Publications by authors named "Hai-Xin Huang"
Article Synopsis
- - Seneca Valley virus (SVV) can lead to serious diseases in pregnant sows and high mortality rates in newborn piglets, causing economic losses in pig farming.
- - The 3C protease is essential for SVV's development, affecting both the virus's replication process and the host's immune response by targeting key factors that regulate these processes.
- - Recent studies focus on the 3C protease's roles in boosting viral replication, influencing cell death, and bypassing host immunity, which could guide future strategies for preventing SVV infections.
Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and intestinal pathological damage in pigs, and it has caused significant economic losses to the swine industry. Nonstructural protein 5, also called 3C-like protease, cleaves viral polypeptides and host immune-related molecules to facilitate viral replication and immune evasion. Here, we demonstrated that SADS-CoV nsp5 significantly inhibits the Sendai virus (SEV)-induced production of IFN-β and inflammatory cytokines.
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- The study evaluated toripalimab, a new PD-1 inhibitor, for treating patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) who didn't respond to standard chemotherapy.
- Among the 190 patients treated, the overall response rate (ORR) was 20.5%, with a median duration of response of 12.8 months and overall survival of 17.4 months.
- A significant correlation was found between a decrease in plasma EBV DNA after 28 days and better treatment response, while genomic alterations were linked to poorer outcomes.
[Clinical observation of sarcandra glabra combined chemoradiotherapy for treating patients with local advanced nasopharyngeal carcinoma].
Zhongguo Zhong Xi Yi Jie He Za Zhi
April 2013
Objective: To observe the short-term efficacy and radiotherapy induced acute reactions of sarcandra glabra (SG) combined chemoradiotherapy for treating patients with local advanced nasopharyngeal carcinoma.
Methods: Totally 100 nasopharyngeal carcinoma phase III - IVa patients were randomly assigned to the control group and the observation group, 50 patients in each group. All patients received chemoradiotherapy.
Objective: To study the quality changes in pre-and-post-processed pieces of Radix Polygalae.
Methods: The changes of the content of senegenin and polygalacic acid were studied.
Results: The content of polygalacic acid in post-processed piece was lower than that in pre-processed piece.
[Clinical observation on treatment of 75 mid-late stage cancer patients with yanshu Injection].
Zhongguo Zhong Xi Yi Jie He Za Zhi
August 2006
Objective: To study the effect of Yanshu Injection (YI) used in comprehensive treatment on mid-late stage cancer.
Methods: One hundred and fifty patients with malignant cancer were equally randomized into the comprehensive treatment group (group A) and the control group (group B), both groups were treated systematically according to the NCCN 2005 cancer practice guideline, but 20 ml of YI was given additionally to group A every day.
Results: After treatment, the level of plasma CD4 and CD4/CD8 ratio were significantly lower in group B than those in group A (P < 0.