Publications by authors named "Hai-Wen Lu"

Background: Elevated Aspergillus fumigatus (A. fumigatus)-specific Immunoglobulin E (IgE) is recognized as an essential diagnostic criterion for allergic bronchopulmonary aspergillosis (ABPA). However, it remains unknown whether initial A.

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Background: The relationship between vitamin D deficiency and Pseudomonas aeruginosa (P. aeruginosa) colonization in bronchiectasis patients is not well understood.

Methods: This study was conducted at Shanghai Pulmonary Hospital from June 2014 to May 2018.

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Background: Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinical characteristics of patients with bronchiectasis in China.

Methods: The Chinese Bronchiectasis Registry (BE-China) is a prospective, observational cohort enrolling patients from 111 hospitals in China.

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Rationale: The Bronchiectasis Health Questionnaire (BHQ) is a concise, self-administered and disease-specific instrument for measuring health-related quality-of-life (HRQoL) in bronchiectasis.

Objectives: To investigate the psychometric properties of simplified Mandarin BHQ and determine the minimum clinically important difference (MCID) as a reliable clinical endpoint for assessing the efficacy of bronchiectasis treatments.

Methods: A longitudinal, randomized controlled trial cohort of 357 patients treated with tobramycin inhalation solution or saline inhalation for Pseudomonas aeruginosa infection, along with a cross-sectional observational cohort including 436 patients with bronchiectasis were analyzed.

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Background: Bronchiectasis has high rates of hemoptysis and recurrent hemoptysis, which is inconsistent among various etiologies. Idiopathic bronchiectasis and post-tuberculous bronchiectasis are two important etiologies in China, but the differences in clinical features and risk factors of recurrent hemoptysis have not been elucidated.

Methods: Patients hospitalized for idiopathic bronchiectasis or post-tuberculosis bronchiectasis were included.

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Background: Allergic bronchopulmonary aspergillosis (ABPA) is characterized by enhanced T2 inflammatory response. Fractional exhaled nitric oxide (FeNO) measurement has been used as a valuable tool in predicting the development and management of asthma, another typical T2 inflammation. However, the clinical significance of FeNO in ABPA remains unclear.

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Article Synopsis
  • * Researchers found that certain VOC levels were significantly higher in patients experiencing hypoxia and those with infections, indicating a potential link to the severity of the disease.
  • * Specifically, 10-heptadecenoic acid was identified as a key predictive marker for hypoxia, suggesting it could help assess bronchiectasis patient conditions.
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Article Synopsis
  • ABPA patients have increased levels of Th2 cells and elevated T-helper type cells linked to IgE production, with decreased Th1 and Th17 cells compared to healthy controls.
  • Flow cytometry and RNA sequencing revealed that Th2-skewed T-helper (Tph) cells significantly contribute to B-cell differentiation and IgE synthesis in ABPA patients.
  • This distinct Th2-skewed Tph cell population may serve as a potential biomarker and therapeutic target for allergic bronchopulmonary aspergillosis.
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Chronic (PA) infection significantly contributes to morbidity and mortality in bronchiectasis patients. Initiating antibiotics early may lead to the eradication of PA. Here we outline the design of a trial (ERASE; NCT06093191) assessing the efficacy and safety of inhaled tobramycin, alone or with oral ciprofloxacin, in bronchiectasis patients with a new isolation of PA.

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The relationship between symptoms, measured using a validated disease-specific questionnaire, and longitudinal exacerbation risk has not been demonstrated in bronchiectasis. The aim of this study is to investigate whether baseline symptoms, assessed using the Quality-of-Life Bronchiectasis Respiratory Symptom Scale (QoL-B-RSS) and its individual component scores, could predict future exacerbation risk in patients with bronchiectasis. The study included 436 adults with bronchiectasis from three tertiary hospitals.

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Bronchoscopic lung volume reduction (BLVR) is a feasible, safe, effective and minimally invasive technique to significantly improve the quality of life of advanced severe chronic obstructive pulmonary disease (COPD). In this study, three-dimensional computed tomography (3D-CT) automatic analysis software combined with pulmonary function test (PFT) was used to retrospectively evaluate the postoperative efficacy of BLVR patients. The purpose is to evaluate the improvement of lung function of local lung tissue after operation, maximize the benefits of patients, and facilitate BLVR in the treatment of patients with advanced COPD.

