[Evaluation of a modified maxillary protraction appliance for the treatment of patients with skeletal Class Ⅲ malocclusion associated with crowding].

Purpose: To investigate the efficacy of a modified maxillary protraction appliance in patients of skeletal Class Ⅲ with crowding.

Methods: Forty patients with skeletal Class Ⅲ malocclusion were divided into two groups, with 20 patients in each group. The experimental group had molar in a neutral or distal relationship and applied a modified maxillary protraction appliance, while the control group had molar mesial relationship and applied a conventional maxillary protraction appliance.

Single-Molecule White Circularly Polarized Photoluminescence and Electroluminescence from Dual-Emission Enantiomers.

The strategy of integrating conformational isomerization donors and chiral acceptors in a single molecule was proposed to construct white circularly polarized luminescence (WCPL) materials in this work. Consequently, a pair of dual-emission enantiomers, namely (R/S)-DO-PTZ, were designed and synthesized, which displayed white emission with blue and yellow dual-emission bands in solution and solid films with Commission Internationale de l'Eclairage (CIE) coordinates of (0.30, 0.

Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.

The intestine is prone to radiation damage in patients undergoing radiotherapy for pelvic tumors. However, there are currently no effective drugs available for the prevention or treatment of radiation-induced enteropathy (RIE). In this study, we aimed at investigating the impact of indole-3-carboxaldehyde (I3A) derived from the intestinal microbiota on RIE.

A calix[3]carbazole-based cavitand: synthesis, structure and its complexation with fullerenes.

A calix[3]carbazole-based cavitand was conveniently synthesized. It was found that the cavitand with adjustable conformation could show excellent complexation with fullerenes C and C in both solution and the solid state. Moreover, the crystal structures of the host-guest complexes show that the cavitand can stack into channel-like architectures, in which fullerenes are orderly arranged inside.

Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis.

Purpose: Radiation-induced intestinal injury (RIII) commonly occur during abdominal-pelvic cancer radiation therapy; however, no effective prophylactic or therapeutic agents are available to manage RIII currently. This study aimed to clarify the potential of probiotic consortium supplementation in alleviating RIII.

Methods And Materials: Male C57BL/6J mice were orally administered a probiotic mixture comprising Bifidobacterium longum BL21, Lactobacillus paracasei LC86, and Lactobacillus plantarum Lp90 for 30 days before exposure to 13 Gy of whole abdominal irradiation.

A general supramolecular strategy for fabricating full-color-tunable thermally activated delayed fluorescence materials.

Developing a facile and feasible strategy to fabricate thermally activated delayed fluorescence materials exhibiting full-color tunability remains an appealing yet challenging task. In this work, a general supramolecular strategy for fabricating thermally activated delayed fluorescence materials is proposed. Consequently, a series of host-guest cocrystals are prepared by electron-donating calix[3]acridan and various electron-withdrawing guests.

Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo.

The small intestine exhibits remarkable sensitivity to ionizing radiation (IR), which significantly hampers the effectiveness of radiotherapy in the treatment of abdominal and pelvic tumors. Unfortunately, no effective medications are available to treat radiation-induced intestinal damage (RIID). Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside), is a coumarin derivative extracted from the Chinese herb Cortex Fraxini.

Polyfluoroalkyl Chain-Based Assemblies for Biomimetic Catalysis.

Amphiphobic fluoroalkyl chains are exploited for creating robust and diverse self-assembled biomimetic catalysts. Long terminal perfluoroalkyl chains (C F with n=6, 8, and 10) linked with a short perhydroalkyl chains (C H with m=2 and 3) were used to synthesize several 1,4,7-triazacyclononane (TACN) derivatives, C F -C H -TACN. In the presence of an equimolar amount of Zn ions that coordinate the TACN moiety and drive the self-assembly into micelle-like aggregates, the critical aggregation concentration of polyfluorinated C F -C H -TACN⋅Zn was lowered by ∼1 order of magnitude compared to the traditional perhyroalkyl counterpart with identical carbon number of alkyl chain.

