KLF16 promotes pancreatic adenocarcinoma cell proliferation and migration by positively regulating SMAD6.

Background: Pancreatic adenocarcinoma (PAAD) is a cancerous tumor with an extremely poor 5-year survival rate. The exploration of biomarkers for the diagnosis and treatment of PAAD is crucial in clinical practice. Krüppel-like factors (KLFs) are involved in a variety of biological functions in cells.

The effects of metformin on simple obesity: a meta-analysis.

Objective: To evaluate the efficacy of metformin versus a placebo in the treatment of patients with simple obesity without obesity related diseases.

Methods: A search was done on Pub-Med, EMBASE, Cochrane, and Science Citation Index Expanded databases. The main inclusion criteria included the following:(1) randomized controlled trials.