Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.

Purpose: Medium-chained chlorinated paraffins (MCCPs) are a class of chlorinated derivatives of straight-chain n-alkanes with complex compositions, which are widely used in industry. The chlorinated paraffins (CPs) are divided into short chain chlorinated paraffins (SCCPs), medium chain chlorinated paraffins (MCCPs) and long chain chlorinated paraffins (LCCPs). SCCPs have been banned due to their severe bioaccumulation and biotoxicity.

The association of hypophysitis with immune checkpoint inhibitors use: Gaining insight through the FDA pharmacovigilance database.

The use of immune checkpoint inhibitor (ICI) marked a revolutionary change in cancer treatment and opened new avenues for cancer therapy, but ICI can also trigger immune-related adverse events (irAEs). Here, we investigated the publicly available US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to gain insight into the possible association between immune checkpoint inhibitors and hypophysitis. Data on adverse events (AEs) due to hypophysitisfor nivolumab, pembrolizumab, ipilimumab, and atezolizumab were collected from the US FDA Adverse Event Reporting System from the first quarter of 2004 to the second quarter of 2021, and the signals for hypophysitis associated with the four drugs were examined using the reporting odds ratio (ROR) method.

Self-Powered Colorful Dynamic Electrowetting Display Systems Based on Triboelectricity.

Electrowetting displays (EWDs) based on microfluidics are highly sought after in the fields of electronic devices, smart homes, and information communication. However, the power supply of the EWD systems for visually engaging multi-color displays remains a big challenge. Herein, self-powered colorful dynamic display systems are developed by integrating the triboelectric nanogenerator (TENG) with the EWD device.

Clinical Manifestations, Genetic Variants and Therapeutic Evaluation in Sporadic Chinese Patients with Idiopathic Hypogonadotropic Hypogonadism.

Purpose: Genetic factors account for a large proportion of idiopathic hypogonadotropic hypogonadism (IHH) etiologies, although not necessarily a complete genetic basis. This study aimed to characterize the clinical presentations, genetic variants, and therapeutic outcomes of patients with sporadic IHH, which may be helpful for genetic counseling and treatment decisions.

Patients And Methods: Eleven Chinese patients with IHH were retrospectively analyzed.

Accurate and Wide-Voltage-Range Modeling of Electrowetting with a Lattice Boltzmann Approach.

The lattice Boltzmann method (LBM) has been widely used in multi-phase fluid mechanics and is known to be more computationally efficient than the traditional method of numerically solving Navier-Stokes and Cahn-Hilliard equations. Electrowetting is an important component of interfacial sciences, in which the liquid-liquid and solid-liquid interfaces are tuned by electrostatics. Modeling electrowetting using the LBM can be categorized into surface and bulk methods.

Astragaloside IV improves renal function and alleviates renal damage and inflammation in rats with chronic glomerulonephritis.

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Human pharmacokinetics prediction with an - correction factor approach and drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy for the treatment of HIV-1 infection.

Bictegravir (BIC) is a potent small-molecule integrase strand-transfer inhibitor (INSTI) and a component of Biktarvy, a single-tablet combination regimen that is currently approved for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. The properties, pharmacokinetics (PK), and drug-drug interaction (DDI) profile of BIC were characterised and .BIC is a weakly acidic, ionisable, lipophilic, highly plasma protein-bound BCS class 2 molecule, which makes it difficult to predict human PK using standard methods.

Achieving Solution-Processed Non-Doped Single-Emitting-Layer White Organic Light-Emitting Diodes through Adjusting Pyrene-Based Polyaromatic Hydrocarbon.

Single-emitting-layer white organic light-emitting diodes (SEL-WOLEDs) have developed rapidly in recent years due to the outstanding advantages of high efficiency, simple device structure, low cost, less phase separation, and stable emission color. Nevertheless, the relatively complicated host-dopant system is usually essential for most previous SEL-WOLEDs and the development of simple non-doped SEL-WOLEDs lags behind. Hence the straightforward synthesis of single-white-emitting molecules for non-doped SEL-WOLEDs still remains a great challengeable task.

