Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge.

We previously generated a panel of human monoclonal antibodies (mAbs) against Zika virus (ZIKV) and identified one, ZIKV-116, that shares germline usage with mAbs identified in multiple donors. Here we show that ZIKV-116 interferes with ZIKV infection at a post-cellular attachment step by blocking viral fusion with host membranes. ZIKV-116 recognizes the lateral ridge of envelope protein domain III, with one critical residue varying between the Asian and African strains responsible for differential binding affinity and neutralization potency (E393D).

Determination of the geographical origin of maize (Zea mays L.) using mineral element fingerprints.

Background: Maize (Zea mays L.) is a staple cereal crop and feed crop throughout the world. In this article, a mineral element fingerprinting technique was applied to single out suitable element indicators to determine the geographical origin of maize.

miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1.

Endothelial-mesenchymal transition (EndMT) is a frequent event in endothelial dysfunction, which is associated with pulmonary arterial hypertension (PAH). MiR-181 family members exert diverse effects in multiple biological processes. However, the relationships between miR-181b-5p (miR-181b) and EndMT in PAH are not well understood.

Synthesis, characterization and bioactivities of a new covalent copper(II) compound derived from {PMoO} and thiosemicarbazones.

In this article, a new compound H[{Cu(HL)(HO)}(PMoO)]·5HO (1) (HL = 2-acetylpyrazine thiosemicarbazone) has been synthesized and structurally characterized by single-crystal X-ray diffraction of and other detection techniques. Interestingly, the structure of 1 is different from many reported copper-based complexes, in which the [PMoO], two Cu ions and two HL were directly connected by covalent bands. Biological studies demonstrated that 1 indicated moderate antibacterial activity against Escherichia coli (E.

miR-181a/b-5p ameliorates inflammatory response in monocrotaline-induced pulmonary arterial hypertension by targeting endocan.

Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by vascular remodeling, endothelial cell (EC) dysfunction, and inflammation. The roles of microRNAs have received much critical attention. Thus, this study was attempted to show the biological function of miR-181a/b-5p (miR-181a/b) in monocrotaline (MCT)-induced PAH.

Maize NAC-domain retained splice variants act as dominant negatives to interfere with the full-length NAC counterparts.

The plant-specific NAC transcription factors play diverse roles in various stress signaling. Alternative splicing is particularly prevalent in plants under stress. However, the investigation of cadmium (Cd) on the differential expression of the splice variants of NACs is in its infancy.

Transcriptome-wide identification of indole glucosinolate dependent flg22-response genes in Arabidopsis.

Indole glucosinolates are known to play essential and diverse roles in Arabidopsis immunity to pathogens. However, a complete understanding of the function of these compounds in plant immunity remains unclear. In this study, we investigated the transcriptome profile in loss-of-function mutant of MYB51, the key transcription factor that controls the biosynthesis of indole glucosinolates.

Effect of morphine added to multimodal cocktail on infiltration analgesia in total knee arthroplasty: A meta-analysis of randomized controlled trials.

Background: The local injection of multimodal cocktail is currently commonly used in the treatment of postoperative pain after total knee arthroplasty (TKA). It is still inconclusive whether the morphine added to the intraoperative injection mixture could make some difference. This meta-analysis aimed to evaluate the efficacy and safety of additional morphine injection on postoperative analgesia in TKA, and provide some useful information on morphine usage in clinical practice.

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.

The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp) or prM and the ectodomain of E protein (GAd-Eecto). Both vaccines induce humoral and cell-mediated immune responses and prevent lethality after ZIKV challenge in mice.

Dyes Adsorption Behavior of FeO Nanoparticles Functionalized Polyoxometalate Hybrid.

The magnetic adsorbent, FeO@[Ni(HL)]H[PMoO]·2HO (FeO@), is synthesized by employing the nanoparticles FeO and polyoxometalate hybrid . Zero-field-cooled (ZFC) and field-cooled (FC) curves show that the blocking temperature of FeO@ was at 120 K. Studies of FeO@ removing cationic and anionic dyes from water have been explored.

The suitability of rare earth elements for geographical traceability of tea leaves.

Background: Rare earth elements (REEs) have been used for the identification of the geographical origins of an increasing number of foods. This study analyzed the effects of geographical origin, harvest season, variety, and their interactions on REEs in tea leaves to investigate whether REEs were suitable for geographical identification of tea leaves. Tea leaves of different varieties and the corresponding soils were collected in different seasons from different areas of China.

The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency.

Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells (TRCs) isolated from three-dimensional fibrin gels enhances the MPs' drug-delivery efficiency. We found that, compared with MPs derived from tumour cells cultured in conventional tissue-culture plastic, TRC-derived MPs intravenously injected in tumour-xenograft-bearing mice showed enhanced accumulation in tumour tissues, enhanced blood-vessel crossing and penetration into tumour parenchyma, and preferential uptake by highly tumorigenic TRCs.

Effects of Total Hip Arthroplasty on Axial Alignment of the Lower Limb in Patients with Unilateral Developmental Hip Dysplasia (Crowe type IV).

Background: The aim of this study was to evaluate the influence of total hip arthroplasty on axial alignment of the lower limb in adults with unilateral developmental hip dysplasia (Crowe type IV).

