Publications by authors named "Haichao Li"

Phyllotreta striolata is a major insect pest that threatens vegetable crops worldwide. Recently, its increasing resistance to chemical pesticides underscores the urgent need for novel control strategies. This study explores the potential of RNA biopesticides for managing P.

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Crystal structure prediction (CSP) represents a fundamental research frontier in computational materials science and chemistry, aiming to predict thermodynamically stable periodic structures from given chemical compositions. Traditional methods often face challenges such as high computational costs and local minima trapping. Recently, artificial intelligence methods, represented by generative adversarial networks (GANs), variational autoencoders (VAEs), diffusion models, and large language models (LLMs), have revolutionized the traditional prediction paradigm.

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Strong coupling between single qubits is crucial for quantum information science and quantum computation. However, it is still challenged, especially for single solid-state qubit. Here, we propose a hybrid quantum system, consisting of a coplanar waveguide (CPW) resonator weakly coupled to a single nitrogen-vacancy (NV) spin in diamond and an yttrium-iron-garnet (YIG) nanosphere holding Kerr magnons, to realize strong long-distance spin-spin coupling.

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The preparation of new-generation concrete from recycled coarse aggregate (RA) is an effective way to realize the resource utilization of construction waste. However, loose and porous attached mortar leads to RA showing low-density, high-water absorption, and high crushing value. However, carbonation modification treatment can effectively improve the performance of RA.

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Current methods for preparing single atom catalysts (SACs) often suffer from challenges such as high synthesis temperatures, complicated procedures, and expensive equipment. In this study, a facile and universal atomic diffusion strategy near Tamman temperature (AD-T) was proposed for the synthesis of semiconductor supported non-noble metal SACs, denoted as M/S, where M = Fe, Ni, Cu, Al and S = ZnO, CN, TiO(A), InO. Based on the empirical T (c.

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Cisplatin is one of the front-line therapeutic agents used to treat cancers, while drug resistance is a great obstacle to anti-tumor efficiency. Protein arginine methyltransferase 5 (PRMT5) has been identified as a promoter of tumorigenesis, motility, and invasion. Inhibiting PRMT5 reduced hypoxia-induced carboplatin resistance in lung adenocarcinoma (LUAD).

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Article Synopsis
  • Lignin nanoparticles (LNPs) are being recognized for their eco-friendly properties and potential in sustainable materials.
  • A new two-step fractionation technique has created four lignin fractions (F1, F2, F3, and F4) with optimal characteristics for LNPs production, achieving a high recovery rate of 88.7% from alkali lignin.
  • The study highlights how the size and structural properties of LNPs can be controlled for better antibacterial and antioxidant performance, particularly favoring a higher syringyl/guaiacyl ratio for smaller nanoparticles.
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Three-dimensional(3D) cell culture systems provide a larger space for cell proliferation, which is crucial for simulating cellular behavior and drug responses in the tumor microenvironment. In this study, we developed a novel 3D co-culture system for cell interactions, utilizing a commercialized bioreactor-microcarrier system. Mesenchymal stem cells (MSCs) were extracted via enzymatic digestion, and markers CD105 and CD31 were identified.

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OsMYB1 negatively mediates rice resistance to brown planthopper and rice blight. Additionally, OsMYB1 interacts with OsSPL14 and antagonizes its function by oppositely regulating downstream resistance-related genes. In their natural habitats, plants are concurrently attacked by different biotic factors.

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Technical alkaline lignin (TAL)-based composite films have been developed for anti-corrosion applications, during which one-component solvents, including acetone and ethanol, were employed. The poor solubility of TAL in the abovementioned solvents undoubtedly resulted in inhomogeneous surface micromorphology and the consequent unstable performance. The present study provides a series of ethylcellulose/TAL (EC/TAL) composite films with uniform surface microstructure by using the 1,4-dioxane/water binary solvent.

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The increasing incidence and mortality associated with lung cancer (LC) is a significant global health challenge. The underlying mechanisms contributing to LC remain inadequately understood. However, emerging evidence suggests that the epigenetic modifier protein arginine methyltransferase 5 (PRMT5) plays a complex role in various cellular processes, including DNA repair, gene transcription, and alternative splicing, through its function in catalyzing the symmetric dimethylation of both histone and non-histone proteins.

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Indomethacin (INDO) is a synthetic non-steroidal antipyretic, analgesic, and anti-inflammatory drug that commonly exists in both amorphous and crystalline states. Its amorphous state (A-INDO) is utilized by pharmaceutical companies as an active pharmaceutical ingredient (API) in the production of INDO drugs due to its higher apparent solubility and bioavailability. The crystal state also encompasses various crystal forms such as the α-crystal form (α-INDO) and γ-crystal form (γ-INDO), with the highly crystalline and insoluble γ-INDO being commercially available.

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The ability to isolate a quantum system from its environment is of fundamental interest and importance in optical quantum science and technology. Here we propose an experimentally feasible scheme for beating environment-induced dissipation in an open two-level system coupled to a parametrically driven cavity. The mechanism relies on a novel, to the best of our knowledge, cooperation between light-matter coupling enhancement and frequent measurements.

