Publications by authors named "Haidar M"

Article Synopsis
  • Theileria parasites lead to the transformation of bovine leukocytes, causing them to proliferate rapidly and evade cell death.
  • The study investigates mA RNA modifications in T. annulata-infected leukocytes, using sequencing and bioinformatics to analyze these methylation patterns.
  • Findings suggest that mA modifications correlate with leukocyte proliferation rates and may influence cell cycle dynamics, with HIF-1α identified as a potential regulator of these modifications, highlighting the importance of mRNA methylation in the interaction between the parasite and host cells.
View Article and Find Full Text PDF

Conventional imaging techniques, while essential, occasionally fall short in identifying elusive metastatic lesions, leading to delayed diagnoses and compromised patient outcomes. Gallium-68 fibroblast activating protein inhibitor (Ga-FAPI) positron emission tomography/computed tomography (PET/CT), leveraging the distinct affinity of fibroblast activation protein for cancer-associated fibroblasts, emerges as a promising solution to bridge this diagnostic gap. Parotid gland adenocarcinoma is a relatively rare malignancy with metastasis typically occurring in regional lymph nodes and distant sites such as the lungs and bones.

View Article and Find Full Text PDF

Purpose: To measure and validate elevated succinate in brain during circulatory arrest in a piglet model of cardiopulmonary bypass.

Methods: Using data from an archive of 3T H MR spectra acquired in previous in-magnet studies, dynamic plots of succinate, spectral simulations and difference spectra were generated for analysis and validation.

Results: Elevation of succinate during circulatory arrest was observed and validated.

View Article and Find Full Text PDF

Background: While magnetic resonance imaging (MRI) remains the gold standard for morphological imaging, its ability to differentiate between tumor tissue and treatment-induced changes on the cellular level is insufficient. Notably, glioma cells, particularly glioblastoma multiforme (GBM), demonstrate overexpression of chemokine receptor-4 (CXCR4). This study aims to evaluate the feasibility of non-invasive Ga-Cixafor™ PET/CT as a tool to improve diagnostic accuracy in patients with high-grade glioma.

View Article and Find Full Text PDF

Background: The increasing prevalence of obesity and associated cardiovascular diseases (CVDs) in Kuwait requires a comprehensive analysis of its contributing factors and health outcomes. This systematic review and meta-analysis aimed to synthesize the current evidence on the relationship between obesity and CVDs and identify the main factors driving obesity in the Kuwaiti population.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, multiple databases were systematically searched, identifying 980 articles.

View Article and Find Full Text PDF

Introduction: Ectopic adrenocortical adenomas are infrequent adrenal tumors that deviate from their usual location. Herein, we report a case of an ectopic black adrenocortical adenoma situated in the abdominal wall, intricately linked to the head of the pancreas.

Case Presentation: A 27-year-old female presented to the emergency room with severe right iliac pain, nausea, vomiting, and high fever.

View Article and Find Full Text PDF

Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation, and the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In cancer, and particularly in the presence of oncogenic KRAS mutations, in vivo studies concluded that SG increase the resistance of cancer cells to stress.

View Article and Find Full Text PDF
Article Synopsis
  • A 70-year-old man presented with severe symptoms including hiccups, belching, appetite loss, and significant weight loss over three months, prompting further investigation.
  • F-FDG PET/CT imaging revealed a tumor in the right liver lobe exhibiting abnormal metabolic activity, indicating an aggressive form of cancer.
  • A biopsy confirmed the diagnosis of high-grade spindle cell sarcoma, but the patient passed away shortly after, limiting treatment options.
View Article and Find Full Text PDF

Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an imaging technique that has demonstrated high sensitivity and specificity in detecting prostate cancer and its metastasis, especially in the bones. This case describes a 60-year-old man who presented for increased prostate-specific antigen (PSA) level and underwent [Ga]gallium-PSMA-11 PET/CT imaging for better disease assessment. Ga-PSMA-11 PET/CT revealed numerous radiotracer-positive lesions in both prostate lobes with associated sclerotic lesions on L4 and L5, but only L5 showed increased radiotracer avidity raising the possibility of metastasis.

View Article and Find Full Text PDF

Purpose: The severity of surrounding adhesions, anomalous anatomy, and technical issues are the main factors that complicate cholecystectomy. This study focused on determining the types and frequency of laparoscopic anatomical variations found during laparoscopic cholecystectomy in our limited-resources condition and on defining the safe zone of dissection.

Methods: This prospective study was conducted at a single center in Aden, Yemen from 2012 to 2019.

View Article and Find Full Text PDF

This review focuses on the pivotal role of radiotracers in breast cancer imaging, emphasizing their importance in accurate detection, staging, and treatment monitoring. Radiotracers, labeled with radioactive isotopes, are integral to various nuclear imaging techniques, including positron emission tomography (PET) and positron emission mammography (PEM). The most widely used radiotracer in breast cancer imaging is F-fluorodeoxyglucose (F-FDG), which highlights areas of increased glucose metabolism, a hallmark of many cancer cells.