Compound heterozygous p.L483P and p.S310G mutations in GBA1 cause type 1 adult Gaucher disease: A case report.

Background: Gaucher disease (GD) is caused by a gene mutation that leads to decreased acid β-glucosidase activity [glucocerebrosidase (GCase)]. This study aimed to identify and characterise compound heterozygous mutations in in a patient with type 1 GD.

Case Summary: Here, we report a rare adult-onset type 1 GD in a 46-year-old female patient with clinical manifestations of giant spleen, thrombocytopenia, and bone pain, diagnosed by enzymatic and genetic testing.

Efficacy and safety of radiotherapy plus anti-PD1 versus transcatheter arterial chemoembolization plus sorafenib for advanced hepatocellular carcinoma: a real-world study.

Background: The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of radiotherapy (RT) plus monoclonal antibody against programmed cell death 1 (anti-PD1) versus TACE plus sorafenib for patients with advanced HCC.

Methods: Patients with advanced HCC who treated with RT plus anti-PD1 and TACE plus sorafenib were enrolled.

[Effects of astragaloside Ⅳ on inflammatory response and percentage of peripheral blood Th17 cells in mice with ulcerative colitis].

This study aimed to investigate the anti-inflammatory effect of astragaloside Ⅳ in mice with ulcerative colitis(UC) and its effect on the percentage of peripheral blood T helper(Th17) cells. Following the establishment of UC mouse model with 2% sodium dextran sulfate(DSS), mice in the positive control group and low-and high-dose astragaloside Ⅳ groups were treated with corresponding drugs by gavage. Disease activity index(DAI) was calculated, and serum interleukin-17(IL-17), tumor necrosis factor-α(TNF-α), and transforming growth factor-β(TGF-β) levels were assayed by ELISA.

A Green Fluorescent Nitrogen-Doped Aromatic Belt Containing a [6]Cycloparaphenylene Skeleton.

The design and synthesis of nitrogen-doped aromatic belts with conjugated structures still remain a challenge. Here, we report the first nitrogen-doped aromatic belt with a [6]cycloparaphenylene skeleton, which is conveniently synthesized from the easily available calix[3]carbazole. The aromatic belt has a rigid conjugated structure and deep cavity, and it can encapsulate one dichloromethane both in solution and in the solid state.

An axially chiral thermally activated delayed fluorescent emitter with a dual emitting core for a highly efficient organic light-emitting diode.

An axially chiral TADF emitter, 4tBuCzPN, with a dual emitting core was easily synthesized. Compared with the TADF emitter 2tBuCzPN with the PLQY of 29% and EQE of 5.3%, 4tBuCzPN showed a significantly increased PLQY (74%) and EQE (20.

Green economic efficiency and its influencing factors in China from 2008 to 2017: Based on the super-SBM model with undesirable outputs and spatial Dubin model.

Due to the pressure of global ecological degradation, the coordination of economic increase and ecological protection has drawn attention from policymakers and practitioners. Green economic efficiency (GEE) is a comprehensive index to measure economic, social, and environmental development. As China is the second-biggest economy in the world with high-energy consumption, it is necessary to investigate its green economy efficiency.

Sign inversions of circularly polarized luminescence for helical compounds by chemically fine-tuning operations.

Sign inversions of circularly polarized luminescence (CPL) for the hydro[5]helicene and [5]helicene derivatives were discovered and studied experimentally and theoretically. The inverted CPL signs from the hydro[5]helicene to [5]helicene derivatives were realized by one-step oxidation. The introduction of triphenylamine (TPA) subunits into the helical skeletons also led to the sign inversion of CPL only when there existed an enhanced intramolecular charge-transfer state with a small enough Egap.

The coexistence of ROS1-rearranged lung adenocarcinoma and pulmonary tuberculosis in a critical ill young patient.

