Publications by authors named "Haibo Yu"

The intricate nature and varied forms of bladder urothelial carcinoma (BLCA) highlight the need for new indicators to define tumor prognosis. Disulfidptosis, a novel form of cell death, is closely linked to BLCA progression, prognosis, and treatment outcomes. Our current goal is to develop a novel disulfidptosis-related immune prognostic model to enhance BLCA treatment strategies.

View Article and Find Full Text PDF

Background: This study aims to introduce the concept of habitat subregions and construct an accurate prediction model by analyzing refined medical images, to predict lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (ICC) before surgery, and to provide personalized support for clinical decision-making.

Methods: Clinical, radiological, and pathological data from ICC patients were retrospectively collected. Using information from the arterial and venous phases of multisequence CT images, tumor habitat subregions were delineated through the K-means clustering algorithm.

View Article and Find Full Text PDF

Current evidence indicates that circRNAs are involved in the development of multiple malignancies including hepatocellular carcinoma (HCC). However, the specific functions of circRNAs in HCC metabolism and progression and their underlying regulatory mechanisms remain unclear. We have identified a novel circRNA circMFN2, by bioinformatics analysis of circRNA microarray data from the GEO database.

View Article and Find Full Text PDF

Background: Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact with histone demethylases to regulate gene expression through histone methylation. However, the mechanisms underlying GDH1-mediated glutamine metabolism reprogramming and the roles of key metabolites during HBV infection remain unclear.

View Article and Find Full Text PDF

The disruption of transactive response DNA binding protein 43 kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of TDP-43 in ischemic stroke. Adult male C57BL/6 J mice were subjected to 30 or 60 min of transient middle cerebral artery occlusion (tMCAO), and examined at 1, 6, and 24 h post reperfusion.

View Article and Find Full Text PDF

The present study aimed to investigate the cardioprotective effects of acteoside (AC) on myocardial ischemia‑reperfusion injury (MIRI). To meet this aim, a network pharmacological analysis was conducted to search for key genes and signaling pathways associated with AC and MIRI. The infarct size of the rat heart was evaluated using 2,3,5‑triphenyltetrazolium chloride staining, and the serum levels of creatine kinase MB isoenzyme, cardiac troponin I, malondialdehyde and superoxide dismutase were subsequently detected in an experiment.

View Article and Find Full Text PDF

A novel class of 7-phenyl-[1,2,4]triazol-5(4H)-one derivatives was designed and synthesized, and their in vivo anticonvulsant activities were evaluated using subcutaneous pentylenetetrazole (Sc-PTZ) and maximal electroshock (MES) tests. Compounds 3u, 4f and 4k exhibited significant anticonvulsant activities in the Sc-PTZ model with ED values of 23.7, 17.

View Article and Find Full Text PDF

Background: The evidence in the primary prevention of sudden cardiac death (SCD) by using implantable cardioverter defibrillators (ICD) in patients with ischemic cardiomyopathy (ICM) is well-established but remains controversial for those with nonischemic cardiomyopathy (NICM). This study evaluates whether prognostic differences exist between ICM and NICM patients after ICD implantation.

Methods: Patients initially undergoing ICD implantation as primary SCD prevention were retrospectively enrolled from January 2017 to May 2023.

View Article and Find Full Text PDF

Background: Subcortical vascular mild cognitive impairment (svMCI) frequently occurs alongside depression symptoms, significantly affecting patients' quality of life. While cognitive decline and depression symptoms are linked to cerebellar changes, the specific relationship between these changes and cognitive status in svMCI patients with depression symptoms remains unclear.

Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms.

View Article and Find Full Text PDF

Background: Artificial intelligence (AI) has been widely adopted for the prediction of latent shock occurrence in critically ill patients in intensive care units (ICUs). However, the usefulness of an ICU-based model to predict latent shock risk in an emergency department (ED) setting remains unclear. This study aimed to develop an AI model to predict latent shock risk in patients admitted to EDs.

View Article and Find Full Text PDF

The GD-1 stellar stream exhibits spur and gap structures that may result from a close encounter with a dense substructure. When interpreted as a dark matter subhalo, the perturber is denser than predicted in the standard cold dark matter (CDM) model. In self-interacting dark matter (SIDM), however, a halo could evolve into a phase of gravothermal collapse, resulting in a higher central density than its CDM counterpart.

View Article and Find Full Text PDF

Introduction: , , , and are the primary pathogens responsible for gastrointestinal diseases in pigs, posing a significant threat to the health and productivity of pig production systems. Pathogen detection is a crucial tool for monitoring and managing these infections.

Methods: We designed primers and probes targeting the gene of , the 23S gene of , the gene of , and the gene of .