View Article and Find Full Text PDF
Article Synopsis
  • Fibroblast Activation Protein Inhibitor (FAPI) PET imaging is a new way to find problems with the pancreas, especially pancreatitis, more effectively than traditional methods.
  • A 52-year-old man with a history of cancer experienced stomach pain, leading doctors to use both FAPI and another type of scan called FDG PET to understand his condition better.
  • FAPI PET helped doctors tell the difference between pancreatic tumors and inflammation, showing how important this new imaging technique can be for accurate diagnosis.
View Article and Find Full Text PDF
Article Synopsis
  • A study compared different types of PET scans, focusing on a new scan called Ga-FAPI-46 to see how well it detects cancer compared to a regular scan called F-FDG.
  • Eleven patients with various cancers, like colon and breast cancer, were examined using different types of PET scans.
  • The results showed that Ga-FAPI-46 was better at finding cancer spread in areas like lymph nodes and bones compared to F-FDG.
View Article and Find Full Text PDF

In adults, 68 Ga-FAP inhibitor ( 68 Ga-FAPI) PET/CT outperforms 68 Ga-radiolabeled somatostatin analog peptides ( 68 Ga PET/CT) and 18 F-FDG PET/CT in detecting thyroid lesions. This is the case of a 13-year-old boy newly diagnosed with medullary thyroid cancer with high calcitonin level. 68 Ga PET/CT revealed the presence of only a primary thyroid lesion.

View Article and Find Full Text PDF

Late-onset Alzheimer's disease (AD) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the APOE locus. A rare APOE variant named Christchurch (APOEch) yielding a missense mutation from Arginine to Serine at amino acid 136, has been suggested to exert a protective effect in an individual carrying the most penetrant form of Familial AD (Paisa mutation in PSEN1 gene, E280A). We describe here a new set of induced pluripotent stem cell (iPSC) lines, where the Christchurch mutation (Ch) has been introduced by gene editing into the APOE locus of three isogenic iPSC lines carrying the more common APOE variants (APOE 2/2, APOE 3/3, and an APOE 4/4) in homozygosity.

View Article and Find Full Text PDF

Background: In developing and developed countries, the prevalence of overweight and obesity has grown. The college phase is a critical period during which healthy behaviors are learned through lifestyle and social environment. College students are prone to increased stress, negatively affecting their daily activities and academic performance.

View Article and Find Full Text PDF

The work environment of office workers has hazards. One of the hazards is nonergonomic conditions. Nonergonomic conditions increase musculoskeletal disorders (MSDs) risk and interfere with work productivity.

View Article and Find Full Text PDF

Objective: Severe congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a promising repair technique with acceptable durability. However, most understanding of the procedure is empirical and retrospective.

View Article and Find Full Text PDF

Tenosynovial giant cell tumors represent a group of typically non-malignant tumors found within the joints and soft tissues. The occurrence of tenosynovial giant cell tumor alongside hematologic malignancies is an infrequent finding. Herein, we report a patient who presented with coinciding Hodgkin Lymphoma (HL) and tenosynovial giant cell tumor before chemotherapy initiation.

View Article and Find Full Text PDF

Macrophages play major roles in the pathophysiology of various neurological disorders, being involved in seemingly opposing processes such as lesion progression and resolution. Yet, the molecular mechanisms that drive their harmful and benign effector functions remain poorly understood. Here, we demonstrate that extracellular vesicles (EVs) secreted by repair-associated macrophages (RAMs) enhance remyelination ex vivo and in vivo by promoting the differentiation of oligodendrocyte precursor cells (OPCs).

View Article and Find Full Text PDF

Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has garnered significant attention in the context of neurotrauma research. Neuroproteomics involves the quantitative and qualitative analysis of nervous system components, essential for understanding the dynamic events involved in the vast areas of neuroscience, including, but not limited to, neuropsychiatric disorders, neurodegenerative disorders, mental illness, traumatic brain injury, chronic traumatic encephalopathy, and other neurodegenerative diseases. With advancements in mass spectrometry coupled with bioinformatics and systems biology, neuroproteomics has led to the development of innovative techniques such as microproteomics, single-cell proteomics, and imaging mass spectrometry, which have significantly impacted neuronal biomarker research.

View Article and Find Full Text PDF

Atherosclerosis (ATH) is a chronic cardiovascular disease characterized by plaque formation in arteries, and it is a major cause of illness and death. Although therapeutic advances have significantly improved the prognosis of ATH, missing therapeutic targets pose a significant residual threat. This research used a systems biology approach to identify the molecular biomarkers involved in the onset and progression of ATH, analysing microarray gene expression datasets from ATH and tissues impacted by risk factors such as high cholesterol, adipose tissue, smoking, obesity, sedentary lifestyle, stress, alcohol consumption, hypertension, hyperlipidaemia, high fat, diabetes to find the differentially expressed genes (DEGs).

View Article and Find Full Text PDF
Article Synopsis
  • A gallbladder torsion, or volvulus, can mimic other acute abdominal issues and may be misdiagnosed, especially in older patients.
  • An 80-year-old woman experienced severe pain in her abdomen, leading to the discovery of her gallbladder condition.
  • Timely surgical intervention (cholecystectomy) was successful, emphasizing the importance of recognizing this rare condition to prevent serious complications.
View Article and Find Full Text PDF