Publications by authors named "Haichao Zong"
Article Synopsis
- Depressive disorders are a significant global issue linked to inflammation, particularly increased after the COVID-19 pandemic, with the JAK-STAT signaling pathway not yet fully explored in this context.
- A recent analysis suggests that the JAK inhibitor tofacitinib may have potential beyond immune diseases by possibly preventing mood disorders.
- Research indicates that the JAK-STAT pathway is activated in depressive mouse models, leading to inflammation and synaptic issues, but tofacitinib shows promise in reversing these effects, highlighting its potential for treating depression.
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon is unclear. In our study, we found that anxiety induces a region-specific reduction in AMPK activity in the medial prefrontal cortex (mPFC). Concurrently, transgenic mice with brain-specific AMPK knockout displayed abnormal anxiety-like behaviors.
View Article and Find Full Text PDFUnderstanding GSH flux in developing neurons is prerequisite to reveal its role in neuronal development but necessiates an ultrasensitive assay. By systematically exploring key structural factors determing probe sensitivity in live cells, we developed a fluorogenic probe capable of imaging subtle GSH fluctuations in developing neurons.
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