Publications by authors named "Hai-Long Hu"

Article Synopsis
  • * A study involving 60 patients showed a slight decrease in left ventricular ejection fraction after treatment, yet cardiac biomarkers remained normal; however, the rate of abnormal ECGs rose significantly, particularly with fragmented QRS and prolonged QT dispersion.
  • * The findings suggest that while cardiac health indicators are mostly stable, patients need regular ECG monitoring to identify potential long-term cardiotoxic effects from their treatment.
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Puerarin is an isoflavone isolated from the medicinal plant Pueraria lobata. The purpose of this study was to study the antiinflammatory and antimatrix-degrading effects of puerarin in a rat osteoarthritis (OA) model and its protective effects on joints. The rat OA model was established by anterior cruciate ligament transection (ACLT) surgery.

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Developing new advanced nonenzymatic electrochemical nano-sensors for glucose detection has attracted intensive attraction. In this work, we designed a novel nanocomposite nonenzymatic glucose sensor by fabricating hierarchically nanostructured metal nickel on titania nanowire arrays, which was loaded on a transparent conductive substrate (i.e.

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  • * Results show that KIF5A is more highly expressed in bladder cancer tissues, correlating with worse clinical outcomes and shorter patient survival.
  • * KIF5A's knockdown led to decreased bladder cancer cell growth and movement, suggesting it is a significant player in bladder cancer progression and a potential treatment target.
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  • - Bladder cancer is a prevalent and serious cancer affecting the urinary system, with current treatments including surgery, radiation, and chemotherapy, but there's a pressing need for new therapeutic targets to improve patient outcomes.
  • - The study identified RAB38 as a protein linked to advanced bladder cancer features, such as higher stages and likelihood of recurrence, with its depletion leading to reduced cancer cell growth and movement.
  • - Overall, the findings suggest that RAB38 plays a crucial role in bladder cancer progression, making it a potential new target for treatment strategies.
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Neddylation has been researched in many different human carcinomas. However, the roles of neural precursor cell expressed, developmentally downregulated 8 (NEDD8) in bladder cancer are still unknown. Our study was the first study which systematically investigated the possible functions of NEDD8 in bladder cancer (BC) progression.

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LaAlO (LAO)/SrTiO (STO)/LaAlO (LAO) heterostructures were epitaxially deposited on TiO-terminated (100) SrTiO single-crystal substrates by laser molecular beam epitaxy. The electron Hall mobility of 1.2 × 10 cm/V s at 2 K was obtained in our trilayered heterostructures grown under 1 × 10 Torr, which was significantly higher than that in single-layer 5 unit cells LAO (∼4 × 10 cm/V s) epitaxially grown on (100) STO substrates under the same conditions.

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LaCoO epitaxial films were grown on (100), (110) and (111) oriented LaAlO substrates by the polymer-assisted deposition method. Crystal structure measurement and cross-section observation indicate that all the LaCoO films are epitaxially grown in accordance with the orientation of LaAlO substrates, with biaxial compressive strain in the plane. Owing to the different strain directions of CoO octahedron, the mean Co-O bond length increases by different amounts in (100), (110) and (111) oriented films compared with that of bulk LaCoO, and the (100) oriented LaCoO has the largest increase.

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To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD.

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The aim of the current study was to investigate the biological effect on T24 cells and human umbilical vein endothelial cells (HUVECs) of transfection with brain-specific angiogenesis inhibitor-1 (BAI-1). The recombinant plasmid pReceiver-M61-BAI-1 was transfected into human superficial bladder tumor cells (T24) and HUVECs, in parallel with the vector control. mRNA and protein expression levels of BAI‑1 were then detected by quantitative polymerase chain reaction (qPCR) and western blotting, respectively.

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Clarification of the role of magnetic ordering and scattering in two-dimensional electron gas has become increasingly important to understand the transport and magnetic behavior in the LaAlO3 (LAO)/SrTiO3 (STO) heterostructures. In this work, we report the sheet resistance of the LAO/STO heterostructures as functions of temperature, magnetic field, and field orientation. An unexpected resistance minimum was discovered at ∼10 K under a sufficiently high in-plane magnetic field.

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Objective: The objective of this article was to summarize the relationship between some components of metabolic syndrome (MetS) and the histopathologic findings in bladder cancer in a Chinese population.

Methods: We retrospectively analyzed data of 323 patients from the Department of Urology, Second Hospital of Tianjin Medical University between January 2012 and January 2014. All the patients were diagnosed with bladder cancer for the first time.

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Schwannomas are usually benign tumors that arise from well-differentiated Schwann cells. They rarely occur in the retroperitoneum. Here, we present a case of a 60-year-old man with a giant retroperitoneal pelvic mass.

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Article Synopsis
  • A 75-year-old man experienced severe urination problems, leading to a diagnosis of prostate cancer, which was later confirmed as xanthogranulomatous prostatitis after a biopsy showed distinct histopathological features.
  • The patient's treatment included medications like Tamsulosin and glucocorticoids, along with temporary catheterization, resulting in a significant decrease in PSA levels and improved urination symptoms over 20 months.
  • Xanthogranulomatous prostatitis is rare and confirmed through histopathology, and it's primarily managed with supportive care, while severe cases may require surgery like TURP, with ongoing PSA monitoring recommended.
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Objective: To compare the distribution of heme oxygenase-2 and concentration of carbon monoxide in rat penile tissue of 8, 16 and 24 months and investigate the relationship between the system of HO-2/CO and aging.

Methods: Using SABC immunohistochemistry staining, image analysis system and the method of carboxyhemoglobin standard curve, the distribution of heme oxygenase-2 and concentration of carbon monoxide in different month rat penile tissues were investigated.

Results: The penile arteries were surrounded by HO-2 positive cells, which were also seen in the trabecular meshwork of smooth muscle.

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