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Background: Nearly half of bronchiectasis patients receiving bronchial artery embolization (BAE) still have recurrent hemoptysis, which may be life-threatening. Worse still, the underlying risk factors of recurrence remain unknown.

Methods: A retrospective cohort was conducted of patients with idiopathic bronchiectasis who received BAE from 2015 to 2019 at eight centers.

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Background: The high-resolution computed tomography (HRCT) score is an important component of the severity and prognosis score of pulmonary alveolar proteinosis (SPSP). However, the HRCT score in SPSP only considers the extent of opacity, which is insufficient.

Methods: We retrospectively evaluated HRCT scores for 231 patients with autoimmune pulmonary alveolar proteinosis (APAP) from three centers of the China Alliance for Rare Diseases.

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Article Synopsis
  • - Bronchiectasis is a complex respiratory disease with varying prevalence across different regions, and the BE-China study aims to gather extensive data on its characteristics and progression specifically in China to compare with Western studies.
  • - This ongoing study, launched in January 2020, seeks to recruit over 10,000 patients and will collect detailed medical and lifestyle data over a span of up to 10 years, along with biological specimens for further research.
  • - Preliminary results show that by October 2021, the BE-China study had enrolled 3,758 patients and collected valuable biological samples, highlighting a strong foundation for understanding bronchiectasis in the Chinese population.
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Background: Emerging experimental and epidemiological evidence highlights a crucial cross-talk between the intestinal flora and the lungs, termed the "gut-lung axis". However, the function of the gut microbiota in bronchiectasis remains undefined. In this study, we aimed to perform a multi-omics-based approach to identify the gut microbiome and metabolic profiles in patients with bronchiectasis.

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Bamboo, being an ornamental plant, has myriad aesthetic and economic significance. Particularly, cv. Viridisulcata contains an internode color phenotype in variation in green and yellow color between the sulcus and culm, respectively.

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Background: Serum lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and CYFRA21-1 are the commonly used biomarkers to identify patients with autoimmune pulmonary alveolar proteinosis (APAP). However, it is not clear which of the biomarkers is more sensitive to the severity of the patient's condition.

Methods: APAP patients numbering 151 were enrolled in this study.

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Background: Persistent cough and large amounts of purulent sputum affects many bronchiectasis patients. No studies have evaluated the efficacy and safety of bronchoscopic airway clearance therapy and bronchoalveolar lavage (B-ACT) for non-cystic fibrosis bronchiectasis patients with acute exacerbation.

Methods: A randomised controlled trial was conducted to explore the efficacy and safety of B-ACT among 189 bronchiectasis inpatients from February 1, 2018 to February 28, 2019.

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Corticosteroid usage in acute respiratory distress syndrome (ARDS) remains controversial. We aim to explore the correlation between the different doses of corticosteroid administration and the prognosis of ARDS. All patients were diagnosed with ARDS on initial hospital admission and received systemic corticosteroid treatment for ARDS.

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The role of corticosteroids in acute lung injury (ALI) remains uncertain. This study aims to determine the underlying mechanisms of corticosteroid treatment for lipopolysaccharide (LPS)-induced inflammation and ALI. We used corticosteroid treatment for LPS-induced murine ALI model to investigate the effect of corticosteroid on ALI in vivo.

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Article Synopsis
  • The study examines the effects of total flavones of Fructus Chorspondiatis (TFFC) on preventing myocardial ischemia/reperfusion injury (MIRI) in rats using micro PET/CT imaging to track heart damage and recovery.
  • Male Sprague-Dawley rats were divided into six groups, and various tests measured myocardial injury, oxidative stress levels, and cellular changes after treatment with different doses of TFFC.
  • Results showed that TFFC significantly reduced heart cell damage and apoptosis, with high-dose treatment yielding the most improvement in heart cell morphology and function compared to lower doses.
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Background: The outbreak of COVID-19 has led to international concern. We aimed to establish an effective screening strategy in Shanghai, China, to aid early identification of patients with COVID-19.

Methods: We did a multicentre, observational cohort study in fever clinics of 25 hospitals in 16 districts of Shanghai.

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