Publications by authors named "Hai-Xia Bi"
BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. However, its role and mechanism in colorectal cancer (CRC) remain largely elusive. Here, we investigated the role and clinical significance of BEST4 in CRC.
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- Dihydrotestosterone (DHT) and chronic inflammation are key factors in the development of benign prostatic hyperplasia (BPH), a condition affecting prostate health.
- The study found that DHT enhances the secretion of a pro-inflammatory factor called TNF-α from M1 macrophages, which then promotes the growth of prostate stromal cells through specific cellular pathways.
- Higher levels of TNF-α were linked to larger prostate volumes in BPH patients, suggesting that targeting TNF-α might be a better treatment approach than focusing on DHT itself.