Publications by authors named "Hai-Juan Dong"
Gastric cancer (GC) is a common malignant disease worldwide, and finding novel agents and strategies for the treatment of GC are of urgent need. Celastrol (CEL) is a well-known natural product with antineoplastic activity. In this study, pyrazole analogues were introduced at the C-29 position of CEL.
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- The study aims to create a straightforward method for extracting and fingerprinting the chemical composition of the plant Andrographis paniculata from various regions.
- High-performance liquid chromatography (HPLC) is used to develop these fingerprints, while masses are analyzed through liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS).
- Results reveal significant differences in the chemical profiles of samples from different habitats in China, suggesting that the plant's growth conditions impact its quality, leading to the classification of the samples into three distinct groups.
The bioavailability of a new spironolactone ((7alpha,17alpha)-7-(acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone, CAS 52-01-7) formulation (test) was compared with a commercially available original formulation (reference) of the drug in 20 Chinese healthy male volunteers, aged between 21 and 27. The trial was designed as an open, randomized, single blind two-sequence, two-period crossover study. Under fasting conditions, each subject received a single oral dose of 100 mg spironolactone as a test or reference formulation with a 7-day washout period between the two formulations.
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