Time Efficiency of Immediate Loading of Full-arch Implant Reconstructions Using Prefabricated Prostheses Located by an Anchor Pin: a Pilot Study.

Objective: To investigate the time efficiency of prefabricated prostheses located by an anchor pin stereolithographic attachment system for immediate loading implant reconstruction of completely edentulous jaws and compare it with the conventional protocol.

Methods: Edentulous patients were recruited and randomly assigned into two groups: the full digital workflow group (digital group) and the conventional workflow group (conventional group). In the digital group, a provisional prosthesis was fabricated before surgery using a fully digital workflow and delivered immediately after implant placement.

Occlusal Rehabilitation in a Patient with Oligodontia and Microdontia using Implants and Full-Ceramic Restorations: A Clinical Report.

Oligodontia is the agenesis of six or more permanent teeth, excluding the third molars. Multidisciplinary dental treatments should be performed sequentially due to the restoration requirements for good oral function, aesthetics and self-confidence of patients. In this study, we report a case using dental implants and full-ceramic prostheses to restore the absent and malformed teeth in a patient with agenesis of 18 permanent teeth and with some primary teeth retained.

Association between EDAR Polymorphisms and Non-Syndromic Tooth Agenesis in the Chinese Han Population.

Objective: To explore the relationship between single nuclear polymorphisms (SNPs) in ectodysplasin A receptor (EDAR) and EDAR-associated death domain (EDARADD) genes and non-syndromic tooth agenesis.

Methods: Ten putative SNPs in EDAR and EDARADD were selected, and a case-control study was conducted in 112 subjects with non-syndromic tooth agenesis and 112 normal control subjects. DNA was obtained from peripheral blood samples.

Simultaneous Occurence of an Autosomal Dominant Inherited MSX1 Mutation and an X-linked Recessive Inherited EDA Mutation in One Chinese Family with Non-syndromic Oligodontia.

Objective: To describe the simultaneous occurence of an autosomal dominant inherited MSX1 mutation and an X-linked recessive inherited EDA mutation in one Chinese family with nonsyndromic oligodontia.

Methods: Clinical data of characteristics of tooth agenesis were collected. MSX1 and EDA gene mutations were detected in a Chinese family of non-syndromic oligodontia.

Prosthodontic Treatment for Severe Oligodontia with Long-term Follow-up.

Objective: To express the early prosthodontic treatment strategies for severe oligodontia patients with or without a syndrome and to share details of their experiences of the long-term follow-up.

Methods: Patients with severe oligodontia (excluding the third molars, and with six or more congenitally missing permanent teeth) who had finished prosthetic rehabilitation between 2001 and 2014 and who had undergone at least 1-year follow-up at the Department of Prosthodontics, Peking University School of Stomatology were included in the study. The general and oral characteristics were determined and examined, interdisciplinary plans were provided, and the prosthodontic treatment conditions were described and evaluated.

Prevalence of tooth agenesis in adolescent Chinese populations with or without orthodontics.

Objective: To determine the prevalence of hypodontia in the general population and orthodontic population in adolescent Chinese Hans.

Methods: Two groups named the general population (6015 subjects) and the orthodontic population (2781 subjects) were investigated, respectively. The former came from the students of three general universities in North China and the latter came from patients coming to the Department of Orthodontics, Peking University School and Hospital of Stomatology for orthodontic consulting during the summer and winter holidays in 2008.

[Precision of digital impressions with TRIOS under simulated intraoral impression taking conditions].

Objective: To evaluate the precision of digital impressions taken under simulated clinical impression taking conditions with TRIOS and to compare with the precision of extraoral digitalizations.

Methods: Six #14-#17 epoxy resin dentitions with extracted #16 tooth preparations embedded were made. For each artificial dentition, (1)a silicone rubber impression was taken with individual tray, poured with type IV plaster,and digitalized with 3Shape D700 model scanner for 10 times; (2) fastened to a dental simulator, 10 digital impressions for each were taken with 3Shape TRIOS intraoral scanner.

A novel non-stop mutation in MSX1 causing autosomal dominant non-syndromic oligodontia.

Oligodontia, which is the congenital absence of six or more permanent teeth, excluding the third molars, may contribute to masticatory dysfunction, speech alteration, aesthetic problems and malocclusion. Msh homeobox 1 (MSX1) was the first gene identified as causing non-syndromic oligodontia. In this study, we identified a novel heterozygous non-stop mutation (c.

[Effects of wearing dentures on sleep breathing among edentulous people: a preliminary study].

Objective: To investigate the effects of wearing dentures on sleep breathing among edentulous people.

Methods: Nine edentulous people were recruited to participate in this selfcontrolled case series clinical study. Polysomnogram (PSG) was carried out on two consecutive nights, on one night the patients slept wearing dentures, and on the other without dentures.

[Association between AXIN2 polymorphism and oligodontia].

Objective: To explore the association between AXIN2 polymorphism and oligodontia in Chinese population.

Methods: We employed 97 individuals diagnosed with sporadic non-syndromic oligodontia and 200 healthy control subjects. Their DNA was obtained from the whole blood or buccul swap samples and the genotyping was performed by polymerase chain reaction (PCR).

[Fracture reliability of zirconia all-ceramic crown according to zirconia coping design].

Objective: To study the fracture resistance and characteristics of the bi-layer zirconia all ceramic crowns according to the zirconia coping design using various experimental methods and to compare the results of the in vitro test with the clinical evaluation.

Methods: The bi-layer zirconia all ceramic crowns were fabricated by the same method as used in clinical practice. Two different coping designs with/without zirconia marginal collar were used.

