Publications by authors named "Hai-chen Yang"
Article Synopsis
- A study of 555 bipolar disorder (BD) patients in China examined differences between those with psychotic symptoms (BD P +) and those without (BD P-).
- Findings indicated that BD P + patients were more likely to have a BD I diagnosis, experience mania or mixed episodes, and be misdiagnosed as schizophrenia, rather than major depressive disorder.
- Multivariate analyses showed that BD P + patients had higher rates of hospitalizations and suicidal behaviors, used more antipsychotics and mood stabilizers, but less frequently used antidepressants compared to BD P- patients.
Objective: To investigate the prevalence of psychotic depression and the differences in sociodemographic and clinical characteristics and prescription patterns of psychotropic medications between patients with psychotic depression (PD) and patients with nonpsychotic depression (NPD) in China.
Methods: We conducted a cross-sectional study in 13 major psychiatric hospitals or the psychiatric units of general hospitals in China from September 1, 2010, to February 28, 2011. PD was defined according to the psychotic disorder section of the Mini International Neuropsychiatric Interview (MINI).
A study on attentional bias and response inhibition of facial expressions in manic patients: evidence from eye movement.
Int J Psychiatry Clin Pract
September 2019
In recent years, evidence has accumulated to suggest that patients with bipolar disorder show altered processing of emotionally relevant information. However, only a few studies have examined manic patients' eye movements when processing facial expressions. A free viewing task and anti-saccade task were used separately to investigate attentional bias and response inhibition while processing emotional stimuli.
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- This study examined the prevalence and characteristics of atypical depression among major depressive disorder (MDD) patients in China, finding that 15.3% of patients had atypical features.
- Atypical depression patients were more likely to experience severe symptoms, such as suicidal ideation, psychotic features, and seasonal episodes, and generally had an earlier onset of depression.
- The study's limitation includes not using a validated scale to assess atypical features, but it highlights that atypical depression may be more severe and impactful in Chinese MDD patients.
Article Synopsis
- - The study explored the differences in demographic and clinical characteristics between patients with short (≤2 years) and long (>2 years) duration of untreated bipolar disorder (DUB) among 555 Chinese patients across various hospitals.
- - Findings indicated that 31% of patients had a long DUB, and factors like a longer illness duration, diagnosis of bipolar disorder type II, and earlier misdiagnosis of other mental disorders were linked to long DUB.
- - The average DUB in Chinese patients was found to be shorter compared to figures from Western countries, highlighting the need for further research on the long-term effects of DUB on bipolar disorder outcomes.
Article Synopsis
- - A study in China analyzed 555 bipolar disorder patients to compare demographic and clinical features between early-onset bipolar disorder (EOB) in patients aged 21 and younger and late-onset bipolar disorder (LOB) in patients older than 21.
- - Results indicated that EOB patients were more likely to be older, unemployed, have a longer illness duration, and had a higher tendency for misdiagnosis as schizophrenia, whereas LOB patients were less likely to be incorrectly diagnosed as major depressive disorder.
- - The findings suggest that EOB is linked to poorer outcomes and the clinical differences are similar to those found in Western countries, highlighting the need for further prospective studies on long-term outcomes related to age at onset.
Article Synopsis
- This study investigated the prevalence and characteristics of comorbid dysthymia in Chinese patients with major depressive disorder (MDD), finding that 8.7% of MDD patients also met the criteria for dysthymia.
- It revealed that patients with both MDD and dysthymia exhibited distinct clinical features, such as more depressive episodes with atypical symptoms and fewer psychiatric family histories.
- The research concluded that the differences observed in this demographic could influence treatment strategies, even though the prescription patterns for psychotropic medications were similar between the two patient groups.
Risk Factors for Anxiety in Major Depressive Disorder Patients.
Clin Psychopharmacol Neurosci
December 2015
Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD).
Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively.
Background: Little is known about the demographic and clinical differences between early- and late-onset depressions (EOD and LOD, respectively) in Chinese patients. This study examined the demographic and clinical profile of EOD (<=25 years) compared to LOD (>25 years) in China.
Methods: A consecutively recruited sample of 1178 patients with MDD was assessed in 13 psychiatric hospitals or psychiatric units of general hospitals in China nationwide.
Background: The aim of this study was to test the ability of the Chinese version of the Mood Disorder Questionnaire (MDQ) to identify Bipolar Disorders (BD) in patients diagnosed with Major Depressive Disorder (MDD) or Unipolar Disorder (UD) in the clinical setting.
Methods: 1,487 being treated for MDD or UD at 12 mental health centers across China, completed the MDQ and subsequently examined by the Mini International Neuropsychiatric Interview (MINI). Receiver Operating Characteristic(ROC) curves were used to determine the ability of the MDQ to differentiate between BD (BD, BD-I and BD-II) and MDD or UD and patients with BD-I from patients with BD-II.
