Publications by authors named "Hai-hong Zhuge"
[Expression of Toll-like receptor 2/4 mRNA in myocardium in mice with hemorrhagic shock].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
September 2006
Article Synopsis
- The study aimed to assess how hemorrhagic shock without resuscitation affects Toll-like receptor (TLR) expression in the heart of rats, highlighting its significance.
- Forty-five mice were divided into three groups, with the hemorrhagic shock model created via heart puncture; TLR2 and TLR4 expression levels were measured, and heart function was evaluated through left ventricular pressure.
- Results showed that both hemorrhagic shock and lipopolysaccharide (LPS) reduced blood pressure and heart function, while increasing TLR2 and TLR4 expression in the heart, indicating a link between these receptors and cardiac dysfunction in shock conditions.