Publications by authors named "Hai-jun Huang"
Article Synopsis
- - The study focused on understanding the sex determination mechanisms in a species with sexual dimorphism and similar chromosome pairs, aiming to clarify its sex chromosome for insights into sex chromosome evolution in Pleuronectiformes.
- - Whole-genome resequencing revealed Chr23 as the sex chromosome with a significant sex-determining region (SDR) indicating an XX/XY system, and no inversions were found in the SDR but chromosomal rearrangements were noted.
- - A sex-specific genetic marker was identified, which could enhance breeding programs and practices in aquaculture by allowing for accurate genetic sex identification.
Article Synopsis
- * A new forecasting method is developed to track the early stages of traffic jams, focusing on their growth and eventual dissipation based on real urban traffic-speed data.
- * Findings reveal that traffic jams typically dissolve slower than they grow, and early growth rates are key indicators of their potential maximum size, enabling improved traffic control strategies.
Article Synopsis
- Humeral fractures are common in orthopedic practice, and this study aims to understand how metal bone nails affect temperature changes during MRI scans.
- Using a detailed geometric model and COMSOL simulations, researchers found that the specific absorption ratio (SAR) and temperature near the bone-nail implants significantly increased post-surgery.
- The study concludes that metal implants can raise local SAR levels during MRI, leading to potential risks of overheating and damage to surrounding tissues with prolonged scans.
Article Synopsis
- Malignant ventricular arrhythmias (VA) following a myocardial infarction (MI) are linked to changes in heart electrical properties, and BRG1 plays a key role in this remodeling process.* -
- The study involved creating a mouse model of MI and using various techniques, including ECG monitoring and optical voltage mapping, to analyze the effects of BRG1 on ion channel behavior and cardiac function.* -
- Findings reveal that increased BRG1 expression after MI worsens the heart's electrical stability, while knocking down BRG1 improves conduction speed and heart rhythm, suggesting its potential as a therapeutic target for arrhythmias post-MI.*
Article Synopsis
- PFI-3 is a newly developed small-molecule inhibitor that selectively targets BRGs, showing potential as a therapeutic agent, though its effects on vascular function needed investigation.
- In experiments using a microvascular tension measurement device and fluorescence techniques, PFI-3 was found to cause relaxation in rat mesenteric arteries in response to various constrictors, without being influenced by certain blockers.
- The results indicated that PFI-3 reduces calcium influx and the activity of L-type voltage-dependent calcium channels in arterial smooth muscle cells, contributing to its vasodilatory effects.
The objective of this study was to evaluate the fertilization capability of White Bengal Tiger frozen-thawed completely immotile spermatozoa after interspecific intracytoplasmic sperm injection (ICSI) with bovine oocytes. The fertilization status of presumptive zygotes was assessed 18 h after ICSI by immunofluorescence staining and confocal microscopy. The fertilization rate was 34.
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- Recently, nonalcoholic fatty liver disease (NAFLD) has been rebranded as metabolic-associated fatty liver disease (MAFLD), excluding certain non-obese individuals from its definition.
- The study analyzed the histological differences between MAFLD and non-MAFLD groups in biopsy-proven NAFLD patients, focusing on metabolic dysfunction indicators.
- Results showed that MAFLD patients had a greater NAFLD activity score and more severe hepatic steatosis compared to non-MAFLD patients, while no significant differences in other histological features were found between the groups.
Article Synopsis
- * Fifty-two patients were divided into two groups: one underwent single-incision surgeries while the other had double-plate surgeries, with outcomes analyzed for effectiveness.
- * Results indicated that surgery is best performed 6-8 days after injury, with the double-plate method showing superior healing, especially in younger and male patients, leading to an over 80% recovery rate by five months.
Article Synopsis
- * The model evaluated data from 914 suspected COVID-19 pneumonia cases, assessing variables like epidemiological features, clinical symptoms, and imaging results.
- * Results showed the model had a high accuracy of 87%, a sensitivity of 83.82%, and specificity of 89.57%, indicating its effectiveness for early detection and treatment of COVID-19 pneumonia.
Article Synopsis
- Primary bone lymphoma (PBL) is a rare type of lymphoma, constituting about 1%-3% of cases, with ALK-positive anaplastic large-cell lymphoma (ALCL) being an extremely rare form.