The coexistence of lung cancer and pulmonary tuberculosis (PTB) is uncommon in young patients. We report a case of 22-year-old man who presented with a one-month history of chest pain, cough, slight haemoptysis and weight loss. Following two acid fast bacilli positive sputum samples, a diagnosis of TB was concluded.

Advances in helicene derivatives with circularly polarized luminescence.

Chiral materials have been widely present in people's lives, and their in-depth application research is underway. Generally, the circularly polarized light obtained from nonpolarized light through filters would result in brightness loss. Scientists have found that chirality can be introduced into organic compounds to obtain circularly polarized luminescence (CPL).

Phthalimide-based "D-N-A" emitters with thermally activated delayed fluorescence and isomer-dependent room-temperature phosphorescence properties.

Phthalimide-based "D-N-A" emitters o-AI-Cz, m-AI-Cz and p-AI-Cz showed TADF and RTP properties due to their small ΔEST in both film and crystalline states. In particular, o-AI-Cz exhibited an ultralong RTP with a lifetime of 602 ms in air and remarkable afterglow, which could allow it to be used as a security ink for application in anti-counterfeiting materials. Moreover, o-AI-Cz showed intense intramolecular interaction between the donor and the acceptor subunits, while p-AI-Cz could form regular hexagonal pores with a diameter of 13.

Novel oxacalix[2]arene[2]triazines with thermally activated delayed fluorescence and aggregation-induced emission properties.

New kinds of oxacalixarenes based on the triazine moiety have been synthesized, which showed highly twisted conformations and small ΔEST, as well as temperature-dependent transient PL decay curves, indicating the excellent thermally activated delayed fluorescence properties. Moreover, the oxacalixarenes also exhibited apparent aggregation-induced emission properties in THF/H2O mixtures.

Metal-free construction of contiguous quaternary stereocentres with a polycyclic framework.

A series of contiguous all-carbon quaternary stereocentres with an arene-annulated polycyclic framework were constructed efficiently by a metal-free and atom economic acid-catalyzed method. The reactions could be performed by acid-catalyzed cationic cyclization and rearrangement under mild conditions. Moreover, the resulting polycyclic products showed highly twisted architectures with two perpendicular planes.

Insights into the effect of donor ability on photophysical properties of dihydroindeno[2,1-c]fluorene-based imide derivatives.

The photophysical properties of dihydroindeno[2,1-c]fluorene-based imide (DHIFI) derivatives were investigated by steady-state and time-resolved spectroscopy as well as quantum chemical calculations. The hybridized local excited and charge transfer state (HLCT) was introduced to interpret the intercrossing of localized excited (LE) and charge transfer (CT) states. The large extent of CT in the HLCT state of a molecule with a strong electron donor (dimethylaniline) at the terminal site results in strong interaction between the dipole moments of the excited state and polar solvents.

Chiral Nanoparticles with Full-Color and White CPL Properties Based on Optically Stable Helical Aromatic Imide Enantiomers.

Chiral self-assembled organic nanoparticles with circularly polarized luminescence (CPL) properties can be utilized as a new kind of chiral luminescent materials for practical applications. However, no such chiral organic nanoparticles with full-color and white CPL properties have been reported so far. Herein, five pairs of self-assembled chiral nanoparticles based on optically stable helical aromatic amide enantiomers were conveniently obtained.

Synthesis, chiroptical properties, and self-assembled nanoparticles of chiral conjugated polymers based on optically stable helical aromatic esters.

By Suzuki coupling reaction, three pairs of chiral conjugated polymers with optically stable helical aromatic ester subunits as the main-chain were designed and synthesized. Polymers (+)-P-P1 and (-)-M-P1, (+)-P-P2 and (-)-M-P2 showed strong fluorescence emission, strong mirror image CD and circularly polarized luminescence (CPL) signals in THF. For polymers (+)-P-P3 and (-)-M-P3, containing the tetraphenylethene (TPE) moiety, they not only showed obvious aggregation induced enhancement emission (AIEE), but also exhibited mirror image CD signals and aggregation-induced enhancement CPL signals in THF-water mixtures.