Effect of comprehensive intervention model based on drug-psychology-society-skills on medication compliance and cognitive ability of chronic schizophrenia patients.

Background: The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.

Aim: To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.

Methods: Overall, 98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study (50 patients) and control groups (48 patients).

Preparation of molecular imprinted fluorescence sensor based on Er3+/ZnS QDs and its selective detection of ciprofloxacin in various matrices.

Background: Ciprofloxacin is a widely used antibiotic in medicine and agriculture. It can cause pollution to the environment and food, thereby affecting human health.

Objective: This study proposes the preparation of molecular imprinted fluorescent sensors and their selective detection of ciprofloxacin, with the aim of achieving specific recognition and accurate detection of ciprofloxacin.

The regulative role and mechanism of BNST in anxiety disorder.

Anxiety disorders, common yet impactful emotional disturbances, significantly affect physical and mental health globally. Many neuron circuits are associated with anxiety regulation like septo-hippocampal loop, amygdala(AMYG), bed nucleus of the stria terminalis (BNST), ventral hippocampus (vHPC), and brain regions like medial prefrontal cortex (mPFC). However, the concrete mechanism of anxiety disorder in BNST is relatively unknown.

Qualitative study on the ability of neurological nurses to manage patients with indwelling gastrointestinal canal.

Aim And Objectives: This study aims to assess the proficiency of nurses in the neurology department in managing patients with indwelling gastrointestinal canal.

Background: Many critically ill patients in neurology departments require the placement of nasoenteric tubes to provide enteral nutrition. However, in clinical practice, there exists considerable variability in nurses' competencies regarding the management of patients with nasoenteric tubes.

Two-stage continuous cultivation of microalgae overexpressing cytochrome P450 improves nitrogen and antibiotics removal from livestock and poultry wastewater.

Improper treatment of livestock and poultry wastewater (LPWW) rich in ammonium nitrogen (NH-N) and antibiotics leads to eutrophication, and contributes to the risk of creating drug-resistant pathogens. The design-build-test-learn strategy was used to engineer a continuous process using Chlorella vulgaris to remove NH-N and antibiotics. The optimized system removed NH-N at a rate of 306 mg/L/d, degraded 99 % of lincomycin, and reduced the hydraulic retention time to 4 days.

Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a mC-dependent manner.

Accumulating evidence indicates that maternal exposure to carbon black nanoparticles (CBNPs) during gestation can induce multiple system abnormalities in offspring, whereas its potential mechanism in respiratory disease is still largely unknown. In order to explore the effect of maternal exposure to CBNPs on offspring's lung and latent pathogenesis, we respectively established in vivo model of pregnant rats exposed to CBNPs and ex vivo model of lung epithelial cells treated with pups' serum of pregnant rats exposed to CBNPs. After maternal exposure to CBNPs, epithelial-mesenchymal transition (EMT) and fibrosis levels increased as a result of DDRGK1-mediated reticulophagy upregulated in offspring's lung.

Zinc-Organic Gel with Self-Catalysis-Enhanced Electrochemiluminescence as an Emitter for the Evaluation of Liver Cancer Markers.

Herein, a novel zinc-organic gel with self-catalysis-enhanced electrochemiluminescence (ECL) performance was prepared as an emitter for the first time to assemble a biosensor for ultrasensitive detection of microRNA-221 (miR-221) related to liver cancer. Interestingly, Zn served as a central ion to coordinate with multidentate ligands 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine (TATB) at room temperature to form Zn-TATB-MOGs with excellent ECL intensity. More importantly, compared to metal ions (e.

Dissolved organic carbon can alter coastal sediment phosphorus dynamic: effects of different carbon forms and concentrations.

Coastal waters are receiving increasing loads of dissolved organic carbon (DOC), differing in structural complexity and molecular weights with potential different effects on the phosphorus (P) dynamics in these waters. This study conducted an in-situ investigation in Xiangshan Harbor, China, to explore the patterns of P release in response to DOC inputs. To further elucidate the underlying mechanisms behind the DOC-affected sediment P release, a two-month mesocosm experiment was undertaken with coastal sediment (Xiangshan Harbor) to which acetate, glucose, and humic acid (representing the fermentation product, the simple available carbon, and the refractory humic-like carbon sources, respectively) were separately added to the overlying water at dosages of 0, 5, 10, and 20 mg C L.

OPA1 deficiency induces mitophagy through PINK1/Parkin pathway during bovine oocytes maturation.

