[Hypouricemic effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma].

Objective: To investigate the effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma on hyperuricemic mice.

Methods: The hyperuricemia was induced by gavage of hypoxanthine and subcutaneous injection of potassium oxonate (model A) or subcutaneous injection of uric acid (model B) in ICR male mice. The mice in ethanol extracts groups were administrated with Dioscoreae Nipponicae Rhizoma ethanol extracts 5.

[Protective effect of Jiangbaiweiyan tablet on ethanol-induced gastric mucosa injury in rats].

Objective: To investigate the effect of Jiangbaiweiyan tablet, a Chinese medicine compound composed of Alpinta Officinarum, Cyperus Rotundus, Bulbus Lilii and Rlindera Strychnifolia, on ethanol-induced gastric mucosa injury in rats.

Methods: Acute gastric ulcer was induced in rats with absolute ethyl alcohol. The ulcer index was used to evaluate the extent of the gastric mucosa injury.

Predicting blood-brain barrier penetration from molecular weight and number of polar atoms.

A simple three-descriptor model to predict blood-brain barrier is derived from a training set of 78 compounds: logBB=-9.880 x 10(-6)M(W)(2)+7.339 x 10(-3)M(W)-0.