- A case study detailed a 66-year-old man with neck and shoulder pain, fever, and a confirmed diagnosis of primary bone ALK-positive ALCL following imaging and biopsy that showed neoplastic cells.
- The patient responded partially to chemotherapy and the report emphasizes the need for physicians to consider lymphoma in cases of isolated bone lesions, as these can sometimes present without lymph node involvement.
Article Synopsis
- The study addresses the challenge of creating metal nanoparticle-based strain sensors that maintain good linearity and a wide operation range while dealing with defects from large strain.
- Researchers developed a novel strain sensor using a special liquid metal-like Ag NP ink, which boasts remarkable stretchability (up to 800%) and self-healing properties through 3D printing.
- The sensor demonstrated impressive conductivity and long-term stability, making it suitable for applications such as monitoring human knuckle movement due to its continuous conductive networks formed by unique interactions between the Ag NPs and surrounding materials.
Article Synopsis
- The study aimed to create a fast screening model to early detect novel coronavirus pneumonia (NCP) in a population from Zhejiang, China.
- It involved 880 individuals suspected of having NCP and utilized various predictors like epidemiological data, clinical signs, and lab results, achieving a high accuracy of 0.920.
- The developed models showed strong sensitivity and specificity, proving to be practical and cost-effective tools for predicting NCP early, especially amid a widespread outbreak.
Article Synopsis
- * This article discusses a case of a 20-year-old man with fungal pneumonia who developed severe air embolism in multiple areas, including the heart and major arteries, after receiving intensive care treatment.
- * The patient ultimately died from multiple organ dysfunction, highlighting the need for immediate intervention, such as hyperbaric oxygen therapy, in cases of vascular air embolism during mechanical ventilation.
Article Synopsis
- Atherosclerosis (AS) is a chronic inflammatory disease involving lipid buildup in arteries, with macrophages playing a key role in its progression.
- This study used AS mouse models to examine how altering microRNA-133b (miR-133b) and inhibiting the Notch-signaling pathway affects macrophage behavior related to plaque formation and vascular changes.
- Results showed that downregulating miR-133b or blocking the Notch pathway led to less plaque buildup, fewer active macrophages, and more vascular smooth muscle cells, suggesting miR-133b as a potential new target for treating AS.
The concept of resilience can be realized in natural and engineering systems, representing the ability of a system to adapt and recover from various disturbances. Although resilience is a critical property needed for understanding and managing the risks and collapses of transportation systems, an accepted and useful definition of resilience for urban traffic as well as its statistical property under perturbations are still missing. Here, we define city traffic resilience based on the spatiotemporal clusters of congestion in real traffic and find that the resilience follows a scale-free distribution in 2D city road networks and 1D highways with different exponents but similar exponents on different days and in different cities.
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- * The study analyzed the proteomic profiles of CHB patients with different levels of liver fibrosis to identify potential serum biomarkers for detecting the critical S2 stage, involving 90 CHB patients and additional validation groups.
- * A total of 139 proteins showed significant expression differences across fibrotic stages, with five candidates identified as promising biomarkers, particularly ficolin-2 (FCN2) and carboxypeptidase B2 (CPB2), which require further investigation for their
Article Synopsis
- Tuberculous meningitis (TBM) is a severe infection of the brain's protective membranes, with high rates of illness and death, making it difficult to diagnose against other meningitis types.
- Researchers conducted a study analyzing cerebrospinal fluid (CSF) samples from patients with TBM and other types of meningitis using advanced mass spectrometry to identify unique metabolites.
- The analysis revealed distinct metabolic profiles between TBM and other meningitis forms, uncovering potential biomarkers for better differentiation and diagnosis of TBM.
Article Synopsis
- Tuberculous meningitis (TBM) is a severe form of central nervous system tuberculosis with a notably poor prognosis, primarily assessed by the Glasgow Outcome Scale at discharge.
- A study of 45 TBM patients revealed that 77.8% had a good prognosis, while 22.2% faced a poor prognosis, with key factors such as old age, disturbed consciousness, and hydrocephalus linked to worse outcomes.
- Multivariate analysis identified old age and hydrocephalus as significant independent predictors of poor prognosis, highlighting the need for timely and special care for affected patients.