Effects of an afternoon nap on sustained attention and working memory: The role of physiological arousal and sleep variables.

Taking a short midday nap has been associated with higher alertness and better cognitive task performance. Yet, the mechanisms associated with nap-dependent performance enhancement are unclear. The current study was conducted to explore the impact of physiological arousal during cognitive task and sleep architecture during a pre-task nap on post-nap behavioral outcomes.

Molecular diagnosis for growth hormone deficiency in Chinese children and adolescents and evaluation of impact of rare genetic variants on treatment efficacy of growth hormone.

Background: Growth hormone is an effective therapy for growth hormone deficiency (GHD) but with a rather variable individual sensitivity. It is unclear whether rare genetic variants may contribute to the differential GH responsiveness.

Methods: The present study aims to investigate the molecular etiology of GHD in Chinese children and adolescents and evaluate the impact of rare variants on therapeutic efficacies of GH.

Intelligent Algorithm-Based Analysis on Ultrasound Image Characteristics of Patients with Lower Extremity Arteriosclerosis Occlusion and Its Correlation with Diabetic Mellitus Foot.

Objective: The study focused on the correlation between lower extremity arteriosclerosis and diabetic mellitus (DM) foot, and it was explored by virtue of ultrasound images processed by an intelligent algorithm.

Methods: A total of 60 DM foot patients admitted to our hospital in the past three years were selected and divided into two groups according to their condition. Patients with DM foot alone were in group B (30 cases), and patients with DM foot combined with lower extremity arteriosclerosis occlusion were in group C (30 cases).

Effect of comprehensive nursing intervention on serum inflammatory factors and quality of life in patients with pelvic inflammatory disease.

Objective: To explore the improvement of quality of life of patients with pelvic inflammatory disease by comprehensive nursing intervention.

Methods: Altogether 118 patients with pelvic inflammatory disease admitted to our hospital from February 2018 to December 2019 were obtained and grouped into the control group (CG) and the experimental group (EG). The CG was given routine nursing and the EG was given comprehensive nursing intervention.

Bubble Manipulation Driven by Alternating Current Electrowetting: Oscillation Modes and Surface Detachment.

In this paper, a millimeter-sized bubble in water pending on a substrate is manipulated by applying an alternating current (AC) electric field, known as electrowetting on dielectric. In this setup, standing waves on the bubble surface are observed. The amplitude of these waves varies with frequency, and three resonance peaks (21, 76, and 134 Hz) can be identified.

A Retrospective Analysis of Patients with Short Stature in Eastern China between 2013 and 2019.

Objective: To identify the aetiology of growth and development diseases and assess the long-term effectiveness of recombinant human growth hormone (rhGH) therapy in a real-life clinical setting and provide better guidance in clinical strategy and decision making.

Methods: This retrospective study included 1145 children and adolescents with short stature admitted to the Department of Endocrinology, Affiliated Hospital of Jining Medical University, from January 2013 to December 2019, of whom 484 received rhGH treatment. The related anthropometrics and laboratory examinations were assessed in all participants.

Association between insulin-like growth factor-1 and systolic blood pressure in children and adolescents with short stature.

The relationship between insulin-like growth factor-1 (IGF-1) and systolic blood pressure (SBP) is controversial in adults and children. The purpose of this study was to investigate the relationship between the IGF-1 standard deviation score (IGF-1 SDS) and SBP in children with short stature. A cross-sectional analysis including 1315 children with short stature was conducted from March 2013 to October 2020.

Association Between Hemoglobin and Growth Hormone Peak in Chinese Children and Adolescents with Short Stature: A Cross-Sectional Study.

Objective: This research aimed to investigate the relationship between hemoglobin (Hb) and growth hormone (GH) peak in children and adolescents with short stature.