Article Synopsis
- The study investigated cigarette smoking prevalence among Chinese schizophrenia inpatients on antipsychotic mono-therapy, finding a 40.6% smoking rate, with significant differences between genders (57.5% in males vs. 6.3% in females).
- About 66.9% of participants were male, and various clinical and socio-demographic factors were analyzed to understand their correlation with smoking habits.
- Results showed that smoking rates among these patients were not significantly higher than the general population; however, more severe symptoms and other factors were linked to higher smoking prevalence.
Article Synopsis
- The study investigates gender differences in major depressive disorder (MDD) among Chinese patients, focusing on demographics, clinical characteristics, and psychotropic treatment.
- Among the 1,178 patients analyzed, key findings indicate that male patients are generally younger and have fewer lifetime depressive episodes, while females are more affected by stressful life events.
- Results suggest that gender-related differences in MDD may vary significantly between Chinese patients and those in Western studies, hinting at the influence of cultural and biological factors on depression.
Background: White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD.
View Article and Find Full Text PDFObjectives: Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD), which may lead to inappropriate treatment and poor outcomes. This study aimed to compare demographic and clinical features between patients with MDD and those with BD, but being misdiagnosed as MDD, in China.
Methods: A total of 1487 patients diagnosed with MDD were consecutively evaluated in 13 psychiatric hospitals or psychiatric units of general hospitals nationwide in China.
Objective: Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD), which may lead to inappropriate treatment and poor outcomes. This study aimed to examine prescribing patterns of antidepressants, antipsychotics and mood stabilizers in BD patients misdiagnosed with MDD in China.
Methods: A total of 1487 patients originally diagnosed with MDD were consecutively screened for diagnostic revision in 13 psychiatric hospitals or psychiatric units of general hospitals in China nationwide.
Aim: To investigate the results of the Hypomania Checklist-32 (HCL-32) administered as a screening instrument in clinical settings to mood disorders patients in the depressive phase.
Methods: A total of 1487 patients diagnosed and being treated for major depressive disorder (MDD) in 13 mental health centers across China were self-rated by the HCL-32 and independently examined by the Mini International Neuropsychiatric Interview (MINI).
Results: After examination by the MINI, 309 (20.
Background: Little has been known about the demographic and clinical features of the melancholic subtype of major depressive disorder (MDD) in Chinese patients. This study examined the frequency of melancholia in Chinese MDD patients and explored its demographic and clinical correlates and prescribing patterns of psychotropic drugs.
Methods: A consecutively collected sample of 1,178 patients with MDD were examined in 13 psychiatric hospitals or psychiatric units of general hospitals in China nationwide.
Background: Bipolar disorder (BD) is often misdiagnosed as a major depressive disorder (MDD). This study aimed to test the usefulness of the screening tool, the Mood Disorders Questionnaire (MDQ), to identify BD patients misdiagnosed as MDD in Chinese clinical settings.
Methods: A total of 1487 patients treated for MDD were consecutively examined in 13 mental health centers in China.
Background: Bipolar disorder (BD) is a recurrent, complex illness and often misdiagnosed and treated as a major depressive disorder (MDD). This study set out (1) to investigate the proportion of BD in patients treated for MDD using DSM-IV diagnostic criteria; (2) to test the usefulness of the screening tool - the 32-item Hypomania Checklist (HCL-32) in Chinese patients; and (3) to assess whether MDD patients with subthreshold manic features (patients who screened positive for BD on the HCL-32, but did not meet the diagnostic criteria for DSM-IV BD as measured by Mini International Neuropsychiatric Interview (MINI)) differ from those with BD, and from those suffering from MDD without manic features in terms of basic demographic and clinical variables.
Methods: A total of 1487 patients treated for MDD were consecutively examined in 13 mental health centers in China.
Background: The 32-item Hypomania Checklist (HCL-32), a questionnaire for screening bipolar disorders, has been utilised in several countries, but it unclear if the Chinese version of the HCL-32 is valid.
Methods: Consecutive patients with bipolar disorders (BP, N = 300) and unipolar major depression (UP, N = 156) completed the Chinese version of the HCL-32. The subjects underwent a structured clinical interview for DSM-IV Axis-I disorders (SCID).
To investigate the validity of the Chinese version of Mood Disorder Questionnaire (C-MDQ) in China. Patients with bipolar disorders (BP, N=284) and patients with unipolar depressive disorder (UP, N=134) were assessed with the C-MDQ. The Eigenvalues of the first two factors were 3.
View Article and Find Full Text PDFStudies have previously documented that microRNAs (miRNAs), with their key roles in regulating both synaptic plasticity and brain development, are candidate genetic contributors to the etiopathology of bipolar disorder (BD). Moreover, miRNA identified as targets for the actions of chronic lithium and VPA are known to play diverse and intriguing roles in brain function. In particular, the brain specific miR-134 has recently been identified as a potential regulator of dendritic spine volume and synapse formation.
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