Publications by authors named "Hai-Qun Shi"
Cardiovasc Res
December 2024
Article Synopsis
- Folic acid (FA) over-supplementation during pregnancy can lead to negative outcomes for the heart health of offspring, including impaired cardiac function and increased levels of reactive oxygen species (ROS).
- In a study with pregnant mice, over-supplementation was linked to decreased left ventricular ejection fraction and other signs of cardiac dysfunction, as well as downregulation of genes vital for heart health.
- Using antioxidants like N-acetylcysteine showed potential in reversing some of the cardiac damage caused by maternal FA over-supplementation, highlighting the balance needed in FA intake during pregnancy.
