Systematic Analysis of Autophagy-Related Signature Uncovers Prognostic Predictor for Acute Myeloid Leukemia.

Autophagy, a highly conserved cellular protein degradation process, has been involved in acute myeloid leukemia (AML). The present study aims to establish a novel, autophagy-related prognostic signature for prediction of AML prognosis. Differentially expressed autophagy-related genes in AML and healthy samples were screened using GSE1159.

Bis{6,6'-dimeth-oxy-2,2'-[ethane-1,2-diyl-bis(imino-methyl-ene)]diphenolato(1.5-)-κO,N,N',O'}terbium(III).

The title compound, [Tb(C(18)H(22.5)N(2)O(4))(2)], is isotypic with its Pr and Tb analogues. All interatomic distances, angles and the hydrogen bond geometry are very similar for the three structures.

Bis{6,6'-dimeth-oxy-2,2'-[ethane-1,2-diyl-bis(imino-methyl-ene)]diphenolato(1.5-)-κO,N,N',O'}praeseodymium(III).

The title compound, [Pr(C(18)H(22.5)N(2)O(4))(2)], is isotypic with its Er and Tb analogues. All interatomic distances, angles and the hydrogen bond geometry are very similar for the three structures.

Bis{6,6'-dimeth-oxy-2,2'-[ethane-1,2-diyl-bis(imino-methyl-ene)]diphenolato(1.5-)-κO,N,N',O'}erbium(III).

In the title compound, [Er(C(18)H(22.5)N(2)O(4))(2)], the Er atom is located on a twofold rotation axis and is eight-coordinated by four O atoms and four N atoms from two symmetry-related 6,6'-dimethoxy-2,2'-(ethane-1,2-diyldiiminodimethylene)diphenolate(1.5-) ligands.

Diaqua-bis(N,N'-dibenzyl-ethane-1,2-diamine-κN,N')nickel(II) dichloride N,N-dimethyl-formamide solvate.

The asymmetric unit of the title complex, [Ni(C(16)H(20)N(2))(2)(H(2)O)(2)]Cl(2)·C(3)H(7)NO, consists of two Ni(II) atoms, each lying on an inversion center, two Cl anions, two N,N'-dibenzyl-ethane-1,2-diamine ligands, two coordinated water mol-ecules and one N,N-dimethyl-formamide solvent mol-ecule. Each Ni(II) atom is six-coordinated in a distorted octa-hedral coordination geometry, with the equatorial plane formed by four N atoms and the axial positions occupied by two water mol-ecules. The complex mol-ecules are linked into a chain along [001] by N-H⋯Cl, N-H⋯O and O-H⋯Cl hydrogen bonds.

Di-μ-chlorido-bis-[chlorido(N,N'-dibenzyl-propane-1,2-diamine-κN,N')copper(II)].

In the title complex, [Cu(2)Cl(4)(C(17)H(22)N(2))(2)], the Cu(II) cation is coordinated by a N,N'-dibenzyl-propane-1,2-diamine ligand and two Cl(-) anions, and a Cl(-) anion from an adjacent mol-ecule further bridges to the Cu(II) cation in the apical position, with a longer Cu-Cl distance of 2.9858 (18) Å, forming a centrosymmetric dimeric complex in which each Cu(II) cation is in a distorted square-pyramidal geometry. Intra-molecular N-H⋯Cl hydrogen bonding is observed in the dimeric complex.

Poly[(N,N-dimethyl-formamide-κO)tris-(μ-naphthalene-1-acetato)terbium(III)].

In title compound, [Tb(C(12)H(9)O(2))(3)(C(3)H(7)NO)](n), the Tb atom is nine-coordinated by nine O atoms from three naphthalene-1-acetate and one N,N-dimethyl-formamide ligands. The Tb atoms are linked by three bridging naphthalene-1-acetate ligands into a chain parallel to the b axis. Further stabilization of the structure is accomplished by non-classical C-H⋯O hydrogen bonds and C-H⋯π interactions.

Tetra-kis(μ-naphthalene-1-acetato-1:2κO:O')bis-(naphthalene-1-acetato)-1κO,O';2κO,O'-bis-(1,10-phenanthroline)-1κN,N';2κN,N'-europium(III)samarium(III).

In the title compound, [EuSm(C(12)H(9)O(2))(6)(C(12)H(8)N(2))(2)], the metal site is statistically occupied (50:50) by Eu and Sm atoms, forming a centrosymmetric complex. The metal site is nine-coordinate, in a distorted monocapped square-anti-prismatic coordination geometry. Mol-ecules are linked into three chains by C-H⋯π interactions and C-H⋯O hydrogen bonds.

The dinuclear copper(II) complexes di-mu-chlorido-bis{[N,N'-bis(4-chlorobenzyl)propane-1,2-diamine]chloridocopper(II)} and di-mu-chlorido-bis{[N,N'-bis(3,4-methylenedioxybenzyl)propane-1,2-diamine]chloridocopper(II)}.

The two title dinuclear copper(II) complexes, [Cu2Cl4(C17H20Cl2N2)2], (I), and [Cu2Cl4(C19H22N2O4)2], (II), have similar coordination environments. In each complex, the asymmetric unit consists of one half-molecule and the two copper centres are bridged by a pair of Cl atoms, resulting in complexes with centrosymmetric structures containing Cu(mu-Cl)2Cu parallelogram cores; the Cu..

[N,N'-Bis(4-chloro-benz-yl)ethane-1,2-diamine]dichloridozinc(II).

In the title complex, [ZnCl(2)(C(16)H(18)Cl(2)N(2))], the asymmetric unit contains one mol-ecule and two half-mol-ecules, which have similar geometric parameters; in the latter two molecules each Zn atom lies on a twofold rotation axis. The environment about each Zn(II) atom is distorted tetra-hedral with coordination of two terminal Cl atoms and two N atoms of the N,N'-bis-(4-chloro-benz-yl)ethane-1,2-diamine ligand. Four N-H⋯Cl hydrogen bonds link the mol-ecules into a chain of R(2) (2)(8) rings in the [001] direction.