Long non-coding RNA CHRF modulates the progression of cerebral ischemia/reperfusion injury via miR-126/SOX6 signaling pathway.

Ischemic stroke remains as a major cause for disability and death in the world. Long non-coding RNA (lncRNA) cardiac hypertrophy-related factor (CHRF) has been suggested as a crucial modulator in cardiac injury and various human cancers. Nevertheless, its effects and mechanism on ischemic stroke remains unclear.