Exploring core symptoms and interrelationships among symptoms in children with acute leukemia during chemotherapy: A network analysis.

Purpose: Children with acute leukemia have suffered from a considerable symptom burden during chemotherapy. However, few studies have focused on exploring the mechanisms among symptoms in children with acute leukemia. Our study aims to explore core symptoms and describe the interrelationships among symptoms in children with acute leukemia during chemotherapy.

Identifying central symptom clusters and correlates in children with acute leukemia undergoing chemotherapy: a network analysis.

Background: Previous studies have examined symptom clusters in children with acute leukemia, yet a knowledge gap persists regarding central symptom clusters and their influencing factors. By identifying these central clusters and associated factors, healthcare providers can enhance their understanding and effective management of symptoms. Our study seeks to address this gap by identifying symptom clusters, exploring central clusters, and investigating the demographic and health-related factors associated with these clusters in children with acute leukemia undergoing chemotherapy.

Does Monitoring Total and Free Polymyxin B1 Plasma Concentrations Predict Polymyxin B-Induced Nephrotoxicity? A Retrospective Study in Critically Ill Patients.

Introduction: The correlation between total and free polymyxin B (PMB including PMB1 and PMB2) exposure in vivo and acute kidney injury (AKI) remains obscure. This study explores the relationships between plasma exposure of PMB1 and PMB2 and nephrotoxicity, and investigates the risk factors for PMB-induced acute kidney injury (AKI) in critically ill patients.

Methods: Critically ill patients who used PMB and met the criteria were enrolled.

Establishing and evaluating physician-pharmacist collaborative clinics to manage patients with type 2 diabetes in primary hospitals in Hunan province: study protocol of a multi-site randomized controlled trial in the era of COVID-19 pandemic.

Background: The COVID-19 pandemic has exerted an unprecedented and universal impact on global health system, resulting in noticeable challenges in traditional chronic disease care, of which diabetes was reported to be most influenced by the reduction in healthcare resources in the pandemic. China has the world's largest diabetes population, and current diabetes management in China is unsatisfactory, particularly in rural areas. Studies in developed countries have demonstrated that physician-pharmacist collaborative clinics are efficient and cost-effective for diabetes management, but little is known if this mode could be adapted in primary hospitals in China.

[Effect of two manual mixing methods on the accuracy of alginate impression].

Purpose: The effect of clockwise mixing method and clockwise combined eight-shaped mixing method on the accuracy of alginate impression was compared.

Methods: From march to April 2018, 40 dental restoration cases in the Department of Stomatology, Zhoupu Hospital, Pudong District, Shanghai were selected. Two nurses and the same doctor treated 40 patients with single crown porcelain restoration.

[Further Exploration on the Essence of Yin Deficiency Caused Fire Hyperactivity Syndrome in Precocious Puberty Children Patients].

In this paper 200 girls with precocious puberty or advanced puberty were clinically sur- veyed, and the literatures of traditional Chinese medicine (TCM) for treating precocious puberty in previ- ous 33 years were retrospectively analyzed. By conjecturing syndromes from symptoms and identifying syndrome types from efficacies of TCM drugs, authors proved that Gan yin deficiency syndrome occupies the same important position as Shen yin deficiency syndrome, or even more important position in syn- drome based treatment of precocious puberty children patients with yin deficiency caused fire hyperactivity syndrome. Therefore, Gan yin deficiency syndrome cannot be neglected in treating precocious puberty pa- tients.

The transport mechanism of monocarboxylate transporter on spinosin in Caco-2 cells.

Objectives: The aim of this study was to determine the uptake mechanism of spinosin (SPI) by the monocarboxylic acid transporters (MCTs) in Caco-2 cells.

Methods: The Caco-2 cells were pretreated with various monocarboxylic acids, and the uptake of spinosin from Caco-2 cells was measured by High Performance Liquid Chromatography (HPLC).

Key Findings: Preloading of various monocarboxylic acids enhanced the uptake of SPI, especially salicylic acid (a substrate of MCTs) had a 23.

[Ozone source apportionment at urban area during a typical photochemical pollution episode in the summer of 2013 in the Yangtze River Delta].

With the fast development of urbanization, industrialization and mobilization, the air pollutant emissions with photochemical reactivity become more obvious, causing a severe photochemical pollution with the characteristics of high ozone concentration. However, the ozone source identification is very complicated due to the high non linearity between ozone and its precursors. Thus, ways to reduce ozone is still not clear.

Cinnamic aldehyde treatment alleviates chronic unexpected stress-induced depressive-like behaviors via targeting cyclooxygenase-2 in mid-aged rats.

Ethnopharmacological Relevance: COX-2 has been considered as a potent molecular target for prevention and therapy of depression. However, a recent study showed that COX-2 inhibitor does not improve depressive symptoms in persons aged 70 and over. Therefore, whether treatments targeting COX-2 have a clinical efficacy in depression, especially elderly individuals, remains unclear.

[Characteristics of particulate matters and its chemical compositions during the dust episodes in Shanghai in spring, 2011].

