Cell Function Graphics: TOGGLE delineates fate and function within individual cell types via single-cell transcriptomics.

Functional RNA plays a crucial role in regulating cellular processes throughout the life cycle of a cell. Identifying functional changes at each stage-from inception to development to maturation, functional execution, and eventual death or pathological transformation-often requires systematic comparisons of functional expression across cell populations. However, because cells of the same type often exhibit similar gene expression patterns regardless of function or fate, it is challenging to distinguish the stages of cellular fate or functional states within the same cell type, which also limits our understanding of cellular memory.

Designed Synthesis and Electrochemical Performance Regulation of the Hierarchical Hollow Structure CuS/CuS/NC Anode for Hybrid Supercapacitors.

Copper-based compounds have attracted increasing attention as electrode materials for rechargeable devices, but their poor conductivity and insufficient stability inhibit their further development. Herein, an effective method has been proposed to improve the electrochemical properties of the copper-based electrodes by coating carbon materials and generating unique micro/nanostructures. The prepared CuS/CuS/NC with hierarchical hollow structure possesses excellent electrochemical performance, attributing to the composition and structure optimization.

Naotaifang III Protects Against Cerebral Ischemia Injury Through LPS/TLR4 Signaling Pathway in the Microbiota-Gut-Brain Axis.

Background: Ischemic stroke (IS) is a leading cause of mortality worldwide. Naotaifang III is a new Chinese herbal formula to treat IS. Previous studies have shown that and in Naotaifang III were able to regulate the imbalance of intestinal microbiota during cerebral ischemia injury.

Strategy for Co-Enhancement of Remanence-Coercivity of RE-Fe-B Sintered Magnets with High Ce-Content: Appropriate La Substitution.

The development of low-cost RE-Fe-B sintered magnets with large La/Ce content is of great significance for the balanced utilization of rare earth (RE) resources, but it is limited by reduced magnetic properties. In this work, the coercivity (H ), remanence (B ), maximum energy product [(BH) ], and temperature stability are simultaneously enhanced for magnets with LaCe accounting for 40 wt% of the total RE. The synergistic regulation of the REFe phase, Ce-valence, and grain boundaries (GBs) in RE-Fe-B sintered magnets is realized for the first time by introducing appropriate La elements.

Artemisinin inhibits angiogenesis by regulating p38 MAPK/CREB/TSP-1 signaling pathway in osteosarcoma.

Osteosarcoma is the most common bone tumor and characterizes a high metastatic potential. In osteosarcoma, angiogenesis is reported to be closely associated with tumor metastasis. Understanding the underlying mechanisms and accordingly developing therapeutic strategies are urgently desired.

[Effects of human urine-derived stem cells combined with chondroitinase ABC on the expressions of nerve growth factor and brain-derived neurotrophic factor in the spinal cord injury].

Objective: To explore the effects of human urine-derived stem cells (hUSCs) and hUSCs combined with chondroitinase ABC (chABC) on the expressions of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the spinal cord injury (SCI) of rats, and to investigate the underlying mechanism.

Methods: hUSCs were cultured from human urine, and their phenotypes were detected by flow cytometry. The SCI model of rats were made via Allen method.

Signal transducer and activator of transcription 3 regulates CCAAT-enhancer-binding homologous protein expression in osteoblasts through upregulation of microRNA-205.

The transcription factor, CCAAT-enhancer-binding protein homologous protein (CHOP), is induced by endoplasmic reticulum-stress and mediates programmed cell death. In osteoblasts, CHOP overexpression increases the rate of apoptosis, leading to osteoblastic dysfunction. However, the regulatory mechanisms underlying CHOP expression remain unclear.

The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2).

Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is a member of the MrgX family.

Propidium iodide (PI) stains Nissl bodies and may serve as a quick marker for total neuronal cell count.

Propidium iodide (PI) reacts with both DNA and RNA and is a commonly used fluorescent reagent for nucleic acid staining. The aim of the study was to compare the cellular staining patterns of PI with that of Nissl staining in rat nervous tissues and to report a modified staining method that selectively labels Nissl bodies in neurons. Cryosections and paraffin sections of different tissues of normal Sprague-Dawley rats, including trigeminal ganglia, dorsal root ganglia, spinal cord, liver, and small intestine, were stained by either PI or the hematoxylin and eosin method.

Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.

Background: Genes involved in male reproduction are often the targets of natural and/or sexual selection. SCML1 is a recently identified X-linked gene with preferential expression in testis. To test whether SCML1 is the target of selection in primates, we sequenced and compared the coding region of SCML1 in major primate lineages, and we observed the signature of positive selection in primates.

[Study relationship of Haas formation potential and organic molecular weight distribution in the process of O3/BAC].

We investigated the removal of organic matters with different molecular weight (MW) and HAAs formation potential composed of organic matters with different MW in the two processes of 03/BAC and micro-aeration/BAC, and discussed the characteristic of forming HAAs by organic matters with different MW. The results indicated that more than 90% of organic matters with >30 x 10(3) molecular weight could be removed in the process of O3/BAC. In the water treated by the two processes of O3/BAC and micro-aeration/BAC, the percentage of organic matters with < 10(3) MW exceeded 50%, 10 x 10(3)-30 x 10(3) MW was in 20%-30% based on UV254 value as token of organic matters.

[Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation].

The ozone oxidation of endocrine disruptor (bisphenol A) in drinking water was investigated. With the initial concentration of 1.0 mg/L, the removal efficiency of BPA (bisphenol A) could be measure up to 70%, 82%, 90% when the dosage of ozone was 1 mg/L, 1.