Publications by authors named "HaiMing Liu"
In this research, the Yuxi section of Central Yunnan Water Diversion Project in Southwest of China, including the tunnel and the traversed sandy dolomite along its route, was selected as the research area, and different sandification degrees classification, including strongly sandy, medium sandy, and weakly sandy, were collected. A comprehensive suite of geotechnical tests was conducted, which included CT scanning, cathodoluminescence, density, porosity, softening coefficient, saturation coefficient, point load test, and uniaxial compressive strength (UCS) test. The Point load index (I) model for predicting UCS of different sandification degrees dolomite under dry and saturated conditions were analyzed by least square regression, and the empirical equation with correlation coefficient (R) between 0.
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- * Traditional methods for assessing sandification of dolomite are often slow and inaccurate, necessitating improved techniques for better classification.
- * This study introduces a CNN-based image classification approach, utilizing a dataset of 5729 images of sandy dolomite, achieving a high accuracy rate of 91.4%, showcasing a significant advancement in the field.
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- * Research found that NSCLC patients with mutations had higher levels of circulating PD-L1-positive small extracellular vesicles (sEVs), which negatively affected CD8 T cell functionality in tumor tissues.
- * The study identified that both mutation-induced and TKI treatment-induced increases in PD-L1-positive sEVs occur through different molecular pathways (HRS and ALIX), potentially explaining the limited response to immunotherapy in these patients.
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- - The study investigates why some patients don’t benefit from PD-1/PD-L1 cancer therapies, focusing on the intrinsic roles of PD-L1 in head and neck squamous cell carcinoma (HNSCC) cells.
- - Using a CRISPR screen, researchers found that PD-L1-deficient cells rely on certain ferroptosis-related genes for survival and are more prone to cell death when ferroptosis is induced.
- - PD-L1 appears to protect HNSCC cells from ferroptosis by boosting the antioxidant SOD2, which keeps reactive oxygen species (ROS) levels low, suggesting that targeting PD-L1's functions could improve treatment outcomes.
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- Researchers wanted to find out if patients with a specific type of breast cancer benefit from getting radiation therapy after chemotherapy.
- They looked at data from 1,092 women who had breast cancer between 2010 and 2015 to see how radiation affected their survival rates.
- The study found that getting radiation after chemotherapy improved overall survival, but it didn't show a big difference in survival specifically from cancer; some groups did see more benefits than others.
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- * A study with 40 participants explored how different text speeds and movement types impacted cybersickness levels, revealing that factors like satiety, text speed, and movement mode are key contributors.
- * The findings indicated that higher cybersickness levels could hinder search abilities in AR, with font color being particularly influential and gender differences affecting cybersickness onset at lower levels.
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- Only a small number of cancer patients benefit from immune checkpoint blockade therapy due to complex interactions among immune checkpoint pathways and molecules in circulating small extracellular vesicles (sEVs).
- The study found that PD-1 and CD80 on immunocyte-derived sEVs lead to reduced PD-L1 on tumor cell membranes while increasing PD-L1 secretion, contributing to systemic immunosuppression and making tumors less responsive to immune attacks.
- Analyzing multiple checkpoint molecules on circulating sEVs can help differentiate between patients who will respond well to anti-PD-1 treatments and those who will not, highlighting a potential target for improving cancer therapies.
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- Sandy Dolomite is a common rock whose uniaxial compressive strength (UCS) is crucial in various engineering fields but is difficult to measure directly.
- This research introduces a new method using convolutional neural networks (CNN) and regression analysis (RA) to predict UCS more efficiently.
- Testing on 158 dolomite samples shows that CNN provides more accurate predictions than RA and is better at handling uncertainties in test results.
A Privacy-Preserving Approach to Effectively Utilize Distributed Data for Malaria Image Detection.
Bioengineering (Basel)
March 2024
Article Synopsis
- * The research proposes using federated learning (FL) to enhance collaborative machine learning without sharing sensitive medical data, utilizing models like ResNet-50 and DenseNet on a malaria dataset of 27,560 images.
- * Results indicate that DenseNet outperforms ResNet-50 in accuracy, achieving 75% compared to 72%, and highlights the benefits of FL in improving model performance while preserving data privacy and adhering to GDPR regulations.
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- - The study explores the impact of Dihydroartemisinin (DHA) on depression by examining its effects on gut microbiota and behavioral changes in mice subjected to chronic unpredictable mild stress (CUMS).
- - DHA treatment increased sugar water preference and reduced signs of despair in various behavioral tests, while also enhancing gut microbiota diversity and correcting imbalances caused by stress.
- - Analysis suggests that the interaction between DHA and gut microbiota may influence depression through pathways related to glucose metabolism and energy regulation, indicating DHA's potential as a therapeutic agent.
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- Researchers used various advanced techniques like X-ray diffraction and nuclear magnetic resonance to study a new crystalline structure called (i-PrNHMe)[CdBr].
- In this model, the (i-PrNHMe) cation is a flexible near-spherical rotator, while the {[CdBr]} polymer acts as a rigid stator.
- The connection between these two components is achieved through charge-assisted hydrogen bonds, enabling the unique rotor-stator mechanism.
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- Nature has evolved various biological systems with switchable recognition functions, like biological membranes that adjust ion selectivity based on external stimuli.
- A significant challenge in chemistry is creating artificial systems that can switch recognition of specific guests in response to changing environmental conditions.
- Researchers developed a temperature-responsive porous crystal that selectively adsorbs carbon monoxide (CO) at low temperatures and methane (CH) at higher temperatures, achieving high separation factors due to its unique diffusion-regulating mechanism.
