk Assessment of Heavy Metals in Dust Around Bus Stops in Kaifeng City Based on APCS-MLR Model].

In order to reveal the influence of urban transportation systems on the quality of urban ecological environment, this study selected surface dust from bus stops, which is strongly disturbed by transportation, as the research object. The contents of eight heavy metals (V, Cr, Co, Ni, Cu, Zn, Cd, and Pb) in the dust were determined through inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma atomic emission spectroscopy (ICP-ASE). The spatial distribution characteristics and pollution levels of the eight heavy metals in the dust were analyzed using the geo-accumulation index method.

[Soil Heavy Metal Contamination, Sources, and Health Risk of Typical Drinking Water Sources in the Suspended Reach of the Lower Yellow River].

With the implementation of ecological protection and a high-quality development strategy in the Yellow River Basin, the environmental conditions around the Yellow River have attracted wide attention from scholars. In this study, the soil of drinking water sources(Heichi and Liuchi) in the typical suspended reach of the lower reaches of the Yellow River was selected as the research object. The geo-accumulation index and pollution load index were used to analyze the pollution characteristics of seven heavy metals(Cr, Ni, Cu, Zn, Cd, Pb, and As), and correlation analysis, principal component analysis, and absolute factor score-multiple linear regression(APCS-MLR) were employed to reveal the sources of soil heavy metals from both qualitative and quantitative perspectives.

[Pollution Characteristics and Source Analysis of Heavy Metals in Soils in Yellow River Cultural Park Based on APCS-MLR and PMF Receptor Model].

With open spaces and good ecological environments, urban parks have become the first choice for the leisure and entertainment of many people. Therefore, the quality of park soil environments has gradually attracted the extensive attention of scholars. In this study, we take the Yellow River Cultural Park, a typical human disturbance area in the lower reaches of the Yellow River, as the research area to discuss the characteristics and sources of heavy metal pollution in the soil.

Combination of UNMIX, PMF model and Pb-Zn-Cu isotopic compositions for quantitative source apportionment of heavy metals in suburban agricultural soils.

Quantitative identification of heavy metals (HM) sources in soils is key to prevention and control of heavy metal pollution. In this study, UNMIX, PMF (Positive matrix factorization) model and Pb-Zn-Cu isotopic compositions were combined to quantitatively identify heavy metal sources in a suburban agricultural area of Kaifeng, China. Using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) and ICP-MS, we measured Pb, Zn and Cu stable isotopic compositions, HM concentrations and HM chemical fractions in studied soils, as well as potential sources around the highly polluted site, including total suspended particle, compound fertilizer, irrigated river water and sediments.

Phosphate removal from aqueous solution by Fe-La binary (hydr)oxides: characterizations and mechanisms.

In this study, Fe-La binary (hydr)oxides were prepared by a co-precipitation method for phosphate removal. Various techniques, including secondary electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), powder X-ray diffraction (p-XRD), and Brunauer-Emmett-Teller (BET) surface area analysis, were employed to characterize the synthesized Fe-La binary (hydr)oxides. Batch experiments indicated that the performance of phosphate removal by Fe-La binary (hydr)oxides was excellent and increased with increasing the concentrations of La.

Occurrence, source apportionment, and potential human health risks of metal(loid)s and PAHs in dusts from driving school campuses in an urban area of Henan, China.

Concentrations, health risks, and sources of 9 metal(loid)s (As, Cd, Co, Cr, Cu, Hg, Ni, Pb, and Zn) and 16 PAHs in dusts collected from the 29 driving school campuses in the urban area of Kaifeng, Henan Province, China, were evaluated. The health risks due to exposure to these pollutants in dusts were assessed under three different scenarios (working for 10 years, 20 years, and 30 years in driving schools), using the health risk assessment model developed by US EPA. The results indicated that the mean concentrations for As, Cd, Cr, Cu, Hg, Pb, and Zn were higher than the local dust background except Co and Ni.

[Effects of combined administration of Radix Angelicae Sinensis and hydrocortisone on the therapeutic action in the murine asthma model].

Objective: To investigate the effects of Radix Angelicae Sinensis (RASI) and hydrocortisone combination on the murine asthma model and the mechanism.

Methods: BALB/c mice were randomly divided into control group, blood stasis model group, asthma model group, HSS group, RASI group and RASI+HSS group (=12). Ovalbumin (OVA) was used to replicate mice asthma model and hydrocortisone sodium succinate (HSS) to copy blood stasis model.

