Integrated analysis of air quality-vegetation-health effects of near-future air pollution control strategies.

To explore the effects of air pollution control strategies on air quality, vegetation, and health, we conducted an integrated modeling analysis for a representative industrial city, Zibo in the North China Plain, China. Two air pollution control scenarios for the near future (year 2026) are developed, including basic and strict control scenarios. The integrated modeling system based on Weather Research and Forecasting-Community Multiscale Air Quality Modeling (WRF-CMAQ) is utilized to analyze the effects of different scenarios on air quality improvement, vegetation, and health effects.

Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice.

Background And Objective: Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSCs) for the treatment of inflammatory bowel disease (IBD) and IBD-induced cancer. However, whether MSCs have the ability to suppress or promote tumor development remains controversial. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known to play a critical role in the homing of MSCs.

Retraction of: A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis.

Osteosarcoma is the most frequent primary bone tumor in children and adolescents. The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway is an attractive anticancer target because it plays key roles in the regulation of cell growth, division and differentiation. In this study, we demonstrated high expression of PI3K/mTOR signaling pathway-related genes in patients with osteosarcoma.