In vitro embryo production (IVP) technology has been increasingly applied to beef cattle breeding. In vitro maturation (IVM) technology is the basis of IVP. However, the quality of in vitro-generated mature oocytes is still poor.

Spatiotemporal prediction of alpine wetlands under multi-climate scenarios in the west of Sichuan, China.

Background: The alpine wetlands in western Sichuan are distributed along the eastern section of the Qinghai-Tibet Plateau (QTP), where the ecological environment is fragile and highly sensitive to global climate change. These wetlands are already experiencing severe ecological and environmental issues, such as drought, retrogressive succession, and desertification. However, due to the limitations of computational models, previous studies have been unable to adequately understand the spatiotemporal change trends of these alpine wetlands.

Job Satisfaction Among Faculty in Standardized Residency Training Programs in Heilongjiang Province, China: A Cross-Sectional Study.

Purpose: Job satisfaction among faculty in standardized residency training programs has been underexplored. The objective of this study is to investigate job satisfaction among these faculty members and identify associated determinants.

Methods: An online cross-sectional survey was conducted with 4581 teachers in Heilongjiang Province from 18 to 30 May 2022, using a census method.

Thiazolidinedione-based structure modification of ergosterol peroxide provides thiazolidinedione-conjugated derivatives as potent agents against breast cancer cells through a PI3K/AKT/mTOR pathway.

Ergosterol peroxide (EP) is a steroidal compound isolated from the traditional Chinese medicine Ganoderma lucidum. However, EP is limited by its solubility and moderate potency in antitumor studies. In the present study, a series of novel ergosterol peroxide-3-thiazolidinedione derivatives were designed and synthesized, by changing the linker between ergosterol peroxide and thiazolidinedione, it is expected to obtain compounds with better antitumor activity.

Impact of scaling up health intervention coverage on reducing maternal mortality in 26 low- and middle-income countries: A modelling study.

Background: Prioritising actions is urgently needed to address the stagnation of the global maternal mortality ratio (MMR). As most maternal deaths occur in low- and middle-income countries (LMICs), we aimed to assess the impact of scaling up health intervention coverage on reducing MMR under four scenarios for 26 LMICs.

Methods: We conducted a modelling study to estimate the MMR and additional maternal lives saved by intervention by 2030 for 26 LMICs using the Lives Saved Tool (LiST).

RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway.

Background: Cerebral ischemia/reperfusion injury (CIRI), a common, universal clinical problem that costs a large proportion of the economic and disease burden. Identifying the key regulators of cerebral I/R injury could provide potential strategies for clinically improving the prognosis of stroke. Ring finger protein 13 (RNF13) has been proven to be involved in the inflammatory response.

Periconceptional Folic Acid Supplementation and Risks of Small and Large for Gestational Age at Birth: The Mediation Effects of Maternal Homocysteine Level during Pregnancy.

Background: Periconceptional folic acid supplementation (FAS) is widely recommended. However, the role of periconceptional FAS on neonatal birth weight remains unclear.

Objectives: This study aimed to explore the independent effects of periconceptional FAS on risks of small for gestational age (SGA) and large for gestational age (LGA) and to test the potential mediation role of maternal homocysteine (Hcy) during pregnancy on the above significant associations.

Identification and validation of novel genes related to immune microenvironment in polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is one of the most complicated chronic inflammatory diseases in women of reproductive age and is one of the primary factors responsible for infertility. There is substantial dispute relating to the pathophysiology of PCOS. Consequently, there is a critical need for further research to identify the factors underlying the pathophysiology of PCOS.

Design, synthesis and antitumor effects of lupeol quaternary phosphonium salt derivatives.

Lupeol is a natural pentacyclic triterpenoid with a wide range of biological activities. To improve the water solubility and targeting of lupeol, in the following study, we synthesized 27 lupeol derivatives in the first series by introducing lipophilic cations with lupeol as the lead compound. Through the screening of different cancer cells, we found that some of the derivatives showed better activity than cisplatin against human non-small cell lung cancer A549 cells, among which compound 6c was found to have an IC value of 1.

Design and synthesis of novel mitochondria-targeted ergosterol peroxide derivatives as potential anti-cancer agents.

Ergosterol peroxide (EP) is a natural steroid compound that has been reported to have significant antitumor activity. However, its poor water solubility and cellular uptake mean that it has weak efficacy against tumor cells. Herein, we designed and synthesized a series of EP derivatives with mitochondrial targeting properties.