Publications by authors named "HaiMei Chen"

Objective: Oral cancer refers to a group of malignancies. The disease's complexity requires a multidisciplinary approach, encompassing oncology, dentistry, epidemiology, molecular biology, and other fields. Given this multifaceted nature, bibliometrics has emerged as a crucial tool to navigate the vast array of academic literature surrounding oral cancer.

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Background: Trachelospermum jasminoides has medicinal and ornamental value and is widely distributed in China. Although the chloroplast genome has been documented, the mitochondrial genome has not yet been studied.

Results: The mitochondrial genome of T.

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Article Synopsis
  • The text discusses a woody shrub belonging to the Asteraceae family and details its chloroplast genome, which is 152,934 base pairs long and consists of specific regions including large and small single-copy regions as well as inverted repeats.
  • It identifies 114 unique genes within this chloroplast genome, including 80 protein-coding genes, four rRNA genes, and 30 tRNA genes.
  • Phylogenetic analysis shows that this shrub is closely related to other plants in the Vernonieae tribe, and this study marks the first report of its chloroplast genome, adding valuable genomic data for its genus.
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Panax quinquefolius is a perennial plant with medicinal values. In this study, we assembled the complete mitochondrial genome (mitogenome) of P. quinquefolius using PMAT assembler.

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Roxb. ex Ait. 1812 belongs to the Phaseoleae tribe within the Fabaceae family and has significant pharmaceutical value.

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is an economically significant medicinal plant. Yet, the structure and sequence of its mitochondrial genome has not been published, which plays a crucial role in evolutionary analysis and regulating respiratory-related macromolecule synthesis. In this study, the mitogenome was sequenced employing a combination of Illumina short reads and Nanopore long reads, with subsequent assembly using a hybrid strategy.

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Hemsl. 1888, native to Hong Kong, belongs to the subgenus Syncarpea within the genus of the family. The complete chloroplast genome of spans 156,954 bp, comprising four subregions: a large single-copy region (86,290 bp), a small single-copy region (18,394 bp), and a pair of inverted repeats (26,135 bp).

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In oncology, clinical decision-making relies on a multitude of data modalities, including histopathological, radiological, and clinical factors. Despite the emergence of computer-aided multimodal decision-making systems for predicting hepatocellular carcinoma (HCC) recurrence post-hepatectomy, existing models often employ simplistic feature-level concatenation, leading to redundancy and suboptimal performance. Moreover, these models frequently lack effective integration with clinically relevant data and encounter challenges in integrating diverse scales and dimensions, as well as incorporating the liver background, which holds clinical significance but has been previously overlooked.

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Article Synopsis
  • Tools for visualizing genomes are crucial for studying genomic features and interactions, but existing tools fall short for plant mitogenomes due to unique characteristics like non-linear exon arrangements and complex structures.
  • The newly developed PMGmap software uses Python to address these limitations by offering detailed visualizations of genes, including noncoding features and chromosomal architecture, effectively scaling genomic regions.
  • PMGmap outperformed existing tools in visualizing 405 plant mitogenomes, establishing itself as a valuable resource for researchers in the field, with access available online.
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Ardisia S.W. (Primulaceae), naturally distributed in tropical and subtropical regions, has edible and medicinal values and is prevalent in clinical and daily use in China.

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Objective: To investigate the genetic results of whole exome sequencing of bone marrow from new onset multiple myeloma (MM) patients to analyze the process of genetic clonal evolution in MM patients.

Methods: Genomic DNA was extracted from bone marrow samples of 15 MM patients and the whole exomes sequencing was performed using next generation sequencing technology. Using own buccal cells as germline controls, combinated with clinical information, the mutation profile of genes from high-risk asymptomatic myeloma to symptomatic myeloma were analyzed, and genes that may be associated with the efficacy and side effects of bortezomib were screened.

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Background: L. is one of the most important crops widely cultivated in 70 countries across Asia, Africa, and Latin America. Mitochondria are essential organelles that play critical roles in cellular respiration, metabolism, and differentiation.

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With its nearly 200 species, the genus is the most species-rich within the Cactaceae family, yet surprisingly, few of its chloroplast genomes have been studied. We focused on the species DC. 1828, a petite cactus native to Mexico and favored by horticulturists, yet whose phylogenetic relationships remain uncertain due to a lack of genomic data.

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In this study, we assembled the complete plastome and mitogenome of Caragana spinosa and explored the multiple configurations of the organelle genomes. Caragana spinosa belongs to the Papilionoidea subfamily and has significant pharmaceutical value. To explore the possible interaction between the organelle genomes, we assembled and analyzed the plastome and mitogenome of C.

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All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here we report a previously undescribed eukaryotic pathway for iron sensing in which molecular iron is required to sustain active histone demethylation and maintain the expression of critical components of the pro-anabolic mTORC1 pathway.

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Panax notoginseng is one of the most valuable medicinal species. However, its mitochondrial genome has not been reported yet. We aimed to determine the mitogenome sequence of P.

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Background It is unknown whether the additional information provided by multiparametric dual-energy CT (DECT) could improve the noninvasive diagnosis of the aggressive macrotrabecular-massive (MTM) subtype of hepatocellular carcinoma (HCC). Purpose To evaluate the diagnostic performance of dual-phase contrast-enhanced multiparametric DECT for predicting MTM HCC. Materials and Methods Patients with histopathologic examination-confirmed HCC who underwent contrast-enhanced DECT between June 2019 and June 2022 were retrospectively recruited from three independent centers (center 1, training and internal test data set; centers 2 and 3, external test data set).

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(Roxb.) Prain 1897, belonging to the family Fabaceae, is not only a landscape tree but also a medicinal plant. At present, few plastomes have been reported from , which delays the in-depth phylogenomic studies and the development of high-resolution discriminating markers for this genus.

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L. 1753 is a perennial herbaceous flowering plant, traditionally used in foods and medicines. In this study, we sequenced, assembled, and characterized the complete plastome of from Beijing, China.

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Background: Artemisia argyi L., also known as mugwort, is a perennial herb whose leaves are commonly used as a source of traditional medicines. However, the evolution and structure of the mitochondrial genome (mitogenome) in A.

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Our previous study was the first to confirm that the predominant conformation of mitochondrial genome (mitogenome) sequence of species contains two circular chromosomes. To further understand the organization, variation, and evolution of mitogenomes, we characterized the mitogenome of . The mitogenome of was sequenced using Illumina short reads and Nanopore long reads and assembled using a hybrid assembly strategy.

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Background: The plants of the genus Clerodendrum L. have great potential for development as an ornamental and important herbal resource. There is no significant morphological difference among many species of the genus Clerodendrum, which will lead to confusion among the herbs of this genus and ultimately affect the quality of the herbs.

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Chloroplast genomes have been widely used in studying plant phylogeny and evolution. Several chloroplast genome visualization tools have been developed to display the distribution of genes on the genome. However, these tools do not draw features, such as exons, introns, repetitive elements, and variable sites, disallowing in-depth examination of the genome structures.

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