Publications by authors named "Hai-Ru Yu"
Article Synopsis
- The study investigates the roles of interferon α (IFNα) signaling and the transcription factor PITX2 in breast cancer (BCa), particularly how they may work together to contribute to endocrine resistance against treatments like letrozole.
- PITX2 expression was found to increase in BCa tissues and cells resistant to letrozole, and this increase helped protect the cancer cells from the drug's effects by enhancing the activation of the AKT signaling pathway through a protein called IFITM1.
- The findings suggest that targeting the PITX2/IFITM1 pathway may offer new therapeutic strategies to combat letrozole resistance in breast cancer patients.
Attenuation of estrogen receptor α (ERα) expression via unknown mechanism(s) is a hallmark of endocrine-resistant breast cancer (BCa) progression. Here, we report that miR-1271 was significantly down-regulated in letrozole-resistant BCa tissues and in letrozole-resistant BCa cells. miR-1271 directly targeted the chromatin of DNA damage-inducible transcript 3 (DDIT3) gene.
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