Publications by authors named "Hai-Lin Wu"
Purpose: The prognostic value of lymphocyte infiltration score (LIS) and its nearest neighbor distance to tumor cells (NNDTC) in giant cell tumor of bone (GCTB) is currently not well established. This study aims to characterize LIS and NNDTC and examine their correlation with denosumab treatment responsiveness, clinicopathologic features, and patient prognosis.
Methods: Using multiplexed quantitative immunofluorescence, LIS was evaluated in 253 tumor specimens, whereas NNDTC was computed using HALO software.
Background: Currently, there is limited understanding regarding the clinical significance of the tumor-stroma ratio (TSR) in giant cell tumor of bone (GCTB). Hence, we aimed to investigate the distribution of TSR in GCTB and explore its correlation with various clinicopathologic factors, immune microenvironment, survival prognosis, and denosumab treatment responsiveness.
Methods: We conducted a multicenter cohort study comprising 426 GCTB patients treated at four centers.
Background: A comprehensive understanding of the clinical characteristics and prognostic factors associated with axial chondroblastoma (ACB) is still lacking. This study aimed to understand the clinical characteristics and prognostic factors of axial chondroblastoma (ACB) and compare them with extra-axial chondroblastoma (EACB).
Methods: A retrospective review of our institution's local database was conducted, encompassing a total of 132 CB patients, of which 61 were diagnosed with ACB and 71 with EACB.
Systematic review with meta-analysis: Probiotics for treating acute diarrhoea in children with dehydration.
J Paediatr Child Health
March 2021
Article Synopsis
- * Researchers analyzed data from 17 randomized controlled trials with a total of 2,861 participants, finding that probiotics significantly shortened the duration of diarrhoea and hospital stays compared to placebo.
- * Probiotics, when used with rehydration therapy, were found to be safe and beneficial for reducing diarrhoea duration in affected children.
In high-income countries. ondansetron is an effective antiemetic in children with gastroenteritis, but data from low- and middle-income countries are sparse. This study aimed to evaluate evidences of the effectiveness of ondansetron in preventing vomiting and reducing the use of intravenous fluids in children with gastroenteritis in developing countries.
View Article and Find Full Text PDFMetal-free and controlled synthesis of sulfur-containing polymer is still a big challenge in polymer chemistry. Here, we report a metal-free, living copolymerization of carbonyl sulfide (COS) with epoxides via the cooperative catalysis of organic Lewis pairs including bases (e.g.
View Article and Find Full Text PDFArticle Synopsis
- A novel one-pot method is described for synthesizing block copolymers featuring regioregular poly(monothiocarbonate), using metal-free catalysts like Lewis bases and triethyl borane (TEB).
- The process utilizes polyethylene glycol as a chain transfer agent (CTA), resulting in block copolymers with low polydispersity and a significant increase in turnover frequency for propylene oxide.
- The incorporation of CTA also enhances control over molecular weight and effectively reduces random exchange reactions, allowing for the creation of a diverse range of sulfur-containing block copolymers.
The preparation of perfectly alternating and regioslective copolymers derived from the copolymerization of carbonyl sulfide (COS) and epoxides by metal-free Lewis pair catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (triethyl borane) is described. Colorless and highly transparent copolymers of poly(monothiocarbonate) were successfully obtained with over 99 % tail-to-head content and high molecular weight (up to 92.5 kg mol ).
View Article and Find Full Text PDFObjective: To study the serum homocysteine (Hcy) distribution and characteristics in different sex and age groups in the community residents in Wuhan, and to analyse its associated factors with multi-stepwise regression analysis.
Methods: The population under study was from three community areas in Wuhan. Demographic distribution and the correlation with other risk factors of serum Hcy were analyzed statistically.