Publications by authors named "HaiDong Kan"

Article Synopsis
  • * Researchers conducted an experiment with 22 young adults, exposing them to either ozone or clean air and measuring their heart rate variability and stress hormone levels.
  • * Results indicated that ozone exposure lowered heart rate variability and increased stress hormone levels, which may explain why exposure to ozone is linked to negative cardiometabolic health outcomes.
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Effective reducing exposure to fine particulate matter (PM) during commuting can help lower the risk of adverse health effects therefrom; however, few studies have examined the influence of different background levels of air pollution-particularly in China where PM concentrations are high globally. In this study, personal sampling was conducted to measure individual exposure during five different modes of commuting (bus, metro, car, bicycle and walking) in Shanghai, China. A total of 125 measurements were conducted for five days under haze and non-haze conditions, following which the corresponding doses of PM inhaled were estimated.

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Sensor technology has enabled the development of portable low-cost monitoring kits that might supplement many applications in conventional monitoring stations. Despite the sensitivity of electrochemical gas sensors to environmental change, they are increasingly important in monitoring polluted microenvironments. The performance of a compact diffusion-based Personal Exposure Kit (PEK) was assessed for real-time gaseous pollutant measurement (CO, O, and NO) under typical environmental conditions encountered in the subtropical city of Hong Kong.

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Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures.

Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe.

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Background: Few studies have investigated the association between exposure to fine particulate matter (PM) and infant mortality in developing countries, especially for the health effects of specific PM constituents.

Objective: We aimed to examine the association of long-term exposure to specific PM constituents with infant mortality in 15 African countries from 2005 to 2015.

Methods: Based on the Demographic and Health Surveys (DHS) dataset, we included birth history records from 15 countries in Africa and conducted a multicountry cross-sectional study to examine the associations between specific PM constituents and infant mortality.

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Article Synopsis
  • Preterm birth (PTB) is linked to significant health issues in infants and is defined as birth before 37 weeks of gestation; air pollution, particularly fine particulate matter (PM), has been suggested as a risk factor, although previous evidence was mixed.
  • A study involving 5976 live births in China found that exposure to PM during pregnancy, especially in the first trimester, increases the risk of PTB, with 7.4% of the births being preterm.
  • The study highlights that older parental age, lower maternal pre-pregnancy BMI, and lower family income further amplify the risk associated with PM exposure, emphasizing the need for pollution reduction strategies during pregnancy.
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The associations of long-term exposure to various constituents of fine particulate matter (≤2.5 μm in aerodynamic diameter, PM) air pollution with lung function were not clearly elucidated in developing countries. The aim was to evaluate the associations of long-term exposure to main constituents of PM with lung function in China.

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Indoor ammonia (NH ) pollution has been paid more and more attention in view of its health risk. However, few studies have investigated the exposure level in the non-occupational environment in China. This study systematically reviewed the indoor ammonia exposure level in different regions, the equivalent exposure concentration of different populations, and the factors that influence indoor air ammonia in residences, offices, and schools in China.

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Few cohort studies explored the associations of long-term exposure to ambient fine particulate matter with an aerodynamic diameter of 2.5 μm or less (PM) and its chemical constituents with mortality risk in rural China. We conducted a 12-year prospective study of 28,793 adults in rural Deqing, China from 2006 to 2018.

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Article Synopsis
  • Fine particulate matter (PM) is linked to health issues, especially higher blood pressure (BP), but the specific sources of PM affecting BP were unclear.
  • A study in Shanghai with 36 college students measured personal PM exposure and found seven sources, with secondary sulfate and nitrate being the most significant contributors.
  • Key findings showed that higher exposure to traffic-related PM, nitrates, and coal combustion was linked to significant increases in systolic and diastolic BP, emphasizing the need for better PM source management to protect health.
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It remains unclear whether carbon content in airway macrophages (AM) can predict personal short-term exposure to fine particulate matter (PM) air pollution and its respiratory health effects. We aimed to evaluate the pathway from personal PM exposure to adverse respiratory outcomes through AM carbon content. We designed a longitudinal panel study with 3 scheduled follow-ups among 113 non-smoking patients of chronic obstructive pulmonary disease in Shanghai, China, from April 2017 to January 2019.

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Background: Obesity is a well-known risk factor for public health. Recent studies found that greenness exposure may protect against obesity. However, the accumulated evidence on associations of greenness-obesity is inconsistent and most of them are from developed countries.