A continuous air quality observation was conducted in the urban area of Shanghai from April 28 to May 18 in 2011. The mass concentration of particle matters and main chemical compositions of fine particle were measured and analyzed. The mass concentrations of PM10 and PM2.

[Emission factors and PM chemical composition study of biomass burning in the Yangtze River Delta region].

The emission characteristics of five typical crops, including wheat straw, rice straw, oil rape straw, soybean straw and fuel wood, were investigated to explore the gas and particulates emission of typical biomass burning in Yangzi-River-Delta area. The straws were tested both by burning in stove and by burning in the farm with a self-developed measurement system as open burning sources. Both gas and fine particle pollutants were measured in this study as well as the chemical composition of fine particles.

[Aging and mixing state of particulate matter during aerosol pollution episode in autumn Shanghai using a single particle aerosol mass spectrometer (SPAMS)].

A single particle aerosol mass spectrometer (SPAMS) was applied to characterize the size distribution (200 nm-2.0 microm) and chemical compositions of ambient particles during a polluted event from 11th to 18th, November 2011. OCEC, METAL, EC, SECONDARY and K-Na types of particulates were the dominant groups observed in hazy day period, which were 27.

[Emission strength and source apportionment of volatile organic compounds in Shanghai during 2010 EXPO].

The emission strength of VOCs was estimated in the study, based on the volatile organic compounds (VOCs) measurement results. Air mass backward trajectories were computed and cluster analysis was done combining with the corresponding air pollution indexes and VOCs concentrations. Source apportionment of VOCs was studied using receptor model.

[Source profile and chemical reactivity of volatile organic compounds from vehicle exhaust].

Light-duty gasoline taxis (LDGT) and passenger cars (LDGV), heavy-duty diesel buses (HDDB) and trucks (HDDT), gasoline motorcycles (MC) and LPG scooters (LPGS), were selected for tailpipe volatile organic compounds (VOCs) samplings by using transient dynamometer and on road test combined with SUMMA canisters technology. The samples were tested by GC-MS to analyze the concentration and species composition of VOCs. The results indicate that light-duty gasoline automobiles have higher fractions of aromatic hydrocarbons, which account for 43.

[Rosuvastatin attenuates vascular endothelial adhesiveness in apolipoprotein E-deficient mice].

Objective: To investigate the anti-inflammatory effects on the vessel wall of rosuvastatin in apolipoprotein E-deficient mice.

Methods: Eight-week-old apolipoprotein E-deficient mice fed a normal chow diet were treated with vehicle or various doses of rosuvastatin (1, 5, or 20 mg/kg) by subcutaneous injection for 2 or 6 weeks prior to sacrifice. Endothelial adhesiveness for monocytes was determined by functional binding assay.

[Real world instantaneous emission simulation for light-duty diesel vehicle].

Core architecture and input parameters of CMEM model were introduced to simulation the second by second vehicle emission rate on real world by taking a light-duty diesel car as a case. On-board test data by a portable emission measurement system were then used to validate the simulation results. Test emission factors of CO, THC, NO(x) and CO2 were respectively 0.

[Protective effects of edaravone on renal ischemia-reperfusion injury in rats].

Objective: To investigate the effect of edaravone on renal ischemia-reperfusion injury in rats.

Methods: Fifty rats were randomly divided into five groups: sham operation group (Group A), renal ischemia-reperfusion group (Group B) and edaravone treated groups (Group C1, Group C2 and Group C3 with different drug dosages). Serum maleic dialdehyde (MDA) and superoxide dismutase (SOD), renal MDA and SOD, serum creatinine (Cr), blood urea nitrogen (BUN) were measured after the rat kidney was ischemia-reperfused for 24 hours.

[Regional air pollution characteristics simulation of O3 and PM10 over Yangtze River Delta region].

Based on the TRACE-P emission data and a Shanghai local emission inventory, the regional air quality model Models-3/CMAQ was applied with the mesoscale model MM5 to simulate the distribution and transport status of O3 and PM10 in the Yangtze River Delta (YRD) in January and July 2001. Ten days' hourly monitoring data at Shanghai monitoring sites were used to verify the model performance. Results show that the correlation coefficients between monitoring and simulation data of O3 and PM10 are 0.

[Double filtration plasmapheresis in treatment of hyperlipidemic acute pancreatitis].

Objective: To investigate the therapeutic effects of double filtration plasmapheresis(DFPP) in treatment of hyperlipidemic acute pancreatitis.

Methods: Nine patients with acute hyperlipidemic pancreatitis were treated with DFPP in addition to the conventional therapeutic measures. The clinical symptoms,serum levels of triglyceride (TG) and APACHE II scores were observed before and after DFPP.

[Study of on-board emission measurement for heavy-duty diesel vehicle and its impact with load].

Real world vehicle emission tests were conducted on two heavy-duty diesel trucks on un-loaded and loaded condition by using a portable emission measurement system. By analysis, the results indicate high fuel consumption and emission rates are concentrated on the high speed and acceleration areas of the speed-acceleration emission maps and the areas are much wider on loaded condition. The impact of load on fuel use and emissions will be highest while the vehicle is cruising or accelerating on (30 +/- 2.