Publications by authors named "Hai-Ping Zheng"
Cyclin-dependent kinase 1 (CDK1) has a unique role in cell cycle regulation, as it is crucial for cell cycle progression and cell division. The aim of the present study was to use a combination of various detection methods to examine the expression and clinical significance of CDK1 in thyroid cancer (THCA). We used in-house tissue microarrays, immunohistochemistry, public RNA-sequencing, gene microarrays, and meta-analyses to conduct a comprehensive analysis of the role of CDK1 in the occurrence and development of THCA.
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- MicroRNAs, specifically miR-148a, were found to be significantly downregulated in osteosarcoma tissues and cell lines compared to normal tissues, which is linked to tumor progression and poor patient prognosis.
- The study identified ROCK1 as a target of miR-148a, with increased ROCK1 expression in osteosarcoma, and showed that manipulating miR-148a levels affected ROCK1 expression and the cancer cell behaviors like proliferation, migration, and invasion.
- Overall, miR-148a is proposed as a tumor suppressor that inhibits osteosarcoma growth by targeting ROCK1, highlighting its potential as a therapeutic target for treatment.
Background: Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers worldwide, and the pathogenesis is complicated at present. There iare few effective therapeutic measures, and novel therapeutic strategies are urgently required to improve clinical outcome. Ginkgo biloba extract (EGb) is reported to have an anti-cancer activity.
View Article and Find Full Text PDFObjective: To observe the changes of sperm chromatin in patients with oligo-astheno-teratozoospermia (OAT) syndrome after treated by integrated Chinese and Western medicine.
Methods: Sixty patients with OAT syndrome were treated by integrated Chinese and Western medicine for 3 months. Their sperm samples were collected before and after the treatment, subjected to acridine orange staining and analyzed by fluorescent microscopy, flow cytometry and sperm routine detection.