Publications by authors named "Hai-Miao Zhu"
Article Synopsis
- Researchers designed a new compound, 3-(benzazol-2-yl)-quinoxaline, by combining two effective structures targeting cancer, which led to the creation of thirty new derivatives.
- The most promising derivative, 12a, was found to have strong cytotoxic effects against various cancer and one normal cell line, primarily inhibiting topoisomerase I instead of directly interacting with DNA.
- Further studies showed that 12a can effectively induce cancer cell apoptosis and reduce tumor growth in models, demonstrating potential as a low-toxicity cancer treatment.
Diverse functionalized quinoxalines were synthesized in good yields from arylamines and readily available β-keto oximes through condensation and metal-free N-arylation. The reaction was compatible with various functional groups, such as halides, cyano, and esters. A mechanism was proposed based on the experimental results.
View Article and Find Full Text PDFSynthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells.
Bioorg Med Chem Lett
April 2017
2,2-Dihydroxyarylethanones, readily prepared from the commercially available aromatic ethyl ketones, were reacted with resorcinol, 3-methoxyphenol or 2-methoxyphenol in multi steps one-pot manner promoted by trifluoroacetic acid to furnish the 2,3-diarylbenzofuran derivatives in 22-95% yield. Sixteen targeted compounds were synthesized and characterized by H NMR, C NMR and HRMS. MTT assay indicated that most compounds possessed effectively inhibitory activities against the proliferation of HeLa cell.
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