View Article and Find Full Text PDF
Article Synopsis
  • This study explores the effectiveness and safety of a new nano-drug delivery system using mesoporous silica to deliver gemcitabine (GEM) for pancreatic cancer treatment.
  • Conducted at Wenzhou Central Hospital from July 2022 to November 2023, the research involved creating and testing nanoparticles for their structure, drug loading capacity, release rates, and effects on cancer cells.
  • Results showed the nanoparticles effectively targeted pancreatic cancer cells, demonstrating promising drug delivery characteristics and cytotoxic effects, suggesting their potential as a novel treatment option.
View Article and Find Full Text PDF

Despite the success and widespread use of QM/MM methods in modeling (bio)chemically important processes, their accuracy is still not well understood. A key reason is because these methods are ultimately approximations to direct QM calculations of very large systems, which are impractical to perform in most cases. We highlight recent progress toward the development of realistic model systems where it is possible to obtain full QM reference data to directly and systematically evaluate the effectiveness of different QM/MM generation schemes.

View Article and Find Full Text PDF

In this editorial, we comment on an article by Xu . This article describes a case of crawling-type gastric adenocarcinoma (CRA) distinguished by its rare occurrence and diagnostic complexity. We reviewed the detailed case-report findings showcasing clinical, pathological, and molecular characteristics of CRA that shed light on its elusive nature and challenges for early detection and treatment.

View Article and Find Full Text PDF

Dynamic structural colors can change in response to different environmental stimuli. This ability remains effective even when the size of the species responsible for the structural color is reduced to a few micrometers, providing a promising sensing mechanism for solving microenvironmental sensing problems in micro-robotics and microfluidics. However, the lack of dynamic structural colors that can encode rapidly, easily integrate, and accurately reflect changes in physical quantities hinders their use in microscale sensing applications.

View Article and Find Full Text PDF

Adenosquamous carcinoma (ASC) of the duodenum is a malignant tumor that combines adenocarcinoma and squamous cell carcinoma components. Case reports of ASC are rare, and our understanding of the complex clinicopathological features and treatment strategies for the disease remains incomplete. The current study presents a case of duodenal ASC and discusses the available literature on this rare condition.

View Article and Find Full Text PDF
Article Synopsis
  • Hepatitis B virus (HBV) infection is a significant global health issue, and current antiviral treatments face challenges, making targeting the HBx protein a potential solution for developing new therapies.
  • A study utilized the Nano-Glo HiBiT Lysis Detection System to screen for herbal compounds that inhibit HBx, with asiatic acid from Centella asiatica showing promising results in reducing HBx levels and HBV activity in infected cells and mice.
  • Findings suggest that asiatic acid works by promoting HBx degradation through autophagy, leading to decreased HBV transcription and establishing it as a potential anti-HBV treatment.
View Article and Find Full Text PDF

Porcine respiratory disease is a significant economic problem for the global swine industry. (), (), and () are three important pathogenic bacteria of the swine respiratory tract. Notably, the three pathogens not only frequently manifest as mixed infections, but their striking clinical similarities also present difficulties for pig populations in terms of disease prevention and treatment.

View Article and Find Full Text PDF

Career crafting offers a new approach for individuals to cope with changing career situations. However, few studies have focused on personality-related antecedents that stably predict career proactivity. Additionally, as individuals' careers are embedded in various social relationships, career crafting involves significant social interaction.

View Article and Find Full Text PDF

Background: Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, with diagnoses mainly dependent on behavioral assessments.

Methods: In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 patients with depression symptoms (svMCI+D) and 16 patients without (svMCI-D), along with 34 normal controls (NC). The study used the fraction of the amplitude of low-frequency fluctuations (fALFF), resting-state functional connectivity, correlation analyses, and support vector machine (SVM) techniques.

View Article and Find Full Text PDF
Article Synopsis
  • Intrahepatic cholangiocellular carcinoma (ICC) is a common and aggressive liver cancer that often requires surgery, but many patients are diagnosed too late for surgical options.
  • A case study highlighted the successful treatment of an advanced ICC patient who could not initially undergo surgery due to vascular invasion; after 8 cycles of a combination of GEMOX chemotherapy, Tislelizumab immunotherapy, and Lenvatinib targeted therapy, significant tumor shrinkage and disappearance of vascular invasion occurred.
  • The patient ultimately had a successful radical surgical resection with complete pathological remission, suggesting that the GEMOX treatment combo offers a promising and safe potential for treating advanced ICC effectively.
View Article and Find Full Text PDF
Article Synopsis
  • Basement membranes (BMs) play a crucial role in the progression of cancer, particularly in hepatocellular carcinoma (HCC), leading researchers to focus on basement membrane-related genes (BMRGs) for potential therapeutic approaches.
  • A risk score model was created using six significant BMRGs identified from the TCGA HCC cohort, allowing researchers to predict clinical outcomes and tumor environments in HCC patients.
  • The study established a nomogram that combines the BMRGs score with other clinical factors, demonstrating its effectiveness in predicting survival rates and revealing that high BMRGs scores correlate with poorer overall survival and an immunosuppressive tumor microenvironment.
View Article and Find Full Text PDF

The synthesis of eleven new nickel Schiff base complexes each bearing four pendant groups is reported. The structures of the complexes differ in the identity of the pendant groups and/or diamine moiety. All complexes were characterised by microanalysis, Nuclear Magnetic Resonance (NMR) spectroscopy and Electrospray Ionisation Mass Spectrometry (ESI-MS), while the solid-state structures of two of the molecules were also determined using X-ray crystallographic methods.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionksaa3q9rsl2evmq9lqj78jpdh02q0nnp): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once