Publications by authors named "Hai-jie Duan"
Objective: To investigate the effects of Bai-Chuan capsule (BC) on the left ventricular hypertrophy in spontaneously hypertensive rats (SHR).
Methods: Taking SHR and Wistar Kyoto rats (WKY) as the model group and the control group respectively, Captopril as positive drug, administered BC 0.3 g/kg, Captopril 3.
Article Synopsis
- Store-operated Ca(2+) entry (SOCE) is thought to play a role in calcium influx in vascular smooth muscle cells, and the study explored how this relates to the vasodilatory effects of imperatorin, a dietary compound.
- The researchers conducted experiments on rat mesenteric arteries and VSMCs, using both measurement of isometric tension and confocal microscopy to assess calcium levels.
- Despite imperatorin causing vasodilation, the study found that it does not inhibit SOCE-induced calcium increases or contractions, suggesting that the vasodilation effect is not due to the SOCE mechanism, and it shares similarities with the effects of nifedipine.