Biological Reinforced Concrete for Cartilage Repair With 3D Printing.

The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named "biological reinforced concrete" is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable "biorebars", while a hybrid biohydrogel acted as "biocement".

Attention-augmented multi-domain cooperative graph representation learning for molecular interaction prediction.

Accurate identification of molecular interactions is crucial for biological network analysis, which can provide valuable insights into fundamental regulatory mechanisms. Despite considerable progress driven by computational advancements, existing methods often rely on task-specific prior knowledge or inherent structural properties of molecules, which limits their generalizability and applicability. Recently, graph-based methods have emerged as a promising approach for predicting links in molecular networks.

Evaluating the efficacy of basiliximab versus no induction in low-immunological-risk kidney transplant recipients: a propensity score matched analysis.

Background: The optimal use of induction therapy in low-immunological-risk kidney transplant recipients (KTRs) remains uncertain. While Basiliximab (BSX) is widely utilized, its comparative outcomes with no induction therapy require further evaluation.

Method: This single-center retrospective cohort study included 182 low-immunological-risk KTRs who underwent transplantation between January 2022 and March 2023.

Association of residential green space with risk of sarcopenia and the role of air pollution: Evidence from UK Biobank.

This study aims to explore the association between residential green space exposure and sarcopenia, and the role of air pollutants in the association. This study utilized data from the UK Biobank. Residential green space and natural environment were assessed by the percentage of land covered by greenness within 300 m and 1000 m buffers.

PmiProPred: A novel method towards plant miRNA promoter prediction based on CNN-Transformer network and convolutional block attention mechanism.

It is crucial to understand the transcription mechanisms of miRNAs, especially considering the presence of peptides encoded by miRNAs. Since promoters function as the switch for gene transcription, precisely identifying these regions is essential for fully annotating miRNA transcripts. Nonetheless, existing computational methods still have room for improvement in the characterization of promoter regions.

Insights into the Spectral Characteristics and Sources of Dissolved Organic Matter in a Water Supply Reservoir.

This study focuses on the composition and sources of dissolved organic matter (DOM) in the Fancun Reservoir, located in Ningguo City, Anhui Province, China. The investigation was conducted by analyzing the spectral characteristics of DOM using UV-Vis absorption spectra and fluorescence spectroscopy. The humic substances were dominated by fulvic acid, with an average DOM concentration of 30.

Rapid and Large-Scale Synthesis of Chiral and Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring.

The large-scale preparation of fluorescent nanomaterials with laboratory-relevant chemical and optical properties will greatly forward their consumer market applications; however, it still remains challenging. In this work, a universal strategy was developed for the rapid and large-scale synthesis of fluorescent sulfur quantum dots that recently has drawn great attention because of their unique optical characteristics. From the fact that empty 3d orbitals of sulfide species are able to bind with lone-pair π electrons of the heteroatomic groups, many amino-group containing compounds, such as amino acid and polyethylenimine molecules, were exploited to synthesize sulfur quantum dots.

Network meta-analysis of pharmacological treatment for antibody-mediated rejection after organ transplantation.

Objective: This study aims to assess the efficacy of pharmacological interventions in mitigating graft injury in transplant patients with antibody-mediated rejection (AMR) through a network meta-analysis (NMA).

Methods: A search was conducted on databases such as Cochrane Library, PubMed, EmBase, and Web of Science for randomized controlled trials (RCTs) on pharmacological interventions for alleviating graft injury following AMR. The search was performed for publications up to April 12, 2024.

Childhood Exposure to Interparental Physical Violence and Adult Cardiovascular Disease.

Importance: Childhood adverse experiences have been linked with long-term risk of cardiovascular disease (CVD), yet the transgenerational associations between interparental behaviors and CVD remain poorly understood.

Objectives: To explore the association between exposure to childhood interparental physical violence and the subsequent risk of CVD and to examine whether the association is modified by adult depressive symptoms.

Design, Setting, And Participants: This population-based cohort study included data from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing study recruiting individuals aged 45 years or older, dated between June 1, 2011, and December 31, 2020, with a follow-up duration of 9 years.

Eco-friendly and facile one-step synthesis of manganese perovskite (TMPEA)MnBr for high performance X-ray imaging.

Inorganic-organic metal halogen perovskites, especially eco-friendly perovskites, have been intensively developed for X-ray imaging due to the high sensitivity, the low detection limit, and the high light yield. In this work, we successfully synthesized eco-friendly perovskite trimethylphenylammonium manganese(ii) bromide ((TMPEA)MnBr) with a facile one-step method at room temperature and demonstrated its impressive potential for X-ray imaging. As-synthesized (TMPEA)MnBr films have exhibited a high photoluminescence quantum yield (PLQY) of 83.

