Publications by authors named "Hai-yan SHI"

Introduction: A rapid, accurate, and specific ultrafiltration with ultra-performance liquid chromatographic-tandem mass spectrometry method was validated for the simultaneous determination of the protein binding rate of atorvastatin in uremic patients. Methods: The plasma samples were centrifuged at 6,000 r/min for 15 min at 37°C and the ultrafiltrate was collected. An ACQUITY UPLC® BEH C18 Column with gradient elution of water (0.

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With the advancement of Artificial Intelligence (AI), it has had a profound impact on medical education. Understanding the advantages and issues of AI in medical education, providing guidance for educators, and overcoming challenges in the implementation process is particularly important. The objective of this study is to explore the current state of AI applications in medical education.

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Objective: To explore the differences in ultra-processed food (UPF) consumption across different socioeconomic status (SES) levels.

Methods: Data on UPF consumption (grams/day) were derived from the 2017-2018 National Health and Nutrition Examination Survey. The analysis controlled for age, marital status, race, and sex.

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Article Synopsis
  • * Data from the 2020 'China County Statistical Yearbook' and 'China City Statistical Yearbook' revealed a clustering pattern of nursing homes, with most differences in availability found within provinces and regions rather than between them.
  • * The findings indicate that while nursing home resources in China are growing, there is a need for further optimization and the development of targeted elderly care policies to better meet the needs of older individuals.
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To establish a population pharmacokinetic (PopPK) model of posaconazole suspension in Chinese hematopoietic stem cell transplantation (HSCT) patients and to recommend an optimal dosing regimen. A single-center, retrospective, model-based study was conducted in 62 Chinese patients, including 103 with posaconazole plasma concentrations. PopPK analysis using NONMEM software.

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Background: Physical activity (PA) exerts an important influence on glycemic control in type 2 diabetes (T2D) patients. Alterations in body composition in patients with T2D may be involved in the overall pathophysiologic process, but PAs and alterations in body composition have been poorly studied.

Methods: A total of 615 patients with T2D were selected by convenient sampling.

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Background: The present study aims to determine the impact of different cuff diameters on the cuff pressure of endotracheal tubes (ETTs) when the trachea is adequately sealed.

Methods: In the present single-center clinical trial, adult patients who underwent cardiothoracic surgery were assigned to use ETTs from 2 brands (GME and GZW). The primary endpoint comprised of the following: cuff diameter, inner diameter of the ETT, manufacturer, and the number of subjects with tracheal leakage when the cuff pressure was 30 cm H2O.

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JOURNAL/nrgr/04.03/01300535-202501000-00035/figure1/v/2024-05-14T021156Z/r/image-tiff Our previous study found that rat bone marrow-derived neural crest cells (acting as Schwann cell progenitors) have the potential to promote long-distance nerve repair. Cell-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular communication.

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Brachial plexus injury (BPI) with motor neurons (MNs) damage still remain poor recovery in preclinical research and clinical therapy, while cell-based therapy approaches emerged as novel strategies. Previous work of rat skin precursor-derived Schwann cells (SKP-SCs) provided substantial foundation for repairing peripheral nerve injury (PNI). Given that, our present work focused on exploring the repair efficacy and possible mechanisms of SKP-SCs implantation on rat BPI combined with neurorrhaphy post-neurotomy.

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Background: Radical surgery is the most commonly used treatment for hepatocellular carcinoma (HCC). However, the surgical effect remains not ideal, and prognostic evaluation is insufficient. Furthermore, clinical intervention is rife with uncertainty and not conducive to prolonging patient survival.

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Background: Meropenem is frequently used to treat severe infections in critically ill children. However, pharmacokinetic data on meropenem in children with end-stage renal disease (ESRD) undergoing prolonged intermittent renal replacement therapy (PIRRT) is limited. Our objectives were to evaluate meropenem clearance in a child with ESRD with and without PIRRT, compare the results to previous continuous renal replacement therapy studies in children, toddlers and neonates, and assess whether the currently used dose of meropenem is sufficient.

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Objectives: The cuff pressures > 30 cmHO may create a seal in the trachea. The objective of this study was to identify risk factors associated with lack of tracheal sealing by an endotracheal cuff inflated to > 30 cmHO in patients undergoing mechanical ventilation.

Methods: This prospective cross-sectional study was conducted from 2019 to 2020 in the cardiothoracic intensive care unit and respiratory medical care unit of a Hospital in Nantong, China.

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Currently, the use of targeted drugs such as tyrosine kinase inhibitors (TKIs) plays an important role in clinical therapy. As the number of approved TKIs continues to increase, existing analysis methods will not be able to meet the growing needs, and will hamper the development of therapeutic drug monitoring (TDM) of TKIs. Based on LC-MS/MS technology, this study tends to develop and validate a multi-component analysis method for simultaneous determination of the concentrations of 39 TKIs in plasma.