[Effect of Yuyin Ruangan Granule on TGF-β1 expression in hepatic fibrosis rats].

Objectives: To observe the preventive and therapeutic action of Yuyin Ruangan Granule (YRG, Traditional Chinese Medicine) in hepatic fibrosis rats model and its effect on transforming growth factor-β1 (TGF-β1) expression.

Methods: The Wistar rats were randomly divided into 6 group (=10), and the model of hepatic fibrosis rats was established by subcutaneous injected with carbon tetrachloride (CCL4), fed on high-fat diet and 20% ethanol for 6 weeks, to survey the effect and mechanism of YRG preventing hypatic fibrosis by detecting liver function (the activity of alanine aminotransferase(ALT), aspartate aminotransferase(AST), etc.) of liver fibrosis rats, liver fibrosis indicators (hyaluronic acid, Ⅲ procollagen, type IV collagen, laminin and hepatic pathology, etc.

[Compositions, Sources and Health Risks of Polycyclic Aromatic Hydrocarbons (PAHs) in Surface Dusts from Driving-schools in a City of Henan Province, China].

The contamination of polycyclic aromatic hydrocarbons (PAHs) in surface dusts attracts great attentions due to their properties of threatening human health. Twenty-nine surface dust samples were collected from driving-schools in a city of Henan. Concentrations of 16 priority PAHs were analyzed by gas chromatography-mass spectrometry (GC-MS).

[Preliminary pharmacodynamics study on antiasthmatic action of butylphthalide in guinea pig].

Objective: To study the anti-asthmatic effects of butylphthalide in guinea pig.

Methods: This research included isolated tra-cheal smooth muscle and in vivo animal experiments. Antispasmodic effects of butylphthalide at the concentrations of 1, 10, 100 mg/L were observed through spasmodical tracheal smooth muscle of guinea pig induced by acetylcholine or histamine (=10).

[Effects of butylphthalide on bronchial asthma in guinea pigs and involvement of endothelin].

Objective: To study the effects of butylphthalide on bronchial asthma in guinea pigs, and investigate the involvement of endothelin.

Methods: In guinea pigs, bronchial asthma was induced by injection of ovalbumin (OVA) and provoked by inhalation of OVA, and the effects of butylphthalide on asthma were evaluated through the changes it induced by OVA, pulmonary function, endothelin-1 (ET-1) contents and activity of endothelin converting enzyme-1 (ECE-1) in bronchoalveolar lavage fluid (BALF), serum and lung tissue, and the gene expression of ET-1 in lung tissue.

Results: Butylphthalide significantly improved pulmonary function, lowered asthmatic behavior score, inhibited the activity of ECE-1, and reduced ET-1 gene expression level in lung tissue.

[Assessment of Heavy Metal Pollution and its Health Risk of Surface Dusts from Parks of Kaifeng, China].

Fifty-two dust samples were collected from four parks [Longting Park (P(L)), Tieta Park (P(T)), Qingmingshanghe Park (P(Q)), Xiangguosi Park (P(X))] located in Kaifeng City, China. Concentrations of Hg and As in dusts were measured by atomic fluorescence spectrometry (AFS), while Cr, Cu, Zn, Pb, Ni and Cd were analyzed by inductively coupled plasma mass-spectrometry (ICP-MS). The heavy metal pollution of dust was assessed using Geo-accumulation index (Igeo) and pollution load index (PLI).

[Separation and identification of endophytic fungi from desert plant Cynanchum komarovii].

Objective: The research aimed to investigate the entophytic fungal community of Cynanchum Komarrovii, including the biodiversity in different organs and the correlations with ecological environment. Endophytic fungi with patent bioactivity were also rapidly screened.

Method: PDA medium was used to isolate and purify the endophytic fungi from C.

Rapid determination of phenolic compounds in water samples by alternating-current oscillopolarographic titration.

A rapid, simple and sensitive method was demonstrated for the determination of phenolic compounds in water samples by alternating-current oscillopolarographic titration. With the presence of sulfuric acid, phenol could be transferred into a nitroso-compound by reacting with NaNO2. The titration end-point was obtained by the formation of a sharp cut in the oscillopolarographic with infinitesimal NaNO2 on double platinum electrodes.