Enhancing hydride formation and transfer for catalytic hydrogenation via electron-deficient single-atom silver.

Metal hydrides are sensitive to HO and O, which reduces the atom efficiency of the hydride donors. Silver (Ag) is an inexpensive coinage metal; however, its lower activity compared to gold, platinum, and palladium limits its application in catalytic hydrogenation. Here, electron-deficient metallic single-atom Ag (AgSA) was loaded onto γ-AlO using a benzoquinone- and KNO- assisted photolysis approach.

Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study.

Background: Breast cancer, which is the most prevalent form of cancer among women globally, encompasses various subtypes that demand distinct treatment approaches. The tumor microenvironment and immune response are of crucial significance in the development and progression of breast cancer. Nevertheless, there has been scant evidence concerning the genes within breast cancer - specific immune cells.

Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer's disease: a summary data-based Mendelian randomization study.

Background: There is a growing body of evidence indicating the significant role of the immune system and immune cells in the progression of Alzheimer's disease (AD). However, the exact role of genes from various immune cell types in AD remains unclear. We aimed to utilize summary data-based Mendelian randomization (SMR) to explore the potential causal relationships between genes in specific immune cells and the risk of AD.

Glutamate dehydrogenase 1-catalytic glutaminolysis feedback activates EGFR/PI3K/AKT pathway and reprograms glioblastoma metabolism.

Background: Glutamine is an important nutrient for cancer cell growth that provides biological sources for nucleic acid and fatty acid synthesis, but the role of glutaminolysis in signal transduction and glioblastoma (GBM) progression remains little known.

Methods: Knockdown and overexpression cells were obtained to explore the functional roles of glutamate dehydrogenase 1 (GDH1) in cell proliferation, tumor formation, and aerobic glycolysis. RNA-seq, Chromatin immunoprecipitation, luciferase assay, and western blot were performed to verify the regulation of the EGFR-AKT pathway by the GDH1 (also known as GLUD1) and KDM6A.

misORFPred: A Novel Method to Mine Translatable sORFs in Plant Pri-miRNAs Using Enhanced Scalable k-mer and Dynamic Ensemble Voting Strategy.

The primary microRNAs (pri-miRNAs) have been observed to contain translatable small open reading frames (sORFs) that can encode peptides as an independent element. Relevant studies have proven that those of sORFs are of significance in regulating the expression of biological traits. The existing methods for predicting the coding potential of sORFs frequently overlook this data or categorize them as negative samples, impeding the identification of additional translatable sORFs in pri-miRNAs.

Associations between end stage renal disease and HLA polymorphisms in the Guangxi Zhuang population.

To investigate the genetic relationship between end stage renal disease (ESRD) and human leukocyte antigen (HLA) alleles in the Guangxi Zhuang population. We performed polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO) in 325 patients with ESRD and genotyped the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci. The direct counting method was used to determine the frequencies of HLA alleles, and Arlequin software (version 3.

Energy metabolism-related GLUD1 contributes to favorable clinical outcomes of IDH-mutant glioma.

Background: Glioma is the most common brain tumor. IDH mutations occur frequently in glioma, indicating a more favorable prognosis. We aimed to explore energy metabolism-related genes in glioma to promote the research and treatment.

PEAI Surface Treatment for Low Ion Migration and High-Performance FAPbBr Single-Crystal X-ray Detectors.

Organometal halide perovskite single crystals (SCs) are the most promising candidates for the next generation of radiation detection materials. However, surface defects severely affect their detection performance and limit further applications. Here, we identified the surface defect types of FAPbBr SCs and employed phenethylammonium iodide (PEAI) solution to treat the crystal surface and to investigate their effects on ion migration, photoelectric performance, and X-ray detection performance.

Inhibition of the ITGB1 gene attenuates crystalline silica-induced pulmonary fibrosis via epithelial-mesenchymal transformation.

Silicosis is a systemic disease caused by long-term exposure to high concentrations of free silica dust particles in the workplace. It is characterized by a persistent inflammatory response, fibroblast proliferation, and excessive collagen deposition, leading to pulmonary interstitial fibrosis. Epithelial interstitial transformation (EMT) can cause epithelial cells to lose their tight junctions, cell polarity, and epithelial properties, thereby enhancing the properties of interstitial cells, which can lead to the progression of fibrosis and the formation of scar tissue.