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- DNMT inhibitors are commonly used in blood cancers, but their effectiveness in solid tumors like gastric cancer (GC) is limited due to low response rates and poor combination strategies.
- This study found that reducing DNMT1 levels in GC cells decreased their sensitivity to 5-Azacytidine, and that KRAS mutations or MEK/ERK activation can impact DNMT1 expression.
- The findings suggest that combining DNMT inhibitors with MEK/ERK inhibitors may offer a better treatment approach for gastric cancer, as DNMT1 levels correlate with RAS/MEK/ERK signaling pathways.
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- Oral squamous cell carcinoma (OSCC) is a common and aggressive type of head and neck cancer that often spreads to lymph nodes; this study focuses on the role of the Ras-related protein Rab-27A (RAB27A) in its progression.
- RAB27A was found to be overexpressed in OSCC tissues and metastatic lymph nodes, correlating with worse clinical outcomes and poorer survival rates; silencing this protein reduced cancer cell growth and spread in lab experiments.
- The research also linked RAB27A to the epidermal growth factor receptor (EGFR) signaling pathway, suggesting it could be a promising target for new treatments against OSCC.
Confinement of discrete coordination cages within nanoporous lattices is an intriguing strategy to gain unusual properties and functions. We demonstrate here that the confinement of coordination cages within metal-organic frameworks (MOFs) allows the spin state of the cages to be regulated through multilevel host-guest interactions. In particular, the confined in situ self-assembly of an anionic FeL nanocage within the mesoporous cationic framework of MIL-101 leads to the ionic MOF with an unusual hierarchical host-guest structure.
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- The study investigates the safety and effectiveness of using distal transradial access (dTRA) to treat radial artery occlusion (RAO) after transradial artery puncture.
- In this observational study, 28 patients with confirmed RAO underwent retrograde recanalization through dTRA, resulting in a 96.4% success rate for the procedure.
- Only one patient experienced a minor complication (forearm hematoma), indicating that dTRA is a safe method for addressing RAO with minimal risks.
Background: Lung cancer is prone to metastasize to the brain, which is difficult for surgery and leads to poor prognosis due to poor chemotherapy efficacy.
Objective: Our aim is to evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) for brain multi-metastases.
Methods: In the retrospective study, a total of 51 non-small cell lung cancer (NSCLC) patients with brain multi-metastases (3-5 metastases) receiving SBRT in the local hospital between 2016 and 2019 were enrolled for analyzing the efficacy and safety of SBRT.
Doping the boron (B) element endowed organic π-conjugated polymers (OCPs) with intriguing optoelectronic properties. Herein, we introduce a new series of thienylborane-pyridine () Lewis pairs via the facile reactions between thienylborane and various pyridine derivatives. Particularly, we developed a "one-pot" synthetic protocol to access with an unstable 4-bromopyridine moiety.
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- Liquid biopsy technology uses body fluid samples to analyze tumor markers, allowing for early cancer diagnosis and treatment evaluation in a minimally invasive manner.
- The paper presents a novel 3D magnetic chip (3DMC-system) designed for in vivo detection and real-time monitoring of circulating tumor cells (CTCs) using specialized magnetic nanospheres for better accuracy.
- This system not only improves the detection of CTCs at early tumor stages but also has the potential to integrate treatment options, offering a personalized medical approach for cancer patients.
Unlabelled: It has long been known that abundant symbiotic bacteria exist in the tunic and gut of marine ascidians, and that these play crucial roles in host development, physiological metabolism, and environmental adaptation. However, the identity, roles and functions of these symbiotic bacteria are known for only a few strains. In this study, we isolated and cultivated 263 strains of microorganisms from the intestine of the marine ascidian through a combination of aerobic and anaerobic culture approaches.
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- A 38-year-old man was diagnosed with an acute heart attack in April 2021 and underwent a procedure to open a blocked artery using a technique that accessed the radial artery in his wrist.
- By September 2021, he still experienced chest pain, leading to a second procedure where doctors discovered his radial artery was blocked.
- They used a specialized balloon to treat the blockage, and after 24 hours, his arterial pulsation returned to normal, with successful follow-ups showing no complications over 14 months.
Extracellular vesicles (EVs) are cell-derived membrane-enclosed structures that deliver biomolecules for intercellular communication. Developing visualization methods to elucidate the spatiotemporal dynamics of EVs' behaviors will facilitate their understanding and translation. With a quantum dot (QD) labeling strategy, a single particle tracking (SPT) platform is proposed here for dissecting the dynamic behaviors of EVs.
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- The increasing use of orthopedic implants is at risk due to bacterial infections, biofilms, and antibiotic resistance, creating a need for improved anti-infective materials.
- Researchers have developed a new strategy using biodegradable pure zinc (Zn) to enhance neutrophil extracellular traps (NETs), which can effectively eliminate bacteria around implants.
- The study found that Zn promotes NETs formation and boosts the bactericidal response in neutrophils, which was confirmed in an animal model, offering hope for developing advanced antibacterial biomaterials for treating orthopedic infections.
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- Rapid urbanization in China has led to unbalanced regional development, impacting economic growth and social stability.
- The research utilized data from 35 large and medium-sized cities between 2011 and 2020, applying both qualitative and quantitative methods to analyze social development disparities.
- Findings indicate that while social development levels improved overall, significant gaps remain, with eastern regions seeing a decrease in disparity while central and western regions face increasing gaps.