Methods: We retrospectively reviewed medical records of 50 adults who underwent total hip arthroplasty, in which the acetabular cup was placed in the anatomical position. The following parameters were measured before surgery, immediately after surgery, and two years later: mechanical axis deviation (MAD), tibiofemoral angle (TFA), femoral offset, hip-knee-ankle angle (HKA), mechanical lateral distal femoral angle (LDFA), mechanical medial proximal tibial angle, height of medial femoral condyle, height of lateral femoral condyle, and leg lengthening.

Fabrication of highly sensitive and reproducible 3D surface-enhanced Raman spectroscopy substrates through in situ cleaning and layer-by-layer assembly of Au@Ag nanocube monolayer film.

A highly sensitive and uniform three-dimensional (3D) surface-enhanced Raman spectroscopy (SERS) substrate has been fabricated by in situ ultraviolet ozone cleaning and layer-by-layer self-assembly. The SERS properties and the structural changes of the substrates were systematically studied by adjusting the cleaning time upon the in situ and post cleaning strategy. Under the optimal cleaning condition, the cleaning technology could give rise to clean and optimal surfaces for SERS analysis, thus obtaining efficient plasmonic films populated with a large number of homogeneous 'hot-spots'.

Preparation of FeO@polyoxometalates Nanocomposites and Their Efficient Adsorption of Cationic Dyes from Aqueous Solution.

In this work, two magnetic adsorbents FeO@ and FeO@ were prepared by combining FeO nanoparticles and polyoxometalate hybrids [Ni(HL)]H[PMoO]·4HO (), [HL]H[PMoO]·12HO () (HL = 2-acetylpyridine-thiosemicarbazone). The temperature-dependent zero-field-cooled (ZFC) and field-cooled (FC) measurements indicated the blocking temperature at 160 K and 180 K, respectively. The Brunauer-Emmett-Teller (BET) surface area of FeO@ and FeO@ is 8.

ZnO/GaN Heterostructure as Ultraviolet Photodetector Fabricated by One-Step Aqueous Method.

ZnO thin films were fabricated on p-GaN substrate with zinc acetate as precursors by one-step aqueousmethod in this paper. The morphological and structural properties of ZnO/GaN heterostructure were studied. Meanwhile, the ultraviolet photodetector (UV) device based on ZnO/GaN heterostructure was fabricated and showed excellent UV response.

Enantioselective and site-specific copper-catalyzed reductive allyl-allyl cross-coupling of allenes.

A copper-catalyzed asymmetric reductive allyl-allyl cross-coupling reaction of allenes with allylic phosphates wherein allenes were used as allylmetal surrogates has been achieved for the first time. This protocol provides an efficient and straightforward route to optically active 1,5-dienes in a highly enantioselective and site-specific fashion. Furthermore, all-carbon quaternary stereogenic centers could also be constructed with this protocol.

Highly monodisperse Au@Ag nanospheres: synthesis by controlled etching route and size-dependent SERS performance of their surperlattices.

For accurate experimental and theoretical research, the preparation of nanocrystrals with regular morphology is of significant importance. In this work, we investigated a facile and effective route for generating highly spherical Au@Ag nanospheres (NSs) with tuneable size and uniform morphology at room temperature. The aqueous synthesis mainly involved seed-mediated growth method together with oxidation etching employing sodium hypochlorite (NaClO) as etching agent.

Correction: Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang.

The version of this article originally published was not open access. This article should have been open access. The error has been fixed, and the article is now open access.

The reduction effects of riparian reforestation on runoff and nutrient export based on AnnAGNPS model in a small typical watershed, China.

The continuous deterioration of the aquatic environment in rivers and streams is increasingly causing social and political tensions. To alleviate aquatic environmental problems, especially for the nonpoint source pollution, establishment of riparian forest buffers has been demonstrated as an effective control measure. However, few comprehensive studies of the reduction effects of riparian reforestation on the aquatic environment have been performed, particularly in identifying the suitable widths of reforestation projects.

Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang.

Essential hypertension (EH) is a principal contributing factor in worldwide cardiovascular disease mortality. Although interventions that minimize environmental risk factors for EH are associated with reduced cardiovascular disease, such approaches are limited for individuals with high genetic EH risk. In this study, we investigated possible associations between ACE2 polymorphisms and hypertension-related target organ damages in south Xinjiang, China.

Effect of premature birth on long-term systolic blood pressure variability in women.

Objective: To investigate the effect of premature birth (PTB) on long-term systolic blood pressure (SBP) variability (SBPV) in women.

Methods: A total of 1974 pregnant women were divided into PTB group and non-PTB (NPTB) group. The SBP standard deviation (SSD) was calculated by four annual SBP values measured in 2006-2007, 2008-2009, 2010-2011, and 2012-2013.

Endogenous Stimuli-Responsive Nucleus-Targeted Nanocarrier for Intracellular mRNA Imaging and Drug Delivery.

Drug resistance arising from overexpressed efflux transporters increases the efflux of drugs and accordingly restricts the efficacy of chemotherapy. Advances in nanocarriers have provided potential strategies to cope with drug resistance. Herein, endogenous stimuli-responsive nucleus-targeted nanocarrier is developed for intracellular multidrug resistance protein 1 (MRP1) mRNA imaging and drug delivery.