MnO-based dual channel surface plasmon resonance fiber sensor for trace glutathione and refractive index detection.

Glutathione (GSH) plays vital role in human biological systems, so its rapid and sensitive detection is necessary for health condition monitoring. In this work, a simple structure for dual channel GSH and refractive index (RI) detection is proposed. By introducing Au-MnO thin film coating on the fiber surface for the first time, GSH solution would lead to the dissolution of MnO, the change in GSH levels could be monitored over a short period in channel 2.

Sleep duration and age-related macular degeneration: a cross-sectional and Mendelian randomization study.

Purpose: To investigate the association between sleep duration and age-related macular degeneration (AMD).

Design: Cross-sectional study, bidirectional two-sample Mendelian randomization (MR). For cross-sectional analysis, we used survey data of 5,481 participants aged ≥40 years from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES).

Metagenomic analysis reveals antibiotic resistance profiles in tissue samples from patients with diabetic foot infections.

Objectives: Treating patients with diabetic foot infection (DFI) is challenging because of high rates of antibiotic resistance. Therefore, to administer a suitable antibiotic treatment, it is necessary to know the antibiotic resistance patterns in DFIs.

Methods: To explore this question, we selected metagenomic data of 36 tissue samples from patients with DFI in the National Center for Biotechnology Information Sequence Read Archive database.

Unimolecular micelles from star-shaped block polymers by photocontrolled BIT-RDRP for PTT/PDT synergistic therapy.

Unimolecular micelles (UIMs) exhibit promising potential in the precise diagnosis and accurate treatment of tumor tissues, a pressing problem in the field of medical treatment, because of their perfect stability in the complex and variable microenvironment. In this study, porphyrin-based four-armed star-shaped block polymers with narrow molar mass dispersity ( = 1.34) were facilely prepared by photocontrolled bromine-iodine transformation reversible-deactivation radical polymerization (BIT-RDRP).

Two Pyroptosis-Related Subtypes with Distinct Immune Microenvironment Characteristics and a Novel Signature for Predicting Immunotherapy Response and Prognosis in Uveal Melanoma.

Purpose: Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults with poor prognosis. Pyroptosis is a well-known form of programmed cell death. However, pyroptosis has not been sufficiently discussed in UM.

Evaluating the Effect of Circ-Sirt1 on the Expression of SIRT1 and Its Role in Pathology of Pulmonary Hypertension.

Pulmonary arterial hypertension (PAH) is a disease that plagues a major portion of the world's population, and there is currently no effective cure for this ailment. The proliferation and migration of pulmonary artery smooth muscle cells (PASMC) are known to be the pathological basis of pulmonary vascular remodeling in pulmonary hypertension. Studies in the past have shown involvement of CircRNA in the pathology of pulmonary as well as cardiovascular diseases.

Flexible Metal Electrodes by Femtosecond Laser-Activated Deposition for Human-Machine Interfaces.

Flexible metal electrodes are essential for flexible electronics, where the main challenge is to obtain mask-free patterned metals directly on substrates such as poly(dimethylsiloxane) (PDMS) at low cost. This work highlights a feasible strategy named femtosecond laser-activated metal deposition for electroless deposition of metals (Cu, Ni, Ag, and Au) on PDMS, which is suitable for maskless and low-cost fabrication of metal layers on PDMS and even on other materials of different natures including polyethylene terephthalate, paper, Si, and glass. The electrical conductivity of the PDMS/Cu electrode is comparable to that of bulk Cu.

Facile Synthesis of Unimodal Polymethacrylates with Narrow Dispersity via NIR LED Light-Controlled Bromine-Iodine Transformation Reversible-Deactivation Radical Polymerization.

A facile and clean strategy for synthesizing unimodal polymethacrylates with narrow dispersity (Đ < 1.10) is successfully developed by a near-infrared (NIR) light-emitting diode (LED) light (λ = 740 nm)-controlled in situ bromine-iodine transformation reversible-deactivation radical polymerization system without the use of NIR dyes and expensive catalysts. In this system, alkyl iodide ethyl α-iodophenylacetate (EIPA) initiator is generated in situ by the nucleophilic substitution reaction between an alkyl bromide compound ethyl α-bromophenylacetate and sodium iodide (NaI).

Construction of NIR Light Controlled Micelles with Photothermal Conversion Property: Poly(poly(ethylene glycol)methyl ether methacrylate) (PPEGMA) as Hydrophilic Block and Ketocyanine Dye as NIR Photothermal Conversion Agent.

Polymeric nanomaterials made from amphiphilic block copolymers are increasingly used in the treatment of tumor tissues. In this work, we firstly synthesized the amphiphilic block copolymer PBnMA--P(BAPMA--PEGMA) via reversible addition-fragmentation chain transfer (RAFT) polymerization using benzyl methacrylate (BnMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA), and 3-((tert-butoxycarbonyl)amino)propyl methacrylate (BAPMA) as the monomers. Subsequently, PBnMA--P(APMA--PEGMA)@NIR 800 with photothermal conversion property was obtained by deprotection of the -butoxycarbonyl (BOC) groups of PBAPMA chains with trifluoroacetic acid (TFA) and post-modification with carboxyl functionalized ketocyanine dye (NIR 800), and it could self-assemble into micelles in CHOH/water mixed solvent.

