[Mechanism of stress-induced microglial activation in depression and traditional Chinese medicine regulation].

Depression exists with high prevalence and heavy disease burden. Stress events play a key role in the occurrence of depression, but the pathological mechanism has not been fully clarified by reason of the complexity and heterogeneity. In recent years, neuroinflammation as a pathological mechanism of depression has received extensive attention.

Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology.

Background: Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear.

Methods: Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in whole tissue sections of differentiated EGC (gastrectomy specimens, n = 302).

A coma-free super-high resolution optical spectrometer using 44 high dispersion sub-gratings.

Unlike the single grating Czerny-Turner configuration spectrometers, a super-high spectral resolution optical spectrometer with zero coma aberration is first experimentally demonstrated by using a compound integrated diffraction grating module consisting of 44 high dispersion sub-gratings and a two-dimensional backside-illuminated charge-coupled device array photodetector. The demonstrated super-high resolution spectrometer gives 0.005 nm (5 pm) spectral resolution in ultra-violet range and 0.

Strong optical absorption of a metallic film to induce a lensing effect in the visible region.

In this work, the two-dimensional profile of the light transmission through a prism-like metallic film sample of Au was measured at a wavelength of 632.8 nm in the visible intraband transition region to verify that, beyond the possible mechanisms of overcoming the diffraction limit, a strongly nonuniform optical absorption path length of the light traveling in the metal could induce a lensing effect, thereby narrowing the image of an object. A set of prism-like Au samples with different angles was prepared and experimentally investigated.

Ultrahigh-resolution spectrometer based on 19 integrated gratings.

Optical spectrometers play a key role in acquiring rich photonic information in both scientific research and a wide variety of applications. In this work, we present a new spectrometer with an ultrahigh resolution of better than 0.012 nm/pixel in the 170-600 nm spectral region using a grating-integrated module that consists of 19 subgratings without any moving parts.

[Plasmakinetic energy transurethral resection versus transurethral bipolar plasmakinetic enucleation and resection of the prostate in the treatment of BPH with the prostate volume <100 ml].

Objective: To investigate the influence of plasmakinetic energy transurethral resection of the prostate (PKRP) versus that of transurethral bipolar plasmakinetic enucleation and resection of the prostate (PKERP) on the bladder function, sexual function and incidence of complications in BPH patients with the prostate volume <100 ml.

Methods: We randomly assigned 140 BPH patients with the prostate volume <100 ml to receive PKRP (n = 70) or PKERP (n = 70) in our hospital from July 2013 to July 2015. We compared the maximum urinary flow rate (Qmax), residual urine volume (RUV), and the rates of ED and retrograde ejaculation before and after surgery as well as the incidence of postoperative complications between the two groups of patients.

A High-Performance Spectrometer with Two Spectral Channels Sharing the Same BSI-CMOS Detector.

Optical spectrometers play an important role in modern scientific research. In this work, we present a two-channel spectrometer with a pixel resolution of better than 0.1 nm/pixel in the wavelength range of 200 to 950 nm and an acquisition speed of approximately 25 spectra per second.

Reorganized Collagen in the Tumor Microenvironment of Gastric Cancer and Its Association with Prognosis.

Collagen components in the tumor microenvironment substantially influence cancer pathogenesis and progression. Nevertheless, in gastric cancer, collagen status and its prognostic role remain unclear. Using picrosirius red staining and immunohistochemistry, we found that collagen deposition was significantly increased in gastric cancer when compared with non-neoplastic tissues, and in cancer stroma, more immature collagen components were present, suggesting a qualitative change.

High photon-to-heat conversion efficiency in the wavelength region of 250-1200 nm based on a thermoelectric BiTe film structure.

In this work, 4-layered SiO/BiTe/SiO/Cu film structures were designed and fabricated and the optical properties investigated in the wavelength region of 250-1200 nm for their promising applications for direct solar-thermal-electric conversion. A typical 4-layered film sample with the structure SiO (66.6 nm)/BiTe (7.

The prognostic value and pathobiological significance of Glasgow microenvironment score in gastric cancer.

Purpose: To evaluate the prognostic value and pathobiological significance of Glasgow microenvironment score (GMS), a parameter based on tumor stroma percentage and inflammatory cell infiltration, in gastric cancer.

Methods: A total of 225 cases of gastric cancer were histologically reviewed, and GMS was evaluated for each case. The association between GMS and patients' survival was investigated.

Comparison of the Developmental Potential and Clinical Results of In Vivo Matured Oocytes Cryopreserved with Different Vitrification Media.

Background: Oocyte vitrification is widely used throughout the world, but its clinical efficacy is inconsistent and depends on the vitrification media. This study compared the developmental potential and clinical results of in vivo matured oocytes cryopreserved with different vitrification media.

Methods: This retrospective study involved vitrified-warmed oocytes at one in vitro fertilization laboratory.

[Vertical patterns of plant species diversity in the Baishuijiang Nature Reserve: explanation of area, climate and boundary constraint].

The linear regression models and variation partitioning method were used to analyze the relative and pure effects of area, climate, and boundary constraint on altitudinal patterns of plant species diversity in the Baishuijiang Natural Reserve. The results showed that diversities of overall plant species and different group species exhibited humped-shaped patterns and the peaks were below the mid-point of the elevation span. The patterns were shaped by all factors together.

