Publications by authors named "Hai-xing Zhu"
Purpose: PRDX (Peroxiredoxin) family has involved in breast cancer tumorigenesis from the evidence obtained from cell lines, human tissues and mouse models. Nonetheless, the diversified expression patterns, coupled with the prognostic values of PRDX family, still require explanation. This study aimed at investigating the clinical importance and biological of PRDXs in breast cancer.
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- - The study investigated the effectiveness of laparoscopic surgery versus open surgery in patients with advanced gastric neuroendocrine carcinomas (G-NECs) by analyzing data from 175 patients who underwent radical gastrectomy.
- - Results showed that patients who had laparoscopic surgery experienced shorter recovery times in terms of ambulation, first flatus, and dietary progression, while post-operative complication rates and long-term survival rates were similar between both surgical methods.
- - The conclusion is that both laparoscopic and open gastrectomy provide comparable short-term outcomes and oncologic effectiveness for treating advanced G-NECs, suggesting that laparoscopic surgery could be an effective option.
Background: Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), are exposed to a higher risk of developing lung cancer. Chronic inflammation may play an important role in the lung carcinogenesis among those patients.
View Article and Find Full Text PDFImpaired self-healing capacity in airway epithelia lacking aquaporin-3.
Respir Physiol Neurobiol
November 2016
In this study, we utilized AQP3-knockout mice as the in vivo model and AQP3-knockdown human bronchial epithelial cells (HBECs) as the in vitro model. Airway injury was experimentally induced by intra-tracheal injection of naphthalene. HE staining, transmission and scanning electron microscope were performed to evaluate self-healing capacity in vivo.
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- * It finds that patients with moderate to severe asthma have fewer Treg cells and lower levels of interleukin-10 compared to healthy individuals, while Th2 cells and interleukin-4 are higher.
- * The results suggest that an imbalance favoring Th2 cells over Treg cells could contribute to the worsening of asthma symptoms in these patients.
Article Synopsis
- The study explores the role of various CD4(+) T cell subsets (Th1, Th2, Th17, Tregs) in allergic asthma to better understand its causes beyond the traditional Th2 response.
- 22 patients with mild, 17 with moderate to severe asthma, and 20 healthy individuals were analyzed for immune cell proportions and associated cytokine levels.
- Results showed increased Th2 and Th17 cells in asthma patients, with decreased Tregs, indicating an imbalance that may contribute to asthma severity and control, suggesting the importance of Th17 and Tregs in managing allergic asthma.