CXCR5CD8 T cells could induce the death of tumor cells in HBV-related hepatocellular carcinoma.

The follicular CXCR5CD8 T cells have recently emerged as a critical cell type in mediating peripheral tolerance as well as antiviral immune responses during chronic infections. In this study, we investigated the function of CXCR5CD8 T cells in HBV-related hepatocellular carcinoma patients. Compared to CXCR5CD8 T cells, CXCR5CD8 T cells presented elevated PD-1 expression but reduced Tim-3 and CTLA-4 expression.

Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8 T cell response and better prognosis in HBV-related hepatocellular carcinoma.

Recent studies suggest that several bacterial species are involved in tumor immunosurveillance and antitumor immunity. The role of bacteria in immune responses in HBV-related hepatocellular carcinoma (HCC) patients is still unknown. In this study, we examined the bacteria-reactive CD8 T cell response in patients with HBV-related HCC.

Preferential Tim-3 expression on Treg and CD8(+) T cells, supported by tumor-associated macrophages, is associated with worse prognosis in gastric cancer.

While infection with H. pylori is a strong risk factor for gastric cancer, most H. pylori-colonized individuals, even those with the high-risk CagA(+)VacA(+) strain, remain asymptomatic over their lifetime.