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Two dimeric Ln-Cr clusters with formula {Ln(HO)[LnCr(L)(CHCOO)(μ-OH)(HO)]}·(ClO)·HO (Ln = Gd, = 35 for 1 and Ln = Dy, = 45 for 2, HL = 2-pyrazinecarboxylic acid) were obtained by a ligand-controlled hydrolytic method with a mixed ligand system (2-pyrazinecarboxylic acid and acetate). Single crystal structure analysis showed that two trigonal bipyramids of [GdCr(μ-OH)] worked as building blocks in constructing the metal-oxo cluster core of [GdCr(μ-OH)] by sharing a common top - a Cr ion. Additionally, compound 1 forms a three-dimensional framework with a one-dimensional nanopore channel along the -axis through a hydrogen-bond interaction between the cationic cluster core and the free mononuclear cation [Gd(HO)] and the π-bond interactions of the pyrazine groups on the two cationic cluster cores.

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Aims: Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical practice.

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Peripheral nerve fibroblasts play a critical role in nerve development and regeneration. Our previous study found that peripheral nerve fibroblasts have different sensory and motor phenotypes. Fibroblasts of different phenotypes can guide the migration of Schwann cells to the same sensory or motor phenotype.

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Article Synopsis
  • The study aimed to assess the effectiveness and tolerance of a model-based dosing regimen of piperacillin/tazobactam for treating early-onset sepsis (EOS) in neonates, a condition with significant health risks.
  • Conducted as a prospective phase II clinical study, the trial involved 49 neonates who received the determined dosing regimen, with a focus on achieving proper drug concentrations to effectively fight the infection.
  • The results showed that most neonates (96%) met the target drug concentration levels, and while 16% experienced treatment failure, there were no severe adverse events or infection-related deaths within the first month.
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The elucidation of CYP2D6 developmental pharmacogenetics in children has improved, however, these findings have been largely limited to studies of Caucasian children. Given the clear differences in CYP2D6 pharmacogenetic profiles in people of different ancestries, there remains an unmet need to better understand the developmental pharmacogenetics in populations of different ancestries. We sought to use loratadine as a substrate drug to evaluate the effects of ontogeny and pharmacogenetics on the developmental pattern of CYP2D6 in Chinese pediatric patients.

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Purpose: Considering prior investigations on reductions of renal multidrug resistance-associated protein (MRP) 2 and 4 transporters in mice with acute lymphoblastic leukemia (ALL), we sought to characterize the underlying mechanisms responsible for IL-6/STAT3/PXR-mediated changes in the expression of MRP2 and MRP4 in ALL.

Subjects And Methods: ALL xenograft models were established and intravenously injected with methotrexate (MTX) of MRPs substrate in NOD/SCID mice. Protein expression of MRPs and associated mechanisms were detected by Western blotting and immunocytochemistry.

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Background: Population pharmacokinetic evaluations have been widely used in neonatal pharmacokinetic studies, while machine learning has become a popular approach to solving complex problems in the current era of big data.

Objective: The aim of this proof-of-concept study was to evaluate whether combining population pharmacokinetic and machine learning approaches could provide a more accurate prediction of the clearance of renally eliminated drugs in individual neonates.

Methods: Six drugs that are primarily eliminated by the kidneys were selected (vancomycin, latamoxef, cefepime, azlocillin, ceftazidime, and amoxicillin) as 'proof of concept' compounds.

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Article Synopsis
  • Ceftazidime is a powerful antibiotic used to treat infections, but dosing for neonates and young infants can be confusing due to various factors affecting medication absorption and effectiveness.
  • A study was conducted on 146 neonates and infants to create a better dosage model by analyzing blood samples and using advanced statistical methods.
  • The findings suggest specific dosage regimens based on age and gestational factors, optimizing treatments for sepsis in this vulnerable population.
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Objective: The aim of the present study was to determine the quality marker (Q-Markers) of against thrombus through an integration of investigations on its antithrombotic effect, content determination and spectrum-effect correlation analysis.

Methods: Based on the concept of Q-Marker, was investigated for the identification of chemical component. The pharmacological effects on arachidonic acid-induced thrombosis in zebrafish were also investigated.

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Article Synopsis
  • The study investigates how augmented renal clearance (ARC) affects the pharmacokinetics of cefathiamidine, an antibiotic commonly used in infants, by analyzing plasma samples from 20 infants with ARC.
  • Using advanced modeling techniques, researchers developed a population pharmacokinetic model showing that weight and age significantly influence cefathiamidine metabolism in this age group.
  • Recommended dosing regimens were established based on simulations to ensure effective antibiotic concentrations, suggesting doses of 100 mg/kg/day every 12 hours for certain bacteria, adjusted for others based on their minimum inhibitory concentration (MIC).
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