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Article Synopsis
  • Crystal Structure Prediction (CSP) is crucial for material design, and a new model called GAN-DDLSF uses a generative adversarial network to enhance prediction accuracy by combining real crystal data with a Gaussian distribution.
  • The model introduces a sampling method, data-driven latent space fusion (DDLSF), to overcome issues like "mode collapse" in traditional GANs, specifically tailored for binary crystal structures like gallium nitride (GaN).
  • Results show that GAN-DDLSF can generate over 9,300 GaN structures, with a significant portion being stable or metastable, indicating its potential to greatly improve the accuracy and efficiency of predicting various material structures.
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Brown planthopper (BPH) is the most destructive insect pest of rice. Drought is the most detrimental environmental stress. BPH infestation causes adaxial leaf-rolling and bulliform cells (BCs) shrinkage similar to drought.

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Carbon nanomaterials are widely used in many fields due to their unique properties. However, the novel production of carbon nanostructures is still a research challenge. Here, the self-assembly system of the anion surfactant sodium cocoylonate (SC)@NaCl has successfully produced a cube-shaped carbon nanoframework.

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Background: A combination of prone positioning (PP) and venovenous extracorporeal membrane oxygenation (VV-ECMO) is safe, feasible, and associated with potentially improved survival for severe acute respiratory distress syndrome (ARDS). However, whether ARDS patients, especially non-COVID-19 patients, placed in PP before VV-ECMO should continue PP after a VV-ECMO connection is unknown. This study aimed to test the hypothesis that early use of PP during VV-ECMO could increase the proportion of patients successfully weaned from ECMO support in severe ARDS patients who received PP before ECMO.

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Background: Compared with (HIV) patients, non-HIV patients with pneumonia (PCP) have more rapid onset, more rapid progression, and higher mortality.

Objectives: To investigate the predictive value of variables obtained upon hospital admission for in-hospital death and 90-day outcomes in non-HIV-PCP patients with respiratory failure (RF).

Methods: This was a single center retrospective study in a tertiary care institution over 15 years.

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Article Synopsis
  • Phenotypic plasticity allows organisms to adapt their physical traits without changing their genetics, helping them survive in variable environments.
  • This study focused on a type of marine ciliate, Glauconema spp., to understand how they change their traits based on food availability, revealing important genetic information linked to these adaptations.
  • Findings suggest that natural selection helps maintain phenotypic plasticity over time, providing new insights into how unicellular organisms evolve and adapt.
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Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive form of cancer with a low survival rate. A successful treatment strategy should not be limited to targeting cancer cells alone, but should adopt a more comprehensive approach, taking into account other influential factors. These include the extracellular matrix (ECM) and immune microenvironment, both of which are integral components of the tumor microenvironment.

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Microorganisms play a central role in sustaining soil ecosystems and agriculture, and these functions are usually associated with their complex life history. Yet, the regulation and evolution of life history have remained enigmatic and poorly understood, especially in protozoa, the third most abundant group of organisms in the soil. Here, we explore the life history of a cosmopolitan species-.

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Objective: to analyse the differences in malnutrition assessment between the Global Leadership Initiative on Malnutrition (GLIM) criteria and the Patient-Generated Subjective Global Assessment (PG-SGA) among patients with hepatobiliary and pancreatic malignancies. Method: this study was a cross-sectional study and included 126 hospitalised patients who underwent surgery for hepatobiliary and pancreatic malignancies between November 1, 2019 and August 1, 2020. The patients' clinical data were collected, and malnutrition assessments were completed using the different nutritional assessment tools.

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A novel high depth-to-width ratio of 15:1 narrow-gap gas metal arc welding technique was developed for the welding of S500Q steel in a horizontal butt joint. The bead arrangement of the I groove was optimized to produce a high-quality connection with the upper sidewall of the joint. The microstructure and mechanical properties were observed and evaluated by optical microscopy, scanning electron microscopy, tensile testing, and micro-hardness and impact toughness testing at 1/5, 2/5, 3/5, and 4/5 thickness of the joint.

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Glioblastoma (GBM), the most aggressive and fatal brain malignancy, is largely driven by a subset of tumor cells known as cancer stem cells (CSCs). CSCs possess stem cell-like properties, including self-renewal, proliferation, and differentiation, making them pivotal for tumor initiation, invasion, metastasis, and overall tumor progression. The regulation of CSCs is primarily controlled by transcription factors (TFs) which regulate the expressions of genes involved in maintaining stemness and directing differentiation.

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Article Synopsis
  • Cauliflower is a nutrient-rich vegetable whose genetic foundation for breeding hasn't been fully explored until now.
  • A high-quality genome assembly and a variation map of 971 cauliflower accessions were created to study its domestication process, tracing its evolution from broccoli.
  • Key findings include the identification of three important genes involved in curd formation and nine loci associated with its traits, providing insights into genetic factors affecting cauliflower's growth and development.
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