A review of the bioactivity of hydraulic calcium silicate cements.

Objectives: In tissue regeneration research, the term "bioactivity" was initially used to describe the resistance to removal of a biomaterial from host tissues after intraosseous implantation. Hydraulic calcium silicate cements (HCSCs) are putatively accepted as bioactive materials, as exemplified by the increasing number of publications reporting that these cements produce an apatite-rich surface layer after they contact simulated body fluids.

Methods: In this review, the same definitions employed for establishing in vitro and in vivo bioactivity in glass-ceramics, and the proposed mechanisms involved in these phenomena are used as blueprints for investigating whether HCSCs are bioactive.

[Effect of early-loaded small diameter implants retained mandibular overdentures on masticatory performance].

Objective: To evaluate the clinical effect and masticatory efficiency of two early loaded Small Diameter Implants (SDI) retained mandibular overdentures.

Methods: Eight mandibular edentulous patients received two SDIs insertion between mental foramina. The mandibular overdentures were connected with implants for early loading in the period of 2-4 weeks following implant insertion.

[Esthetic evaluation of Cerec 3D anterior crowns].

Objective: To observe the short-term effect of clinical application of Cerec 3D anterior crowns.

Methods: A total of 16 patients were restored with 31 Cerec 3D anterior crowns. All restorations were stained before cementation.

[Short-term clinical observation of modified resin-bonded fixed partial denture utilizing tooth undercuts].

Objective: To observe a short-term clinical result of modified resin-bonded fixed partial denture(MRBFPD) utilizing tooth undercuts.

Methods: One hundred and twenty-nine patients received restoration and totally 196 missing teeth were restored with 148 MRBFPD. According to the positions of abutments in the dental arch, all the MRBFPD were divided into three groups, namely anterior prostheses (40), posterior prostheses (95) and prostheses spanning anterior and posterior (13).

[Adoption of the condyle position of patients with extensive tooth wear during occlusal rehabilitation].

Objective: To evaluate the adoption of the condyle position of patients with extensive tooth wear during occlusal rehabilitation, and the correlation between increased vertical dimensions and the changes of joint spaces.

Methods: Twenty-seven patients (five from Beifang hospital, others from Peking University School and Hospital of Stomatology) with extensive tooth wear were selected and received occlusal rehabilitation treatment. The radiographs of standard Schüllers position were taken before treatment (stage 1), 1 month following delivery of temporary restoration (stage 2), and 1 month following delivery of permanent restoration (stage 3).

[Inhibition of retinoblastoma binding protein 2 promotes osteogenic differentiation of human adipose-derived stromal cells].

Objective: To explore the effect of retinoblastoma binding protein 2 (RBP-2), a histone H3K4 demethylase, on osteogenic differentiation of human adipose-derived stromal cell (hASC).

Methods: According to the GenBank sequence information of RBP-2, four different small interfering RNAs (siRNA) targeting RBP-2 gene were designed and the corresponding short hairpin RNAs (shRNA) were cloned into pLL 3.7 lentivirus RNA interference vector.

[Influence of experimental palatal plate on mandibular position during continuous [n] phonation in complete denture wearers].

Objective: To clarify the influence of an experimental palatal plate on the mandibular position during continuous [n] phonation and at the physiological rest position in complete denture wearers.

Methods: Ten complete denture wears volunteers were investigated. Two kinds of experimental palatal plate with a thickness of 3 mm and 5 mm (from the denture basal surface to denture polished surface) were fabricated and used for each subject.

[Heterozygous TP63 mutation in a Chinese patient with ectrodactyly-ectodermal dysplasia clefting syndrome without clefting].

Objective: To determine if alteration in TP63 is responsible for a Chinese patient with ectrodactyly-ectodermal dysplasia clefting (EEC) syndrome, but without cleft palate/lip.

Methods: Screening of TP63 gene was performed in the patient with EEC syndrome and his family members using PCR-single strand conformational polymorphism (SSCP) analysis, then performed by direct sequencing of the coding region.

Results: A C > T substitution at nucleotide position 838 in exon 7 was detected in the patient, and the change predicted a heterozygous missense mutation, Arg280Cys.

[Double scanning method for computer aided design and computer aided manufacture all-ceramic restorations].

Objective: To introduce the double scanning for producing computer aided design and computer aided manufacture (CAD-CAM) zirconia crowns, and to compare Procera with Everest CAD-CAM system by observing clinical effects of the crowns.

Methods: Forty CAD-CAM zirconia crowns (10 crowns by Procera, and 30 crowns by Everest) were evaluated, and the examination criteria included: marginal fit, aesthetics, gingival health, retention, and fracture. All of the zirconia copings were produced using double scanning.

[The accuracy of occlusal simulation of virtual craniofacial movement simulation system].

Objective: To evaluate the accuracy of occlusal contacts simulated by virtual craniofacial movement simulation system, and to provide theoretical basis for its application.

Methods: Ten pairs of plaster dental casts were fabricated, and mounted on Kavo PROTA 7 articulator. Lateral movement was produced on the articulator.

[Clinical application of computer-aided design and rapid prototyping technique for radioactive seeds contained maxillary device].

Objective: To test a new method to manufacture a maxillary applicator containing radioactive seeds for brachytherapy of malignant neoplasms based on computer aided design (CAD) and rapid prototyping (RP).

Methods: Six patients with maxillary malignancy which had eroded the inferior wall of orbit and skull base were included in this study. After excision of the tumors, head CT data of these patients were transmitted into the computer.