One-Step Photocontrolled Polymerization-Induced Self-Assembly (Photo-PISA) by Using In Situ Bromine-Iodine Transformation Reversible-Deactivation Radical Polymerization.

Polymerization-induced self-assembly (PISA) has become an effective strategy to synthesize high solid content polymeric nanoparticles with various morphologies in situ. In this work, one-step PISA was achieved by in situ photocontrolled bromine-iodine transformation reversible-deactivation radical polymerization (hereinafter referred to as Photo-BIT-RDRP). The water-soluble macroinitiator precursor α-bromophenylacetate polyethylene glycol monomethyl ether ester (mPEG-BPA) was synthesized in advance, and then the polymer nanomicelles (mPEG--PBnMA and mPEG--PHPMA, where BnMA means benzyl methacrylate and HPMA is hydroxypropyl methacrylate) were successfully formed from a PISA process of hydrophobic monomer of BnMA or HPMA under irradiation with blue LED light at room temperature.

Tanshinone IIA protects lens epithelial cells from H O -induced injury by upregulation of lncRNA ANRIL.

Tanshinone IIA is a lipophilic diterpene extracted from the Salvia miltiorrhiza bunge, possessing antiapoptotic and antioxidant activities. The purpose of this study was to explore the effects of Tanshinone IIA on age-related nuclear cataract. Human lens epithelial cell line SRA01/04 was subjected to H O to mimic a cell model of cataract.

The diagnosis and treatment of cardiac lymphangioma: A case report and literature review.

Rationale: Cardiac lymphangioma is a rare disease. Until now, there have been only a few cases of cardiac lymphangioma reported in the literature.

Patient Concerns: We report the case of a 57-year-old female patient with cardiac lymphangioma from atrial septum.

MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells.

Chemoresistance is an inevitable occurrence in lung adenocarcinoma, which has been associated with decreased expression of the phosphatase and tensin homolog deleted on chromosome ten (PTEN). Therefore, it is important to identify novel molecular mechanisms to suppress chemoresistance in lung adenocarcinoma cells. Paclitaxel- and cisplatin-resistant A549 lung carcinoma cell derivatives were developed by long-term serial culture.

[The effect of blue light on human retinal pigment epithelium cells α1D subunit protein expression and vascular endothelial growth factor and basic fibroblast growth factor secretion in vitro].

Objective: To investigate the effect of blue light on human retinal pigment epithelium (RPE) α1D subunit protein expression and its relationship with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) secretion in vitro.

Methods: The fourth generation cultured human RPE cells in vitro were randomly divided into 4 groups, group A (control), group B (exposure to blue light), group C (exposure to blue light+nifedipine), group D [exposure to blue light+(-)Bay K8644]. Cells were exposed to blue light (2 000 ± 500) lx for 6 hours, and cells culture completed 24 hours later.

Cisplatin combined with metformin inhibits migration and invasion of human nasopharyngeal carcinoma cells by regulating E-cadherin and MMP-9.

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis.

[Multi-center clinical trial of FLAMIGEL (hydrogel dressing) for the treatment of residual burn wound].

Objective: To evaluate the effect of FLAMIGEL (hydrogel dressing) on the repair of residual burn wound.

Methods: Sixty burn patients with residual wounds hospitalized in 6 burn units from November 2011 to May 2012 were enrolled in the multi-center, randomized, and self-control clinical trial. Two residual wounds of each patient were divided into groups T (treated with FLAMIGEL) and C (treated with iodophor gauze) according to the random number table.

[Association between both resistin, visfatin and insulin resistance as well as β cell function in the first-degree relatives of type 2 diabetes mellitus].

Objective: To study the association between the levels of serum resistin, visfatin and insulin resistance as well as β-cell dysfunction in the first-degree relatives (FDR) of type 2 diabetes mellitus (T2DM), and to investigate the role of these adipocytokines in pathogenesis of T2DM.

Methods: Serum levels of resistin, visfatin as well as fasting true insulin (FTI), proinsulin (FPI) levels were measured in 71 patients with newly diagnosed T2DM. 55 subjects with IGT/IFG and 174 NGT from first-degree relatives of T2DM, and 114 subjects of NGT without T2DM family history served as control group (NC).

[Serum levels of retinol-binding protein-4 and its association with metabolic syndrome in first-degree relatives of type 2 diabetes mellitus].

Objective: To evaluate serum levels of retinol-binding protein-4 (RBP-4) in first-degree relatives (FDR) of type 2 diabetes mellitus (T2DM) with different glucose tolerance status and to observe its correlation to metabolic syndrome (MS).

Methods: Subjects from FDR of T2DM, including 174 with NGT, 55 with IGT/IFG, and 71 patients with newly diagnosed of T2DM and 114 subjects without diabetic family history as control group [(18 +/- 7) microg/ml vs (22 +/- 8) microg/ml, (NC) [(18 +/- 7) microg/ml vs (22 +/- 8) microg/ml, were recruited. Serum RBP-4 level was measured by radioimmunoassay.