Research on Drug Efficacy using a Terahertz Metasurface Microfluidic Biosensor Based on Fano Resonance Effect.

Advanced biosensors must exhibit high sensitivity, reliability, and convenience, making them suitable for detecting trace samples in biological or medical applications. Currently, biometric identification is the predominant method in clinical practice, but it is complex and time-consuming. In this study, we propose an optical metasurface utilizing the Fano resonance effect, which exhibits a sharp resonance with a transmittance of 32% at 0.

How to maximize the bandwidth without increasing the noise in op-amp-based transimpedance amplifiers using positive feedback.

The bandwidth of very high gain (≥100 MV/A) transimpedance amplifiers is restricted to below 100 kHz, unless measures are employed to mitigate the effect of circuit parasitic capacitances. Current approaches involve significantly increased circuit complexity and component count. They may suffer unwanted noise pickup or destructive capacitive coupling to ground, the latter restricting the available bandwidth.

Lycopene Alleviates Chronic Stress-Induced Spleen Apoptosis and Immunosuppression via Inhibiting the Notch Signaling Pathway in Rats.

Chronic stress induction in immunosuppression and splenocyte apoptosis is commonly associated with increased susceptibility to various diseases. Lycopene (LYC) is a member of the carotenoid family with immune restoration and anti-apoptotic function. However, little is known about the mechanisms underlying the protective roles of LYC against spleen injury induced by chronic stress.

Performance characterization of a self-made terahertz photoconductive antenna.

A terahertz (THz) photoconductive antenna is prepared using, to the best of our knowledge, a novel method, which has high yield and strong stability. It eliminates the stripping process of a thin-film THz antenna and effectively prevents the toxicity of the corrosion solution, the easy damage in the transfer process, and the weak bonding with the substrate. First, a 200 µm copper wire is bundled on a low-temperature GaAs epitaxial wafer, and then the electrode of the photoconductive antenna is fabricated using the vacuum evaporation method.

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats.

Dexmedetomidine (DEX) has multiple biological effects. Here, we investigated the neuroprotective role and molecular mechanism of DEX against lipopolysaccharide (LPS)-induced hippocampal neuronal apoptosis. Sprague Dawley rats were intraperitoneally injected with LPS (10 mg/kg) and/or DEX (30 µg/kg).

Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats.

Alumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion.

Dexmedetomidine Enhances Autophagy α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury.

Background: Acute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a process of intracellular degradation related to renal homeostasis, effectively restricts inflammatory responses.

Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway.

Background: Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renoprotection of DEX is related to autophagy or the clearance of damaged mitochondria in sepsis-induced AKI.

Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases.

LPS-induced neuronal apoptosis leads to neurodegenerative diseases (NDs). However, the mechanisms underlying NDs pathogenesis remains unclear. The apoptotic response to activation of the c-Myc/chloride intracellular channel (CLIC4) pathway is directed through a mitochondrial pathway.

Luminescent isomeric Pr-Ag coordination polymers immobilized with organic sensitizer and Ag-S clusters.

A pair of luminescent heterometallic lanthanide-transition-metal coordination polymers, namely, [PrLAg(3)(SCN)(6)·H(2)O](n) (1) and [PrLAg(3)(SCN)(6)](n) (2) [L = 2,6-di(pyrazol-1-yl)pyridine], have been obtained with different cooling rates under solvothermal conditions. The two structures are pseudo- supramolecular isomers constructed via the same [PrL(NCS)(6)](3-) subunit and different Ag-S clusters, presenting diverse two-dimensional and three dimensional frameworks, respectively. In both complexes, the tridentate chelate L, acting as an organic chromophore, along with the d(10)-block Ag-S clusters, are simultaneously immobilized, and effectively sensitize the Pr(III)-based luminescence.

Theory and experiments of a tunable wavelength-selective photodetector based on a taper cavity.

We demonstrate a wavelength-selective photodetector that combines a Fabry-Perot filtering cavity (FPC) with a taper absorption cavity (TAC). The taper cavity shows a nonresonant effect but exhibits an absorption enhancement effect, so that high speed, high quantum efficiency, wide tuning range, and an ultranarrow spectral linewidth can be achieved simultaneously. Device performance was theoretically investigated by including key factors such as taper angle, finite-size diffracting-beam input, and lateral walk-off in the taper cavity.