Diameter of involved nerves is a valuable prognostic factor for gastric cancer.

The prognostic role of perineural invasion (PNI) in gastric cancer remains unclear. We hypothesized that the diameter of the tumor-involved nerves might be a useful indicator for prognosis. By labeling nerves and cancer cells in 204 cases of gastric cancer with single or double immunochemistry, we found that 146 cases were PNI positive and that 58 were PNI negative.

Reevaluating significance of perineural invasion in gastric cancer based on double immunohistochemical staining.

Context: In gastric cancer, the significance of perineural invasion remains controversial. Detecting perineural invasion with hematoxylin-eosin staining often leads to misdiagnosis. Labeling nerves by immunohistochemistry greatly assists perineural invasion detection, but it might also be misdiagnosed, because scattered cancer cells are difficult to recognize.

Cytogenetic and molecular identification of small-segment chromosome translocation lines from wheat-rye substitution lines to create wheat germplasm with beneficial traits.

Intergeneric crop plant hybrid lines with small-segment chromosome translocations are very useful in plant genetic research and breeding. In this study, to create small-segment chromosome translocations with beneficial agronomic characters, the progeny of wheat-rye substitution lines 5R/5A and 6R/6A were selected from generations F to F for rye-specific characteristics. A PCR primer and specific simple sequence repeat marker for rye were used in F populations to detect rye chromatin and to amplify a specific chromosome band in six translocation lines (06-6-5, 06-6-6, 06-6-9, 6-26-1, 7-23, and 7-33).

Elective single blastocyst transfer is more suitable for normal responders than for high responders.

Background: Embryo quality and receptivity of the endometrium are two factors that determine the results of in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). There is no consensus of the optimal transfer strategy for normal responders or high responders. The current study aimed to find the optimal transfer strategy for different subgroups of patients.

[Isolation of gastric cancer stem cells based on colony morphology and detection of their sensitivity to 5-fluorouracil].

Objective: To investigate the sensitivity of gastric cancer stem cells (GCSCs) to 5-fluorouracil (5-FU), and to explore the cytological mechanism of drug-resistance of gastric cancer.

Methods: Immunohistochemical staining was employed to examine expression of stem cell marker CD44 and drug-resistance protein thymidylate synthase (TS) in 71 cases with gastric cancer. Based on morphology of cell colonies derived from AGS gastric cell line, colonies consisting of GCSCs were isolated, and expression of CD44 and TS, as well as self-renewal capacity of GCSCs were detected.

Application of image spectrometer to in situ infrared broadband optical monitoring for thin film deposition.

A path-folded infrared image spectrometer with five sub-gratings and five linear-array detectors was applied to a broadband optical monitoring (BOM) system for thin film deposition. Through in situ BOM, we can simultaneously acquire the thickness and refractive index of each layer in real time by fitting the measured spectra, and modify the deposition parameters during deposition process according to the fitting results. An effective data processing method was proposed and applied in the BOM process, and it shortened the data processing time and improved the monitoring efficiency greatly.

Overexpression of p204 leads to abnormal embryos and osteogenesis in zebrafish.

p204, an inteferon-inducible protein, is known to play an important role in modulating cell proliferation, cell cycling, and the differentiation of various tissues, including osteoblasts. In order to determine the role of p204 during development in vivo, the teleost zebrafish (Danio rerio), an established vertebrate model for developmental studies, was employed. p204 cDNA was introduced into zebrafish by microinjection, and p204 was ectopically expressed throughout the whole embryo during the early stages of zebrafish embryogenesis, then its expression gradually decreased, mainly in ventrally located cells and retina capsules.

Quality differences between NILs of wheat variety Long 97-586 possessing HMW-GS 7+8 and 7.

The high molecular weight glutenin subunits (HMW-GS) 7+8 were introduced into the Long 97-586 (1, 7, 2+12) wheat variety (Triticum aestivum) by 5 consecutive backcrosses with biochemical marker-assisted selection. Nearly isogenic lines (NILs) of HMW-GS 7 and 7+8 were obtained, and the NILs were planted in the experimental field at the Crop Breeding Institute of Heilongjiang Academy of Agricultural Science in 2004-2006. The field experiments were designed using the two-column contrast arrangement method with six replicates in 2004-2005 and four replicates in 2006.

Lateral shift effect on the spatial interference of light wave propagating in the single-layered dielectric film.

Under the oblique incidence condition, the multiple reflection of wave packets in a layered film structure will have a lateral shift increasing with the film thickness. In the analysis of the spatial interference with consideration of the lateral shift effect, a set of new analytic formulae to normalize the intensity of the s-and p-polarized wave packet was obtained to reduce the error of the ellipsometry parameters significantly as the optical path difference delta is close to mpi. The principle and method developed in this work also can be applied to other film structures in more general applications.

[Clinical study on effect of yufeng capsule on premonitory symptoms of apoplexy].

Objective: To observe the clinical effect of Yufeng Capsule (YFC), a Chinese herbal preparation with function of clearing Heat-toxin in treating premonitory symptoms of apoplexy in middle and old aged patients.

Methods: One hundred and fourteen patients with premonitory symptoms of apoplexy were treated with YFC and compared with 57 patients treated with Venoruton for control. The changes of clinical symptoms, anti-oxidation capability, blood lipid, blood sugar and hemorrheological parameters were observed.