macrophages promote hepatocellular carcinoma tumor stemness and progression through /β-catenin/ axis.

Liver cancer stem-like cells (LCSCs) are the main cause of heterogeneity and poor prognosis in hepatocellular carcinoma (HCC). In this study, we aimed to explore the origin of LCSCs and the role of the TOP2A/β-catenin/YAP1 axis in tumor stemness and progression. Using single-cell RNA-seq analysis, we identified LCSCs, which were mainly regulated by M2-like macrophages.

Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism.

Hypersplenism (HS) is a concomitant symptom of liver or blood disease. Not only does the treatment of HS face challenges, but the transcriptome of individual cells is also unknown. Here, the transcriptional profiles of 43,037 cells from four HS tissues and one control tissue were generated by the single-cell RNA sequencing and nine major cell types, including T-cells, B-cells, NK cells, hematopoietic stem cells, neutrophil cells, mast cells, endothelial cells, erythrocytes, and dendritic cells were identified.

MicroRNA-203-3p inhibits the proliferation, invasion and migration of pancreatic cancer cells by downregulating fibroblast growth factor 2.

Aberrant expression of fibroblast growth factor 2 (FGF2) is a major cause of poor prognosis in patients with pancreatic cancer. MicroRNA (miRNA/miR) miR-203-3p is a newly identified miRNA that can affect the biological behavior of tumors. The present study investigated the function of miR-203-3p on the regulation of FGF2 expression, and its role in pancreatic cancer cell proliferation, apoptosis, invasion and migration.

The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine.

Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors.

Electroacupuncture Modulates Resting-State Functional Connectivity in the Default Mode Network for Healthy Older Adults.

Aging involves cognitive decline and prominent alterations in brain activity. Electroacupuncture (EA), a traditional Chinese medicine approach, is demonstrated to be effective in improving cognitive function of older adults. However, the specific neural mechanism underlying this modulation effect remains unclear.

[Effects and Differences of the Release of Dissolved Organic and Inorganic Phosphorus in Different Sediments Covered by Different Materials of Erhai Lake].

In this work, the effects of four covering materials on the release of total dissolved phosphorus (DTP), dissolved organic phosphorus (DOP), and soluble reactive P (SRP) in different sediments of Erhai Lake were simulated. The results showed that the max release of DTP was reduced in covering material, which attributed to the changes of pH, Eh and characteristics of dissolved organic matter (DOM) by the effect of covering material. The application of iron oxide material significant reduced the release of DTP in the northern and southern part of the lake, with decrease rate of 44.

[Relationship between the DO and the environmental factors of the water body in Lake Erhai].

The contents of DO and nitrogen (N), phosphorus (P), chlorophyll a in water from Lake Erhai were analysed by combining the nitrogen and phosphorus forms in sediment. The results indicated that the DO contents of the water from Lake Erhai varied from 6.61 to 7.

[Effect of different type sediments on transformation of phosphorus forms and growth of Myriophyllum spicatum].

The changes of the different phosphorus (P) forms in sediments, overlying water and the diversity of dry weight and root forms of Myriophyllum spicatum were studied using different type sediments under simulating condition. The characteristic of transformation of P forms and growth of submerged plant Myriophyllum spicatum were illustrated. The results indicated that the P release was promoted by adding the silver sand in sediment, and their P concentrations in the overlying water were increased.

[Phosphate adsorption characteristics onto the sediments from shallow lakes in the middle and lower reaches of the Yangtze River].

Adsorption isotherms and kinetics of phosphate onto the 11 sediments taken from shallow lakes in the middle and lower reaches of the Yangtze River were determined in laboratory, and the effect of physical and chemical properties of the sediments on its phosphate adsorption characteristics was also analyzed. The results indicate that: (1) The process of phosphate adsorption onto sediments mainly occurred within 0-10 h, the maximum adsorption rates occurred within 0-0.5 h, and then attends to a dynamic equilibrium; (2) Between the NAP and its organic matter, CEC, total phosphorus, inorganic phosphorus, organic phosphorus, Fe/Al-phosphorus and total nitrogen have remarkable positive correlation; between the maximum adsorption of phosphate and its CEC, inorganic phosphorus, organic matter and total phosphorus have remarkable negative correlation; between the total maximum adsorption of phosphate and its organic matter, CEC, total phosphorus, inorganic phosphorus, organic phosphorus, Fe/Al-phosphorus and total nitrogen have remarkable positive correlation; (3) As regards water quality of the shallow lakes in the middle and lower reaches of the Yangtze River at present, its sediment exists desorption.