Article Synopsis
- Peliosis hepatis (PH) is a rare liver condition that features blood-filled cavities, making it difficult to distinguish from other types of liver lesions during imaging.
- The report discusses two cases where patients showed liver lesions on ultrasound and CT scans, without any previous liver issues or drug use.
- Diagnosing PH involved liver biopsy and laparoscopy, revealing sinusoidal dilatations, and both patients showed good recovery after follow-up for a year.
Novosphingobium profundi sp. nov. isolated from a deep-sea seamount.
Antonie Van Leeuwenhoek
January 2017
Article Synopsis
- - A new marine bacterial strain, labeled F72, was discovered from a solitary coral in the Pacific Ocean, and it's identified as a Gram-negative, motile, rod-shaped bacterium related to the genus Novosphingobium.
- - Phylogenetic analysis revealed that strain F72 shares high genetic similarities (around 97%) with several other Novosphingobium species, and it has specific fatty acids, quinones, and a G+C content of 63.4 mol%.
- - Based on various studies, strain F72 was proposed as a new species within the Novosphingobium genus, named Novosphingobium profundi sp. nov., with designated type strain F72.
Pseudoalteromonas profundi sp. nov., isolated from a deep-sea seamount.
Int J Syst Evol Microbiol
November 2016
Article Synopsis
- A new bacterial strain, designated TP162T, was isolated from the Yap Trench in the tropical western Pacific, characterized as Gram-stain-negative, rod-shaped, strictly aerobic, and motile.
- Phylogenetic analysis revealed that TP162T is closely related to the Pseudoalteromonas genus, with the highest similarity to P. shioyasakiensis, at 98.2% based on 16S rRNA gene sequences.
- Comprehensive studies indicate that TP162T represents a new species within the Pseudoalteromonas genus, which is proposed to be named Pseudoalteromonas profundi sp. nov.
Oceanihabitans sediminis gen. nov., sp. nov., a member of the family Flavobacteriaceae isolated from the Yellow Sea.
Int J Syst Evol Microbiol
September 2016
Article Synopsis
- A new Gram-stain-negative bacterial strain called S9-10T was discovered in sediment from the Yellow Sea near China, belonging to the Flavobacteriaceae family.
- Genetic analysis identified S9-10T as a unique lineage with a G+C content of 34.2 mol%, and showed it has specific fatty acids and lipid profiles.
- Based on various scientific analyses, this strain is proposed as a new species and genus, named Oceanihabitans sediminis, with its type strain designated as S9-10T.
Winogradskyella sediminis sp. nov., isolated from marine sediment.
Int J Syst Evol Microbiol
August 2016
Article Synopsis
- A new bacterial strain, S5-23-3T, was discovered in sediment from the Yellow Sea, China, and is characterized as Gram-stain-negative, rod-shaped, and yellow-pigmented.
- Phylogenetic analysis indicated that S5-23-3T is closely related to the genus Winogradskyella, sharing significant genetic similarity with several known species.
- The study also detailed S5-23-3T’s unique fatty acid composition and lipid profiles, leading to its classification as a new species, Winogradskyellasediminis sp. nov.
Aim: To assess the efficacy of tenofovir disoproxil fumarate (TDF) in lamivudine (LAM)-resistant patients with a suboptimal response to LAM plus adefovir (ADV).
Methods: We retrospectively analyzed the efficacy of switching to tenofovir disoproxil fumarate in suboptimal responders to lamivudine plus adefovir. Charts were reviewed for LAM-resistant chronic hepatitis B (CHB) patients who visited the Zhejiang Province People's Hospital and The First Affiliated Hospital, College of Medicine, Zhejiang University, from June 2009 to May 2013.
Article Synopsis
- The use of gene expression markers like EGFP has been important for selecting mammalian cell clones that produce high levels of recombinant proteins, but more cost-effective methods are still needed.
- A new method is introduced that co-expresses EGFP and a target protein linked by an internal ribosome entry site, enabling efficient clonal selection in standard 96-well plates.
- This technique was tested by expressing recombinant porcine β-defensin 1 in Marc 145 cells, showing its effectiveness as an alternative to traditional cell sorting methods for identifying high-producer clones.