Publications by authors named "Haida Ding"
Article Synopsis
- Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne illness caused by the SFTS virus, which has been linked to neurological disorders, particularly in infected brain cells called microglia.
- The study found that SFTS virus infects microglial cells, activates the NLRP3 inflammasome, and leads to the secretion of interleukin 1β (IL-1β), which is associated with cell death and inflammation.
- Researchers identified that the viral protein NSs is crucial for activating the inflammasome, suggesting a potential mechanism through which SFTSV causes neurological damage and increases mortality risk in affected patients.
Viral infections are one of the leading causes in human mortality and disease. Broad-spectrum antiviral drugs are a powerful weapon against new and re-emerging viruses. However, viral resistance to existing broad-spectrum antivirals remains a challenge, which demands development of new broad-spectrum therapeutics.
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