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Background: The health impacts of ambient air pollution impose large costs on society. Although all people are exposed to air pollution, the older population (ie, those aged ≥60 years) tends to be disproportionally affected. As a result, there is growing concern about the health impacts of air pollution as many countries undergo rapid population ageing.

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The assessment of premature mortality associated with the dramatic changes in fine particulate matter (PM) and ozone (O) has important scientific significance and provides valuable information for future emission control strategies. Exposure data are particularly vital but may cause great uncertainty in health burden assessments. This study, for the first time, used six methods to generate the concentration data of PM and O in China between 2014 and 2018, and then quantified the changes in premature mortality due to PM and O using the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE) model.

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Background: Previous studies have suggested acute effects of ambient fine particulate matter (PM) air pollution on respiratory health among children, but evidence for PM constituents and respiratory health were still limited.

Objectives: To investigate associations of short-term exposure to PM and its constituents with airway inflammation, lung function, and airway microbiota in children.

Methods: We conducted a longitudinal panel study with 3 repeated health measurements among 62 children in Shanghai, China from November 2018 to June 2019.

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The toxicity and widespread exposure opportunity of diesel exhaust particles (DEP) has aroused public health concerns. This study aimed to investigate the acute effect of DEP and different fractions exposure on blood coagulation function in mice. In this study, nine- week-old C57BL/6J male mice were divided into four exposure groups (with 15 mice in each group).

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Background: Studies have reported that prenatal exposure to fine particulate matter (PM) might be associated with adverse birth outcomes in offspring. However, evidence with regard to the effects of prenatal exposure to PM and, especially, its main chemical constituents on offspring's weight in childhood is limited and inconsistent.

Objectives: The present study aimed to examine associations of prenatal exposure to PM total mass and its chemical constituents in each trimester with children's weight from birth to 6 years of age using data from Shanghai-Minhang Birth Cohort Study.

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Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a multicity, multicountry setting.

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Considerable studies show that maternal exposure to ambient fine particulate matter (PM) programs offspring's susceptibility to obesity. However, few studies have investigated the effect of paternal PM exposure on offspring's energy homeostasis. This study thus tested whether paternal PM exposure programs offspring's energy homeostasis.

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Objective: To evaluate the short term associations between nitrogen dioxide (NO) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol.

Design: Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis.

Setting: 398 cities in 22 low to high income countries/regions.

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Background: Few studies have explored the short-term effects of ultrafine particles (UFPs, particles < 0.1 μm) air pollution on the exacerbations of pediatric respiratory diseases.

Objectives: We aimed to evaluate short-term association between UFP and emergency-department visits (EDVs) for main pediatric respiratory diseases.

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China has been in the implementation phase of Domestic Ship Emission Control Areas (DECAs) regulation to reduce emissions of air pollutants from ships near populated areas since 2016. The Yangtze River Delta (YRD) is one of the busiest port clusters in the world, accounting for 11% of global seaborne cargo throughput, so future improvements in shipping emission controls may still be important in this region. To assess the impact of future ship emissions on air quality of coastal areas, this study evaluates emissions reductions and air quality in 2030 for three scenarios (business as usual, stricter regulations, and aspirational policies) representing increasing levels of control compared with a base year of 2015.

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Epidemiological evidences have indicated that fine particulate matter (PM ) exposure is associated with the occurrence and development of hypertension. The present study aims to explore the effects of parental PM exposure on blood pressure in offspring and elucidate the potential mechanism. The parental male and female C57BL/6 mice were exposed to concentrated PM or filtered air (FA) using Shanghai Meteorological and Environmental Animal Exposure System (Shanghai-METAS) for 16 weeks.

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Article Synopsis
  • The study investigates the effect of short-term exposure to particulate matter (PM) on inflammation and oxidative stress biomarkers in healthy adults using non-invasive samples like saliva and urine.
  • Researchers found that salivary biomarkers (CRP and TNF-α) showed quicker responses to PM exposure, with significant increases observed within 12 hours, while urinary biomarkers (8-iso-PGF) showed changes after 24 hours.
  • The results suggest that key time windows for detecting these responses are within 6-12 hours for salivary markers and 24 hours or more for urinary markers, indicating the potential of using bio-samples to assess the impact of air pollution on health.
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Background: Exposure to fine particulate matter (PM) has been linked with adverse cardiorespiratory health conditions. However, evidence for PM constituents is still scarce, especially among patients with chronic obstructive pulmonary disease (COPD).

Objective: To investigate the associations of short-term exposure to different chemical constituents of PM with measures of cardiac and lung function in COPD patients.

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