Design: This cross-sectional study included a total of 787 children and adolescents with short stature. Anthropometric and biochemical indicators were measured at baseline.

Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.

Objective: Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment.

Methods: In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy.

Boosting Upconversion Photoluminescence and Multielectrical Properties via Er-Doping-Modulated Vacancy Control in BaCaTiZrO.

The lead-free 0.5(BaCa)TiO-0.5Ba(TiZr)O (BCTZ) ceramics with Er doping have shown good upconversion photoluminescence (PL) and desirable optical temperature sensing properties.

Electric field-responsive photoluminescence color switching and reversible properties via Tb/Eu co-doped ergodic relaxor ferroelectrics.

A facile strategy of color switching has been developed through reversibly multicolored photoluminescence modulation in dual rare-earth element modified 0.94Bi0.5Na0.

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that initiate disease development are not fully understood. We demonstrate that mice with targeted loss-of-function point mutations within the AMP-activated protein kinase (AMPK) phosphorylation sites on acetyl-CoA carboxylase 1 (ACC1 Ser79Ala) and ACC2 (ACC2 Ser212Ala) have increased liver de novo lipogenesis (DNL) and liver lesions. The same mutation in ACC1 also increases DNL and proliferation in human liver cancer cells.

Room-Temperature Large and Reversible Modulation of Photoluminescence by in Situ Electric Field in Ergodic Relaxor Ferroelectrics.

Ferroelectric oxides with luminescent ions hold great promise in future optoelectronic devices because of their unique photoluminescence and inherent ferroelectric properties. Intriguingly, the photoluminescence performance of ferroelectric ceramics could be modulated by an external electric field. However, researchers face a current challenge of the diminutive extent and degree of reversibility of the field-driven modification that hinder their use in room-temperature practical applications.

[Treatment of type 2 diabetic peripheral neuropathy patients of qi-yin deficiency complicated phlegm-dampness blocking collaterals syndrome by internal application of qigui mixture and external application of qigui huoxue lotion: a clinical study].

Objective: To evaluate the efficacy of internal application of Qigui Mixture (QM) and external application of Qigui Huoxue Lotion (QHL) in treating type 2 diabetic peripheral neuropathy (DNP) patients of qi-yin deficiency complicated phlegm-dampness blocking collaterals syndrome (QYD-PDBCS), and to primarily discuss its mechanism.

Methods: Totally 62 DPN patients of QYD-PDBCS were randomly assigned to the treatment group (31 cases) and the control group (31 cases). All patients received routine comprehensive therapy.

Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives.

A series of new benzopyrone compounds were designed and synthesized and their antifungal activities in vitro were evaluated. The results showed that the benzopyrone derivatives with short terminal alkyl chain exhibited potent antifungal activity, which represent a novel class of promising leads for the development of novel non-azole antifungal agents. Compound 5j is the most potent one with MIC(80) value 1.

Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.

There is no effective treatment for cocaine addiction despite extensive knowledge of the neurobiology of drug addiction. Here we show that a selective aldehyde dehydrogenase-2 (ALDH-2) inhibitor, ALDH2i, suppresses cocaine self-administration in rats and prevents cocaine- or cue-induced reinstatement in a rat model of cocaine relapse-like behavior. We also identify a molecular mechanism by which ALDH-2 inhibition reduces cocaine-seeking behavior: increases in tetrahydropapaveroline (THP) formation due to inhibition of ALDH-2 decrease cocaine-stimulated dopamine production and release in vitro and in vivo.

Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives.

A series of novel 2-pyridone derivatives were synthesized and evaluated for their antihepatitis B virus (HBV) activity and cytotoxicity in vitro. Moderate to good activity against HBV DNA replication was observed in these 2-pyridone analogues. The most active compounds were 5d and 6l, with good inhibitory activity against HBV DNA replication (IC(50) = 0.