Thin-film nanocomposite NF membrane with GO on macroporous hollow fiber ceramic substrate for efficient heavy metals removal.

The ceramic membrane has been widely used in the wastewater treatment based on the chemical resistance and superior separation performance. A robust and defect-free thin-film nanocomposite (TFN) nanofiltration (NF) membrane on the macroporous hollow fiber ceramic (HFC) substrate was novelly developed for heavy metals removal. Before interfacial polymerization (IP), the aqueous solution of graphene oxide (GO) grafted with ethylenediamine (EDA) was deposited on the HFC substrate by vacuum filtration.

Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human.

The discovery and optimization of a novel series of GPR142 agonists are described. These led to the identification of compound 21 (LY3325656), which demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. Compound 21 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.

Three-channel capillary NF membrane with PAMAM-MWCNT-embedded inner polyamide skin layer for heavy metals removal.

Nanofiltration (NF) membranes with simultaneous high rejection of divalent cations and anions and high water permeation were designed and fabricated interfacial polymerization (IP) on three-channel capillary ultrafiltration (UF) membranes. MWCNTs-COOH were modified with poly(amidoamine) (PAMAM) and the as-synthesized MWCNTs-PAMAM were embedded into the inner polyamide skin-layer of the NF membranes by incorporating them into a piperazine (PIP) aqueous solution, followed by IP with trimesoyl chloride (TMC). The rigid MWCNTs and the dendrimer PAMAM molecules endow the as-fabricated NF membranes with high porosity and good hydrophilicity.

Template-assisted synthesis of NiCoO nanocages/reduced graphene oxide composites as high-performance electrodes for supercapacitors.

Here we reported a coordinating etching and precipitating method to synthesize a complex binary metal oxides hollow cubic structure. A novel NiCoO/rGO composite with a structure of NiCoO nanocages anchored on layers of reduced graphene oxide (rGO) were synthesized a simple template-assisted method and the electrochemical performance was investigated by cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy tests as a faradaic electrode for supercapacitors at a graphene weight ratio of 1 wt% (1%). When used as electrode materials for electrochemical capacitors, the NiCoO/rGO composites achieved a specific capacity of 1375 F g at the current density of 1 A g and maintained 742 F g at 10 A g.

CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma.

Background/aims: This study aims to investigate the effect of CD47 on the development of laryngeal squamous cell carcinoma (LSCC) and the therapeutic potential of monoclonal antibody against CD47 and its ligand SIRPα in the treatment of LSCC.

Methods: We firstly detected the expressions of CD47 mRNA and protein in LSCC and para-carcinoma tissues, introduced the most efficient CD47siRNA sequence into LSCC cells by lentiviral transfection and employed three monoclonal antibodies to evaluate their anti-LSCC effects in vitro and in vivo.

Results: We observed that the mRNA and protein expressions of CD47 in LSCC tissue had significant increase in LSCC tissues compared with those in para-carcinoma tissue (p < 0.

Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.

Aim: Ca(2+)-release-activated Ca(2+) (CRAC) channel, a subfamily of store-operated channels, is formed by calcium release-activated calcium modulator 1 (ORAI1), and gated by stromal interaction molecule 1 (STIM1). CRAC channel may be a novel target for the treatment of immune disorders and allergy. The aim of this study was to identify novel small molecule CRAC channel inhibitors.

[Sources and spatial distribution of typical heavy metal pollutants in soils in Xihu Scenic Area].

Due to the importance as a famous scenic area in China and its special geographical position, heavy metal pollution in soils in Xihu Scenic Area has attracted great concerns. Typical heavy metals in surface soils (0- 20 cm) in Xihu Scenic Area was investigated using the grid sampling method and statistical analysis and Aregis approaches. It was suggested that there were anthropogenic accumulations of Cu, Zn and Pb in soils, and they were the main heavy metal pollutants in Xihu Scenic Area.

[Membrane fouling by secondary effluent of urban sewage and the membrane properties].

The fouling behavior of UF membranes by secondary effluent of municipal wastewater was investigated using both original PVDF membranes and PVA, PVP and PMMA modified PVDF membranes. The results showed that the structure parameters of UF membranes were optimized by blending; PVP and PVA could effectively improve the hydrophilicity and permeate flux of the membranes. The hydrophilicity and structure properties of UF membrane had stronger effect on the anti-fouling properties.

[Multicenter randomized, double-blind, placebo-controlled trial of prostaglandin E1 cream for female sexual arousal disorder].

Objective: To investigate the efficacy and safety of alprostadil cream in management of female sexual arouse disorder (FSAD), and its appropriate dose for clinical prescription.

Methods: The volunteers were assigned randomly to four groups which received alprostadil cream in different dosage (500 μg, 700 μg and 900 μg) or placebo cream, respectively. The cream was applied to the clitoris and G-spot before coitus.

[Effects of the effluent from a wastewater treatment plant in early life stage on development and growth of goldfish (Carassias auratus)].

The present study was conducted to assess the effects of effluent from a wastewater treatment plant (WWTP) on goldfish in early life stage. Fertilized eggs of the goldfish were exposed to a serial of graded concentrations of the effluent for 30 d. The hatching and survival rates of goldfish were decreased and the freaky rate was elevated with increased effluent concentrations.

[Study on developing calibration models of fatty acid composition in intact rapeseed by near infrared reflectance spectroscopy].

Four hundred ninety seven rapeseed samples, which feature multi-year, multi-loci and highly variant characteristics, were collected as a raw set. The NIR spectra were pretreated by scatter correction and mathematics treatments, and calibration models of fat acid composition of intact rapeseed were developed by using the algorithm method of modified partial least square (MPLS). Meanwhile, three types of sample cups with different capacity were used to screen the suitable calibration model for rapeseed quality breeding.